{"id":2883,"date":"2020-06-01T00:00:00","date_gmt":"2020-06-01T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/a-propensity-score-weighted-comparison-of-outcomes-between-living-and-standard-criteria-deceased-donor-kidney-transplant-recipients\/"},"modified":"2023-06-14T19:57:57","modified_gmt":"2023-06-14T23:57:57","slug":"a-propensity-score-weighted-comparison-of-outcomes-between-living-and-standard-criteria-deceased-donor-kidney-transplant-recipients","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/a-propensity-score-weighted-comparison-of-outcomes-between-living-and-standard-criteria-deceased-donor-kidney-transplant-recipients\/","title":{"rendered":"A propensity score-weighted comparison of outcomes between living and standard criteria deceased donor kidney transplant recipients"},"content":{"rendered":"<p><strong>Background <\/strong>&#x2014; Consider a theoretical situation in which 2 patients with similar baseline characteristics receive a kidney transplant on the same day: 1 from a standard criteria deceased donor, the other from a living donor. Which kidney transplant will last longer?<\/p>\n<p><strong>Methods<\/strong> &#x2014; We conducted a population-based cohort study using linked administrative healthcare databases from Ontario, Canada from January 1, 2005 to March 31, 2014 to evaluate several posttransplant outcomes in individuals who received a kidney transplant from a standard criteria deceased donor (n=1523) or from a living donor (n=1373). We used propensity-score weighting using overlap weights, a novel weighting method that emphasizes the population of recipients with the most overlap in baseline characteristics.<\/p>\n<p><strong>Results <\/strong>&#x2014; Compared to recipients of a living donor, the rate of all-cause graft failure was not statistically higher for recipients of a standard criteria deceased donor (hazard ratio 1.1, 95% confidence interval [CI]: 0.8, 1.6). Recipients of a standard criteria deceased donor, compared to recipients of a living donor had a higher rate of delayed graft function (23.6% vs. 18.7%, odds ratio 1.3, 95% CI: 1.0, 1.6) and a longer length of stay for the kidney transplant surgery (mean difference 1.7 days, 95% CI: 0.5, 3.0).<\/p>\n<p><strong>Conclusion <\/strong>&#x2014; After accounting for many important donor and recipient factors, we failed to observe a large difference in the risk of all-cause graft failure for recipients of a standard criteria deceased versus living donor. Some estimates were imprecise which meant we could not rule out the presence of smaller clinically important effects.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background &#x2014; Consider a theoretical situation in which 2 patients with similar baseline characteristics receive a kidney transplant on the same day: 1 from a standard criteria deceased donor, the other from a living donor. Which kidney transplant will last longer? Methods &#x2014; We conducted a population-based cohort study using linked administrative healthcare databases from [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-2883","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Yohanna S, Naylor KL, McArthur E, Lam NN, Austin PC, Habbous S, McCallum MK, Ordon M, Knoll GA, Kim JS, Garg AX. <em>Transplantation<\/em>. 2020; 104(11):e317-e27. Epub 2020 Jun 1.","source_url":"https:\/\/doi.org\/10.1097\/TP.0000000000003337","ices_scientist":[1242,1385,1308,1153,1299],"site":[6739],"research_program":[6743],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"4E6C6D5F-BF9D-4AEF-A495-B465D71D61B1","sitecore_item_name":"A-propensity-score-weighted-comparison-of-outcomes-between-living-and-standard-criteria","sitecore_field_values":"{\n  \"Title\": \"A propensity score-weighted comparison of outcomes between living and standard criteria deceased donor kidney transplant recipients\",\n  \"Short title\": \"A propensity score-weighted\",\n  \"Summary\": \"This study examined a theoretical situation in which two patients with similar baseline characteristics receive a kidney transplant on the same day.\",\n  \"Citation\": \"<p>Yohanna S, Naylor KL, McArthur E, Lam NN, Austin PC, Habbous S, McCallum MK, Ordon M, Knoll GA, Kim JS, Garg AX. <em>Transplantation<\/em>. 2020; 104(11):e317-e27. Epub 2020 Jun 1. DOI: <a href=\"https:\/\/doi.org\/10.1097\/TP.0000000000003337\" title=\"opens external link\">https:\/\/doi.org\/10.1097\/TP.0000000000003337<\/a><\/p>\",\n  \"Abstract\": \"<p><strong>Background <\/strong>&mdash; Consider a theoretical situation in which 2 patients with similar baseline characteristics receive a kidney transplant on the same day: 1 from a standard criteria deceased donor, the other from a living donor. Which kidney transplant will last longer?<\/p>n<p><strong>Methods<\/strong> &mdash; We conducted a population-based cohort study using linked administrative healthcare databases from Ontario, Canada from January 1, 2005 to March 31, 2014 to evaluate several posttransplant outcomes in individuals who received a kidney transplant from a standard criteria deceased donor (n=1523) or from a living donor (n=1373). We used propensity-score weighting using overlap weights, a novel weighting method that emphasizes the population of recipients with the most overlap in baseline characteristics.<\/p>n<p><strong>Results <\/strong>&mdash; Compared to recipients of a living donor, the rate of all-cause graft failure was not statistically higher for recipients of a standard criteria deceased donor (hazard ratio 1.1, 95% confidence interval [CI]: 0.8, 1.6). Recipients of a standard criteria deceased donor, compared to recipients of a living donor had a higher rate of delayed graft function (23.6% vs. 18.7%, odds ratio 1.3, 95% CI: 1.0, 1.6) and a longer length of stay for the kidney transplant surgery (mean difference 1.7 days, 95% CI: 0.5, 3.0).<\/p>n<p><strong>Conclusion <\/strong>&mdash; After accounting for many important donor and recipient factors, we failed to observe a large difference in the risk of all-cause graft failure for recipients of a standard criteria deceased versus living donor. Some estimates were imprecise which meant we could not rule out the presence of smaller clinically important effects.<\/p>\",\n  \"Research Programs\": \"{92CC48EB-79AA-49F6-8A80-16D185170261}\",\n  \"ICES Locations\": \"{3B4AF7E8-6835-410B-AEB8-360A79CA0ED8}\",\n  \"ICES Scientists\": \"{95F0CC45-E886-4729-A10C-DC4813D54710}|{7D498E8B-5801-4F9E-AC41-11ED50F3C34E}|{F41ECBF4-504D-4062-83A6-449CB6D234AB}|{6B4960E0-E1DA-49EB-87C0-85D66231D0E0}|{04FA589B-4B79-4CC7-B57D-0EFF84E23E86}\",\n  \"Posted Date\": \"20200601T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2020\/June\/A-propensity-score-weighted-comparison-of-outcomes-between-living-and-standard-criteria"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | A propensity score-weighted comparison of outcomes between living and standard criteria deceased donor kidney transplant recipients<\/title>\n<meta name=\"description\" content=\"Background &#x2014; 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