{"id":2496,"date":"2021-05-26T00:00:00","date_gmt":"2021-05-26T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/long-term-kidney-outcomes-following-childhood-acute-kidney-injury-receiving-dialysis-a-population-based-cohort-study\/"},"modified":"2023-06-14T20:11:46","modified_gmt":"2023-06-15T00:11:46","slug":"long-term-kidney-outcomes-following-childhood-acute-kidney-injury-receiving-dialysis-a-population-based-cohort-study","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/long-term-kidney-outcomes-following-childhood-acute-kidney-injury-receiving-dialysis-a-population-based-cohort-study\/","title":{"rendered":"Long-term kidney outcomes following childhood acute kidney injury receiving dialysis: a population-based cohort study"},"content":{"rendered":"<p><strong>Background <\/strong>&#x2014; Acute kidney injury (AKI) is common during pediatric hospitalizations and associated with adverse short-term outcomes. However, long-term outcomes among survivors of pediatric AKI who received dialysis remain uncertain.<\/p>\n<p><strong>Methods <\/strong>&#x2014; To determine the long-term risk of kidney failure (defined as receipt of chronic dialysis or kidney transplant) or death over a 22-year period for pediatric survivors of dialysistreated AKI, we used province-wide health administrative databases to perform a retrospective cohort study of all neonates and children (aged 0-18 years) hospitalized in Ontario, Canada, from April 1, 1996, to March 31, 2017, who survived a dialysis-treated AKI episode. Each AKI survivor was matched to four hospitalized pediatric comparators without dialysis-treated AKI, based on age, sex, and admission year. We reported the incidence of each outcome and performed Cox proportional hazards regression analyses, adjusting for relevant covariates.<\/p>\n<p><strong>Results <\/strong>&#x2014; We identified 1688 pediatric dialysis-treated AKI survivors (median age 5 years) and 6752 matched comparators. Among AKI survivors, 53.7% underwent mechanical ventilation and 33.6% had cardiac surgery. During a median 9.6-year follow-up, AKI survivors were at significantly increased risk of a  composite outcome of kidney failure or death versus comparators. Death occurred in 113 (6.7%) AKI survivors, 44 (2.6%) developed kidney failure, 174 (12.1%) developed hypertension, 213 (13.1%) developed chronic kidney disease (CKD), and 237 (14.0%) had subsequent AKI. AKI survivors had significantly higher risks of developing CKD and hypertension versus comparators. Risks were greatest in the first year after discharge and gradually decreased over time.<\/p>\n<p><strong>Conclusions <\/strong>&#x2014; Survivors of pediatric dialysis-treated AKI are at higher long-term risks of kidney failure, death, CKD, and hypertension, compared with a matched hospitalized cohort.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background &#x2014; Acute kidney injury (AKI) is common during pediatric hospitalizations and associated with adverse short-term outcomes. However, long-term outcomes among survivors of pediatric AKI who received dialysis remain uncertain. Methods &#x2014; To determine the long-term risk of kidney failure (defined as receipt of chronic dialysis or kidney transplant) or death over a 22-year period [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-2496","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Robinson C, Jeyakumar N, Luo B, Wald R, Garg A, Nash D, McArthur E, Greenberg J, Askenazi D, Mammen C, Thabane L, Goldstein S, Parekh R, Zappitelli M, Chanchlani R. <em>J Am Soc Nephrol<\/em>. 