{"id":24679,"date":"2026-10-28T13:30:12","date_gmt":"2026-10-28T17:30:12","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=24679"},"modified":"2026-10-30T16:24:20","modified_gmt":"2026-10-30T20:24:20","slug":"incidence-of-dementia-and-subsequent-outcomes-in-patients-with-heart-failure","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/incidence-of-dementia-and-subsequent-outcomes-in-patients-with-heart-failure\/","title":{"rendered":"Incidence of dementia and subsequent outcomes in patients with heart failure"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 Dementia and heart failure (HF) frequently coexist; however, the relationship between these conditions is not fully explored.<\/p>\n<p><strong>Objectives<\/strong> \u2014 The objectives of the study were to: 1) compare dementia incidence in newly-diagnosed patients with HF or matched non-HF controls; and 2) examine risk factors for and outcomes after dementia diagnosis in HF patients.<\/p>\n<p><strong>Methods<\/strong> \u2014 In community-dwelling residents (aged 40-80 years), we compared incident dementia in those with new-onset HF vs age\/sex, and cardiovascular risk factor\/disease-matched non-HF controls. In those with HF, we examined time-varying dementia onset as the exposure with outcomes of mortality and hospitalization. We also compared physician visits after vs before dementia diagnosis.<\/p>\n<p><strong>Results<\/strong> \u2014 Among 211,548 outpatients with HF (median 68 [60-75] years, 41.2% female), time-dependent HRs for dementia were 1.42 (95% CI: 1.38-1.47) at 5 years and 1.31 (95% CI: 1.27-1.35) at 10 years compared to non-HF controls. Prior stroke or transient ischemia attack (HR: 1.41; 95% CI: 1.33-1.50) and hospital frailty risk score &gt;10 vs &lt;5 (HR: 1.93; 95% CI: 1.77-2.09) were important predictors of dementia (both P &lt; 0.001). Incident dementia was associated with higher multivariable-adjusted hazards of all-cause mortality (HR: 2.44; 95% CI: 2.40-2.49) and all-cause hospitalization (HR: 1.63; 95% CI: 1.58-1.69) in outpatients with HF (all P &lt; 0.001). Rates of outpatient physician visits with primary care, internal medicine, cardiologists (post\/pre-rate ratio range 1.08-1.19), and geriatricians (post\/prerate ratio 10.70; all P &lt; 0.001) were higher after (versus before) dementia onset.<\/p>\n<p><strong>Conclusions<\/strong> \u2014 Incident HF was associated with higher risk of incident dementia. Dementia onset was associated with higher rates of outpatient physician visits and increased risk of adverse outcomes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 Dementia and heart failure (HF) frequently coexist; however, the relationship between these conditions is not fully explored. Objectives \u2014 The objectives of the study were to: 1) compare dementia incidence in newly-diagnosed patients with HF or matched non-HF controls; and 2) examine risk factors for and outcomes after dementia diagnosis in HF patients. [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[41,40],"migration-helper-qa-sample-set":[],"class_list":["post-24679","journal_article","type-journal_article","status-publish","hentry","topic-brain-diseases","topic-cardiovascular-disease"],"acf":{"citation":"Tieu P, Joundi RA, McAlister FA, Kapral MK, Khan N, Swartz RH, Atzema CL, Austin PC, Barber PA, Billia F, Bolz SS, Connelly KA, Cox JL, Demers C, Duchesne S, Field TS, Fish JE, Floras JS, Franklin D, Ha ACT, Hanneman K, Odugbemi T, Quinn KL, Rudzicz F, Simard A, Singnurkar A, Smith EE, Straus SE, Styra R, Sun LY, Taljaard M, Varickanickal J, Verma A, Wang X, Yan AT, Zieroth S, Hill MD, Ross HJ, Saposnik G, Lee DS; UNEARTH CVD Investigators. <em>JACC Adv<\/em>. 2026; 5(10 Pt 2): 103248.","source_url":"https:\/\/doi.org\/10.1016\/j.jacadv.2026.103248","ices_scientist":[13135,1150,1354,1383,1385,1104,1350,21862,1365,1290],"site":[6733],"research_program":[6742],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Incidence of dementia and subsequent outcomes in patients with heart failure<\/title>\n<meta name=\"description\" content=\"Background \u2014 Dementia and heart failure (HF) frequently coexist; however, the relationship between these conditions is not fully explored. Objectives \u2014\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/incidence-of-dementia-and-subsequent-outcomes-in-patients-with-heart-failure\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Incidence of dementia and subsequent outcomes in patients with heart failure\" \/>\n<meta property=\"og:description\" content=\"Background \u2014 Dementia and heart failure (HF) frequently coexist; however, the relationship between these conditions is not fully explored. 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