{"id":3556,"date":"2017-08-18T00:00:00","date_gmt":"2017-08-18T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/systematic-review-of-sex-specific-reporting-of-data-cholinesterase-inhibitor-example\/"},"modified":"2023-06-14T19:20:42","modified_gmt":"2023-06-14T23:20:42","slug":"systematic-review-of-sex-specific-reporting-of-data-cholinesterase-inhibitor-example","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/systematic-review-of-sex-specific-reporting-of-data-cholinesterase-inhibitor-example\/","title":{"rendered":"Systematic review of sex-specific reporting of data: cholinesterase inhibitor example"},"content":{"rendered":"<p><strong>Objectives <\/strong>&#x2014; To improve the value of research for older adults, we examine sex-specific reporting of data from drug trials for the management of dementia. These data are important because they may influence considerations ranging from the health of populations to shared decision-making by individual patient and caregiver about the risk and benefit of a drug therapy.<\/p>\n<p><strong>Methods <\/strong>&#x2014; Randomized controlled trials of cholinesterase inhibitors (i.e., donepezil, rivastigmine, or galantamine) with clinical outcomes were identified from searches of MEDLINE, EMBASE, and the Cochrane Library. Sex-specific data were extracted from nine sections (title, abstract, introduction, methods, outcomes, results, discussion, limitations, and conclusion). Among the donepezil trials only, more detailed harms data were obtained.<\/p>\n<p><strong>Findings<\/strong> &#x2014; Thirty-three randomized controlled trials were identified evaluating 15,971 participants (9,103 (57%) female). Trials were highly cited (median citations 158, interquartile range 62-441) and published in high impact journals (median impact factor 7.4, interquartile range 3.4-8.2). Sex was not mentioned in the title, introduction, limitations, or conclusion section of any trial. Only three trials (9%) mentioned sex in the abstract (all as a demographic characteristic), and 8 (24%) in the methods. Almost all (32 (97%)) trials mentioned sex in the results as a demographic variable. One trial reported a sex difference for a secondary outcome. Among the 16 trials studying donepezil, adverse events were frequently reported and often dose-related. No trial provided sex-specific reporting of adverse events.<\/p>\n<p><strong>Conclusions <\/strong>&#x2014; There is an almost complete lack of sex-specific reporting of data in clinical trials for dementia drug therapies, and no sex-specific reporting of adverse events. Sex-specific reporting of data should be required in drug trials to increase research value and ultimately inform more tailored prescribing for older adults.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Objectives &#x2014; To improve the value of research for older adults, we examine sex-specific reporting of data from drug trials for the management of dementia. These data are important because they may influence considerations ranging from the health of populations to shared decision-making by individual patient and caregiver about the risk and benefit of a [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-3556","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Mehta N, Rodrigues C, Lamba M, Wu W, Bronskill SE, Herrmann N, Gill SS, Chan AW, Mason R, Day S, Gurwitz JH, Rochon PA. <em>J Am Geriatr Soc<\/em>. 2017; 65(10):2213-9. Epub 2017 Aug 18.","source_url":"","ices_scientist":[1159,1251,1196,1340],"site":[6735],"research_program":[6740],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"D3200642-8734-4254-AF81-0AB596AA7B5C","sitecore_item_name":"Systematic-review-of-sex-specific-reporting-of-data-cholinesterase-inhibitor-example","sitecore_field_values":"{\n  \"Title\": \"Systematic review of sex-specific reporting of data: cholinesterase inhibitor example\",\n  \"Short title\": \"Systematic review of sex-specific\",\n  \"Summary\": \"This study looked at sex-specific reporting of data from drug trials for the management of dementia. \",\n  \"Citation\": \"<p>Mehta N, Rodrigues C, Lamba M, Wu W, Bronskill SE, Herrmann N, Gill SS, Chan AW, Mason R, Day S, Gurwitz JH, Rochon PA. <em>J Am Geriatr Soc<\/em>. 2017; 65(10):2213-9. Epub 2017 Aug 18.<\/p>\",\n  \"Abstract\": \"<p><strong>Objectives <\/strong>&mdash; To improve the value of research for older adults, we examine sex-specific reporting of data from drug trials for the management of dementia. These data are important because they may influence considerations ranging from the health of populations to shared decision-making by individual patient and caregiver about the risk and benefit of a drug therapy.<\/p>n<p><strong>Methods <\/strong>&mdash; Randomized controlled trials of cholinesterase inhibitors (i.e., donepezil, rivastigmine, or galantamine) with clinical outcomes were identified from searches of MEDLINE, EMBASE, and the Cochrane Library. Sex-specific data were extracted from nine sections (title, abstract, introduction, methods, outcomes, results, discussion, limitations, and conclusion). Among the donepezil trials only, more detailed harms data were obtained.<\/p>n<p><strong>Findings<\/strong> &mdash; Thirty-three randomized controlled trials were identified evaluating 15,971 participants (9,103 (57%) female). Trials were highly cited (median citations 158, interquartile range 62-441) and published in high impact journals (median impact factor 7.4, interquartile range 3.4-8.2). Sex was not mentioned in the title, introduction, limitations, or conclusion section of any trial. Only three trials (9%) mentioned sex in the abstract (all as a demographic characteristic), and 8 (24%) in the methods. Almost all (32 (97%)) trials mentioned sex in the results as a demographic variable. One trial reported a sex difference for a secondary outcome. Among the 16 trials studying donepezil, adverse events were frequently reported and often dose-related. No trial provided sex-specific reporting of adverse events.<\/p>n<p><strong>Conclusions <\/strong>&mdash; There is an almost complete lack of sex-specific reporting of data in clinical trials for dementia drug therapies, and no sex-specific reporting of adverse events. Sex-specific reporting of data should be required in drug trials to increase research value and ultimately inform more tailored prescribing for older adults.<\/p>\",\n  \"Research Programs\": \"{46DF28D2-EDE8-4DF2-8CC0-87CEF464E435}\",\n  \"ICES Locations\": \"{FBE2D1B1-C0BA-423F-8D16-39466B6C1424}\",\n  \"ICES Scientists\": \"{68FD9EE5-974B-4CED-A597-82186232FF1D}|{5B2D929C-DA9B-45B8-8DAA-8150B2E76063}|{A8EA74FF-4975-4A0A-953D-EC1881EBD1B4}|{14B76C34-3A35-4785-86C4-9B1633E28765}\",\n  \"Posted Date\": \"20170818T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2017\/August\/Systematic-review-of-sex-specific-reporting-of-data-cholinesterase-inhibitor-example"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Systematic review of sex-specific reporting of data: cholinesterase inhibitor example<\/title>\n<meta name=\"description\" content=\"Objectives &#x2014; 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