{"id":2917,"date":"2020-06-28T00:00:00","date_gmt":"2020-06-28T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/the-association-between-endocrine-therapy-use-and-dementia-among-post-menopausal-women-treated-for-early-stage-breast-cancer-in-ontario-canada\/"},"modified":"2023-06-14T19:38:08","modified_gmt":"2023-06-14T23:38:08","slug":"the-association-between-endocrine-therapy-use-and-dementia-among-post-menopausal-women-treated-for-early-stage-breast-cancer-in-ontario-canada","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/the-association-between-endocrine-therapy-use-and-dementia-among-post-menopausal-women-treated-for-early-stage-breast-cancer-in-ontario-canada\/","title":{"rendered":"The association between endocrine therapy use and dementia among post-menopausal women treated for early-stage breast cancer in Ontario, Canada"},"content":{"rendered":"<p><strong>Purpose <\/strong>&#x2014; The association between endocrine therapy and risk of dementia remains uncertain. We investigated the association between adjuvant endocrine therapy for breast cancer and risk of developing dementia in a real-world, population-based study.<\/p>\n<p><strong>Methods <\/strong>&#x2014; We used health administrative data collected from post-menopausal women (aged &#x2265;66 years) who were diagnosed with breast cancer and started on adjuvant endocrine therapy from 2005 to 2012 with follow-up until 2017. Patients were classified by the use of either an aromatase inhibitor or tamoxifen and followed to estimate the unadjusted cumulative incidence of developing dementia. A multivariable Cox proportional hazards model was created adjusting for age, income quintile, medical co-morbidities, and duration of endocrine therapy.<\/p>\n<p><strong>Results <\/strong>&#x2014; We identified 12,077 patients of whom 73% were treated with an aromatase inhibitor and 27% with tamoxifen. Our multivariable analysis showed a lower rate of dementia in patients treated with an aromatase inhibitor as compared to tamoxifen [Hazard ratio (HR) = 0.88, 95% confidence interval (CI): 0.78&#x2013;0.98, p-value = .02) at a median follow-up of 5.9 years. The 5-year dementia rate among patient treated with either an aromatase inhibitor or tamoxifen was 7.4% and 9.2% respectively. Older age, previous history of ischemic heart disease, diabetes, hypertension and history of stroke were all significantly associated with the development of dementia.<\/p>\n<p><strong>Conclusion <\/strong>&#x2014; Aromatase inhibitor therapy was associated with a decreased incidence of dementia as compared to treatment with tamoxifen among post-menopausal women with early stage breast cancer. Further prospective studies with longer-term follow-up investigating the neurocognitive effects of endocrine therapy are warranted.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Purpose &#x2014; The association between endocrine therapy and risk of dementia remains uncertain. We investigated the association between adjuvant endocrine therapy for breast cancer and risk of developing dementia in a real-world, population-based study. Methods &#x2014; We used health administrative data collected from post-menopausal women (aged &#x2265;66 years) who were diagnosed with breast cancer and [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-2917","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Blanchette PS, Lam M, Le B, Richard L, Shariff SZ, Pritchard KI, Raphael J, Vandenberg T, Fernandes R, Desautels D, Chan KKW, Earle CC. <em>J Geriatr Oncol<\/em>. 2020; 11(7):1132-7. Epub 2020 Jun 28.","source_url":"https:\/\/doi.org\/10.1016\/j.jgo.2020.05.009","ices_scientist":[1359,1225,1165,13132],"site":[6739],"research_program":[6741],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"9F637A0E-3CDC-4598-9D1E-5B0F6184584C","sitecore_item_name":"The-association-between-endocrine-therapy-use-and-dementia-among-post-menopausal-women-treated","sitecore_field_values":"{\n  \"Title\": \"The association between endocrine therapy use and dementia among post-menopausal women treated for early-stage breast cancer in Ontario, Canada\",\n  \"Short title\": \"The association between endocrine\",\n  \"Summary\": \"This study investigated the association between adjuvant endocrine therapy for breast cancer and risk of developing dementia in a real-world, population-based study.