2021; 32(8):2005-19. Epub 2021 May 26.","source_url":"https:\/\/doi.org\/10.1681\/ASN.2020111665","ices_scientist":[1242,1123,1194],"site":[6739],"research_program":[6743],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"6049C874-4627-4249-AA98-F3B1782A18AC","sitecore_item_name":"Long-term-kidney-outcomes-following-childhood-acute-kidney-injury-receiving-dialysis","sitecore_field_values":"{\n  \"Title\": \"Long-term kidney outcomes following childhood acute kidney injury receiving dialysis: a population-based cohort study\",\n  \"Short title\": \"Long-term kidney outcomes following\",\n  \"Summary\": \"Acute kidney injury is common during pediatric hospitalizations and associated with adverse short-term outcomes. Long-term outcomes among survivors of pediatric AKI remain uncertain.\",\n  \"Citation\": \"<p>Robinson C, Jeyakumar N, Luo B, Wald R, Garg A, Nash D, McArthur E, Greenberg J, Askenazi D, Mammen C, Thabane L, Goldstein S, Parekh R, Zappitelli M, Chanchlani R. <em>J Am Soc Nephrol<\/em>. 2021; 32(8):2005-19. Epub 2021 May 26. DOI: <a href=\"https:\/\/doi.org\/10.1681\/ASN.2020111665\" title=\"opens external link\">https:\/\/doi.org\/10.1681\/ASN.2020111665<\/a><\/p>\",\n  \"Abstract\": \"<p><strong>Background <\/strong>&mdash; Acute kidney injury (AKI) is common during pediatric hospitalizations and associated with adverse short-term outcomes. However, long-term outcomes among survivors of pediatric AKI who received dialysis remain uncertain.<\/p>n<p><strong>Methods <\/strong>&mdash; To determine the long-term risk of kidney failure (defined as receipt of chronic dialysis or kidney transplant) or death over a 22-year period for pediatric survivors of dialysistreated AKI, we used province-wide health administrative databases to perform a retrospective cohort study of all neonates and children (aged 0-18 years) hospitalized in Ontario, Canada, from April 1, 1996, to March 31, 2017, who survived a dialysis-treated AKI episode. Each AKI survivor was matched to four hospitalized pediatric comparators without dialysis-treated AKI, based on age, sex, and admission year. We reported the incidence of each outcome and performed Cox proportional hazards regression analyses, adjusting for relevant covariates.<\/p>n<p><strong>Results <\/strong>&mdash; We identified 1688 pediatric dialysis-treated AKI survivors (median age 5 years) and 6752 matched comparators. Among AKI survivors, 53.7% underwent mechanical ventilation and 33.6% had cardiac surgery. During a median 9.6-year follow-up, AKI survivors were at significantly increased risk of a \\ composite outcome of kidney failure or death versus comparators. Death occurred in 113 (6.7%) AKI survivors, 44 (2.6%) developed kidney failure, 174 (12.1%) developed hypertension, 213 (13.1%) developed chronic kidney disease (CKD), and 237 (14.0%) had subsequent AKI. AKI survivors had significantly higher risks of developing CKD and hypertension versus comparators. Risks were greatest in the first year after discharge and gradually decreased over time.<\/p>n<p><strong>Conclusions <\/strong>&mdash; Survivors of pediatric dialysis-treated AKI are at higher long-term risks of kidney failure, death, CKD, and hypertension, compared with a matched hospitalized cohort.<\/p>\",\n  \"Research Programs\": \"{92CC48EB-79AA-49F6-8A80-16D185170261}\",\n  \"ICES Locations\": \"{3B4AF7E8-6835-410B-AEB8-360A79CA0ED8}\",\n  \"ICES Scientists\": \"{95F0CC45-E886-4729-A10C-DC4813D54710}|{09D1444D-60AE-4886-8599-18E41E418EBB}|{EC1DE6BC-A11C-4D70-831A-B29CE8673088}\",\n  \"Posted Date\": \"20210526T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2021\/May\/Long-term-kidney-outcomes-following-childhood-acute-kidney-injury-receiving-dialysis"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Long-term kidney outcomes following childhood acute kidney injury receiving dialysis: a population-based cohort study<\/title>\n<meta name=\"description\" content=\"Background &#x2014; Acute kidney injury (AKI) is common during pediatric hospitalizations and associated with adverse short-term outcomes. 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