{"id":2570,"date":"2021-11-13T00:00:00","date_gmt":"2021-11-13T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/venous-thromboembolism-in-surgical-lung-cancer-patients-a-provincial-population-based-study\/"},"modified":"2023-11-16T11:19:53","modified_gmt":"2023-11-16T16:19:53","slug":"venous-thromboembolism-in-surgical-lung-cancer-patients-a-provincial-population-based-study","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/venous-thromboembolism-in-surgical-lung-cancer-patients-a-provincial-population-based-study\/","title":{"rendered":"Venous thromboembolism in surgical lung cancer patients: a provincial population-based study"},"content":{"rendered":"<p><strong>Background <\/strong>&#x2014; Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in surgical patients. Thoracic surgery patients are at increased risk due to inherent technical and disease-specific factors. Other surgical specialties have adopted post-discharge extended VTE prophylaxis; however, evidence is scarce in thoracic surgery. This study aims to identify VTE risk factors and associated mortality among surgical lung cancer patients.<\/p>\n<p><strong>Methods <\/strong>&#x2014; Using administrative databases, all patients in the province of Ontario undergoing lung cancer surgery from 2007 to 2017 were identified. Logistic regression identified VTE risk factors at 90-days and one-year postoperatively. A flexible parametric survival analysis compared mortality and survival up to 5 years after surgery between patients with and without VTE.<\/p>\n<p><strong>Results <\/strong>&#x2014; Of 65,513 patients diagnosed with lung cancer, 12,626 (19.3%) underwent surgery. VTE incidence at 90-days and 1-year postoperatively was 1.3% and 2.7%, respectively. Open and more extensive resections carried an increased VTE-risk, with pneumonectomy conferring the highest risk (OR = 2.36; p&lt;0.001). Stage III and IV disease carried a 3.19 and 4.97-times higher risk of VTE, respectively, compared to stage I (p&lt;0.001). The hazard ratio for mortality at one year for patients with a VTE was 2.01 (p&lt;0.001). Patients suffering a VTE had reduced 5-year survival.<\/p>\n<p><strong>Conclusions <\/strong>&#x2014; Patients undergoing pneumonectomy and those with advanced stage have an increased VTE-risk. Patients suffering a thrombotic complication have an increased risk of mortality, and decreased 5-year survival. Accordingly, strategies to reduce VTE risk should be considered in patients undergoing high risk operations to reduce the mortality of VTEs.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background &#x2014; Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in surgical patients. Thoracic surgery patients are at increased risk due to inherent technical and disease-specific factors. Other surgical specialties have adopted post-discharge extended VTE prophylaxis; however, evidence is scarce in thoracic surgery. This study aims to identify VTE risk factors and [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-2570","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Akhtar-Danesh G, Akhtar-Danesh N, Shargall Y.<em> Ann Thorac Surg<\/em>. 2022; 114(3):890-7. Epub 2021 Nov 13.","source_url":"https:\/\/doi.org\/10.1016\/j.athoracsur.2021.10.018","ices_scientist":[1380],"site":[6737],"research_program":[6741],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"BD57FB93-42A8-423A-AD9E-4DF0AFC55A34","sitecore_item_name":"Venous-thromboembolism-in-surgical-lung-cancer-patients-a-provincial-population-based-study","sitecore_field_values":"{\n  \"Title\": \"Venous thromboembolism in surgical lung cancer patients: a provincial population-based study\",\n  \"Short title\": \"Venous thromboembolism in surgical lung\",\n  \"Summary\": \"This study aims to identify venous thromboembolism risk factors and associated mortality among surgical lung cancer patients.rn\",\n  \"Citation\": \"<p>Akhtar-Danesh G, Akhtar-Danesh N, Shargall Y.<em> Ann Thorac Surg<\/em>. 2021; Nov 13 [Epub ahead of print]. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.athoracsur.2021.10.018\" title=\"Opens external link\">https:\/\/doi.org\/10.1016\/j.athoracsur.2021.10.018<\/a><\/p>\",\n  \"Abstract\": \"<p><strong>Background <\/strong>&mdash; Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in surgical patients. Thoracic surgery patients are at increased risk due to inherent technical and disease-specific factors. Other surgical specialties have adopted post-discharge extended VTE prophylaxis; however, evidence is scarce in thoracic surgery. This study aims to identify VTE risk factors and associated mortality among surgical lung cancer patients.<\/p>n<p><strong>Methods <\/strong>&mdash; Using administrative databases, all patients in the province of Ontario undergoing lung cancer surgery from 2007 to 2017 were identified. Logistic regression identified VTE risk factors at 90-days and one-year postoperatively. A flexible parametric survival analysis compared mortality and survival up to 5 years after surgery between patients with and without VTE.<\/p>n<p><strong>Results <\/strong>&mdash; Of 65,513 patients diagnosed with lung cancer, 12,626 (19.3%) underwent surgery. VTE incidence at 90-days and 1-year postoperatively was 1.3% and 2.7%, respectively. Open and more extensive resections carried an increased VTE-risk, with pneumonectomy conferring the highest risk (OR = 2.36; p&lt;0.001). Stage III and IV disease carried a 3.19 and 4.97-times higher risk of VTE, respectively, compared to stage I (p&lt;0.001). The hazard ratio for mortality at one year for patients with a VTE was 2.01 (p&lt;0.001). Patients suffering a VTE had reduced 5-year survival.<\/p>n<p><strong>Conclusions <\/strong>&mdash; Patients undergoing pneumonectomy and those with advanced stage have an increased VTE-risk. Patients suffering a thrombotic complication have an increased risk of mortality, and decreased 5-year survival. Accordingly, strategies to reduce VTE risk should be considered in patients undergoing high risk operations to reduce the mortality of VTEs.<\/p>\",\n  \"Research Programs\": \"{85DE96A6-4C96-40C7-8E6D-7597A0EB5F80}\",\n  \"ICES Locations\": \"{D88BC40D-6453-47B1-9A95-3AC57728064D}\",\n  \"ICES Scientists\": \"{2AA65EAF-4290-4BCF-A509-ECAAA9CC1493}\",\n  \"Posted Date\": \"20211113T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2021\/November\/Venous-thromboembolism-in-surgical-lung-cancer-patients-a-provincial-population-based-study"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Venous thromboembolism in surgical lung cancer patients: a provincial population-based study<\/title>\n<meta name=\"description\" content=\"Background &#x2014; Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in surgical patients. 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