\",\n  \"Citation\": \"<p>Blanchette PS, Lam M, Le B, Richard L, Shariff SZ, Pritchard KI, Raphael J, Vandenberg T, Fernandes R, Desautels D, Chan KKW, Earle CC. <em>J Geriatr Oncol<\/em>. 2020; 11(7):1132-7. Epub 2020 Jun 28. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.jgo.2020.05.009\" title=\"Opens external link\">https:\/\/doi.org\/10.1016\/j.jgo.2020.05.009<\/a><\/p>\",\n  \"Abstract\": \"<p><strong>Purpose <\/strong>&mdash; The association between endocrine therapy and risk of dementia remains uncertain. We investigated the association between adjuvant endocrine therapy for breast cancer and risk of developing dementia in a real-world, population-based study.<\/p>n<p><strong>Methods <\/strong>&mdash; We used health administrative data collected from post-menopausal women (aged &ge;66 years) who were diagnosed with breast cancer and started on adjuvant endocrine therapy from 2005 to 2012 with follow-up until 2017. Patients were classified by the use of either an aromatase inhibitor or tamoxifen and followed to estimate the unadjusted cumulative incidence of developing dementia. A multivariable Cox proportional hazards model was created adjusting for age, income quintile, medical co-morbidities, and duration of endocrine therapy.<\/p>n<p><strong>Results <\/strong>&mdash; We identified 12,077 patients of whom 73% were treated with an aromatase inhibitor and 27% with tamoxifen. Our multivariable analysis showed a lower rate of dementia in patients treated with an aromatase inhibitor as compared to tamoxifen [Hazard ratio (HR) = 0.88, 95% confidence interval (CI): 0.78&ndash;0.98, p-value = .02) at a median follow-up of 5.9 years. The 5-year dementia rate among patient treated with either an aromatase inhibitor or tamoxifen was 7.4% and 9.2% respectively. Older age, previous history of ischemic heart disease, diabetes, hypertension and history of stroke were all significantly associated with the development of dementia.<\/p>n<p><strong>Conclusion <\/strong>&mdash; Aromatase inhibitor therapy was associated with a decreased incidence of dementia as compared to treatment with tamoxifen among post-menopausal women with early stage breast cancer. Further prospective studies with longer-term follow-up investigating the neurocognitive effects of endocrine therapy are warranted.<\/p>\",\n  \"Research Programs\": \"{85DE96A6-4C96-40C7-8E6D-7597A0EB5F80}\",\n  \"ICES Locations\": \"{3B4AF7E8-6835-410B-AEB8-360A79CA0ED8}\",\n  \"ICES Scientists\": \"{E8DA0CD3-1341-4EA5-846D-D3FCFCEB3137}|{B3A5A166-8F3C-43DC-8214-EFB653814F22}|{273A5750-26C4-415B-A2F3-B78E1A546CC0}|{50AE73D1-7AD4-4BCF-8129-5E0F8E219D04}\",\n  \"Posted Date\": \"20200628T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2020\/June\/The-association-between-endocrine-therapy-use-and-dementia-among-post-menopausal-women-treated"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | The association between endocrine therapy use and dementia among post-menopausal women treated for early-stage breast cancer in Ontario, Canada<\/title>\n<meta name=\"description\" content=\"Purpose &#x2014; The association between endocrine therapy and risk of dementia remains uncertain. We investigated the association between adjuvant\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/the-association-between-endocrine-therapy-use-and-dementia-among-post-menopausal-women-treated-for-early-stage-breast-cancer-in-ontario-canada\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | The association between endocrine therapy use and dementia among post-menopausal women treated for early-stage breast cancer in Ontario, Canada\" \/>\n<meta property=\"og:description\" content=\"Purpose &#x2014; The association between endocrine therapy and risk of dementia remains uncertain. 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