{"id":3399,"date":"2010-01-12T00:00:00","date_gmt":"2010-01-12T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/type-2-diabetes-medication-induced-diabetes-and-monogenic-diabetes-in-canadian-children-a-prospective-national-surveillance-study\/"},"modified":"2023-06-14T19:52:34","modified_gmt":"2023-06-14T23:52:34","slug":"type-2-diabetes-medication-induced-diabetes-and-monogenic-diabetes-in-canadian-children-a-prospective-national-surveillance-study","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/type-2-diabetes-medication-induced-diabetes-and-monogenic-diabetes-in-canadian-children-a-prospective-national-surveillance-study\/","title":{"rendered":"Type 2 diabetes, medication-induced diabetes, and monogenic diabetes in Canadian children: a prospective national surveillance study"},"content":{"rendered":"<p><strong>Objective<\/strong> &#x2014; To determine in Canadian children aged &lt;18 years the 1) incidence of type 2 diabetes, medication-induced diabetes, and monogenic diabetes; 2) clinical features of type 2 diabetes; and 3) coexisting morbidity associated with type 2 diabetes at diagnosis.<\/p>\n<p><span class=\"bold\">Research Design and Methods<\/span> &#x2014; This Canadian prospective national surveillance study involved a network of pediatricians, pediatric endocrinologists, family physicians, and adult endocrinologists. Incidence rates were calculated using Canadian Census population data. Descriptive statistics were used to illustrate demographic and clinical features.<\/p>\n<p><strong>Results<\/strong> &#x2014; From a population of 7.3 million children, 345 cases of non-type 1 diabetes were reported. The observed minimum incidence rates of type 2, medication-induced, and monogenic diabetes were 1.54, 0.4, and 0.2 cases per 100,000 children aged &lt;18 years per year, respectively. On average, children with type 2 diabetes were aged 13.7 years and 8% (19 of 227) presented before 10 years. Ethnic minorities were overrepresented, but 25% (57 of 227) of children with type 2 diabetes were Caucasian. Of children with type 2 diabetes, 95% (206 of 216) were obese and 37% (43 of 115) had at least one comorbidity at diagnosis.<\/p>\n<p><strong>Conclusions<\/strong> &#x2014; This is the first prospective national surveillance study in Canada to report the incidence of type 2 diabetes in children and also the first in the world to report the incidence of medication-induced and monogenic diabetes. Rates of type 2 diabetes were higher than expected with important regional variation. These results support recommendations that screening for comorbidity should occur at diagnosis of type 2 diabetes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Objective &#x2014; To determine in Canadian children aged &lt;18 years the 1) incidence of type 2 diabetes, medication-induced diabetes, and monogenic diabetes; 2) clinical features of type 2 diabetes; and 3) coexisting morbidity associated with type 2 diabetes at diagnosis. Research Design and Methods &#x2014; This Canadian prospective national surveillance study involved a network of [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[16,50],"migration-helper-qa-sample-set":[],"class_list":["post-3399","journal_article","type-journal_article","status-publish","hentry","topic-children-and-young-people","topic-endocrinology"],"acf":{"citation":"Amed S, Dean HJ, Panagiotopoulos C, Sellers EA, Hadjiyanakis S, Laubscher TA, Dannenbaum D, Shah BR, Booth GL, Hamilton JK. <em>Diabetes Care<\/em>. 2010; 33(4):786-91. Epub 2010 Jan 12.","source_url":"http:\/\/care.diabetesjournals.org\/content\/33\/4\/786.long","ices_scientist":[1361,1175],"site":[6733],"research_program":[6746],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"B6629EDB-7420-443D-864B-9D81B77268B4","sitecore_item_name":"Type-2-diabetes-medication-induced-diabetes-and-monogenic-diabetes-in-Canadian-children","sitecore_field_values":"{\n  \"Title\": \"Type 2 diabetes, medication-induced diabetes, and monogenic diabetes in Canadian children: a prospective national surveillance study\",\n  \"Short title\": \"Type 2 diabetes, medication-induced\",\n  \"Citation\": \"<p>Amed S, Dean HJ, Panagiotopoulos C, Sellers EA, Hadjiyanakis S, Laubscher TA, Dannenbaum D, Shah BR, Booth GL, Hamilton JK. <em>Diabetes Care<\/em>. 2010; 33(4):786-91. Epub 2010 Jan 12.<\/p>\",\n  \"Abstract\": \"<p><strong>Objective<\/strong> &mdash; To determine in Canadian children aged &lt;18 years the 1) incidence of type 2 diabetes, medication-induced diabetes, and monogenic diabetes; 2) clinical features of type 2 diabetes; and 3) coexisting morbidity associated with type 2 diabetes at diagnosis.<\/p>n<p><span class=\"bold\">Research Design and Methods<\/span> &mdash; This Canadian prospective national surveillance study involved a network of pediatricians, pediatric endocrinologists, family physicians, and adult endocrinologists. Incidence rates were calculated using Canadian Census population data. Descriptive statistics were used to illustrate demographic and clinical features.<\/p>n<p><strong>Results<\/strong> &mdash; From a population of 7.3 million children, 345 cases of non-type 1 diabetes were reported. The observed minimum incidence rates of type 2, medication-induced, and monogenic diabetes were 1.54, 0.4, and 0.2 cases per 100,000 children aged &lt;18 years per year, respectively. On average, children with type 2 diabetes were aged 13.7 years and 8% (19 of 227) presented before 10 years. Ethnic minorities were overrepresented, but 25% (57 of 227) of children with type 2 diabetes were Caucasian. Of children with type 2 diabetes, 95% (206 of 216) were obese and 37% (43 of 115) had at least one comorbidity at diagnosis.<\/p>n<p><strong>Conclusions<\/strong> &mdash; This is the first prospective national surveillance study in Canada to report the incidence of type 2 diabetes in children and also the first in the world to report the incidence of medication-induced and monogenic diabetes. Rates of type 2 diabetes were higher than expected with important regional variation. These results support recommendations that screening for comorbidity should occur at diagnosis of type 2 diabetes.<\/p>n<p><a href=\"http:\/\/care.diabetesjournals.org\/content\/33\/4\/786.long\" title=\"Opens external link\">View full text<\/a><\/p>\",\n  \"Keywords\": \"{26EB1DB1-6793-4CB3-9CFB-DFF37E09FB5A}|{37AA6DB7-8D5D-46E0-BDD2-93C4B6F0035A}\",\n  \"Research Programs\": \"{CFE36C89-C969-4C23-B5E4-1BA9E5BDC273}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n  \"ICES Scientists\": \"{4CA3655C-D15C-43EC-8F5D-9FE401C24F27}|{98B8617F-C6B9-4032-9C0D-7053D3651ABA}\",\n  \"Posted Date\": \"20100112T000000\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2010\/January\/Type-2-diabetes-medication-induced-diabetes-and-monogenic-diabetes-in-Canadian-children"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Type 2 diabetes, medication-induced diabetes, and monogenic diabetes in Canadian children: a prospective national surveillance study<\/title>\n<meta name=\"description\" content=\"Objective &#x2014; 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