{"id":24633,"date":"2026-10-12T14:17:48","date_gmt":"2026-10-12T18:17:48","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=24633"},"modified":"2026-10-15T14:23:27","modified_gmt":"2026-10-15T18:23:27","slug":"positive-airway-pressure-initiation-and-pulmonary-outcomes-in-persons-with-cystic-fibrosis","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/positive-airway-pressure-initiation-and-pulmonary-outcomes-in-persons-with-cystic-fibrosis\/","title":{"rendered":"Positive airway pressure initiation and pulmonary outcomes in persons with cystic fibrosis"},"content":{"rendered":"<p><strong>Introduction<\/strong> \u2014 It is uncertain if treating sleep breathing disorders in the setting of cystic fibrosis (CF) improves pulmonary outcomes.<\/p>\n<p><strong>Objective<\/strong> \u2014 Among persons with CF, our purpose was to evaluate the relationship between incident positive airway pressure (PAP) receipt and respiratory-related hospitalisations and lung function trajectory.<\/p>\n<p><strong>Methods<\/strong> \u2014 This retrospective, data-linkage, population-based, self-controlled interval risk study linked data from the Canadian CF Registry and Ontario health administrative databases. All persons with CF newly receiving PAP between 1 January 2009 and 31 December 2020, who remained alive and did not receive lung transplantation during follow-up, were included. Rate of respiratory-related hospitalisations and the rate of change in %predicted forced expiratory volume in 1 s (FEV1) were evaluated in the 6 months before versus 6 months after PAP receipt. We separately evaluated our outcomes among incident continuous PAP (CPAP) recipients and incident bilevel PAP (BPAP) recipients.<\/p>\n<p><strong>Results<\/strong> \u2014 We identified 28 incident CPAP recipients and 44 incident BPAP recipients. In adjusted analyses, non-significant reduced rates of respiratory-related hospitalisations were observed post-PAP versus pre-PAP for both PAP groups (CPAP: rate ratio (RR) 0.97, 95% CI 0.56 to 1.69; BPAP: RR 0.76, 95% CI 0.53 to 1.08). In adjusted analyses, rate of change in %predicted FEV1 was significantly improved post-PAP versus pre-PAP for BPAP recipients (+3.2\u2009vs \u221212.9 %predicted\/year, p&lt;0.0001), but not for CPAP recipients (+2.4\u2009vs +0.2 %predicted\/year, p=0.45).<\/p>\n<p><strong>Conclusions<\/strong> \u2014 Among persons with CF newly receiving BPAP (but not CPAP), a significant improvement in lung function trajectory post-PAP receipt was observed, accompanied by non-significant trends towards lower rates of respiratory-related hospitalisations.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Introduction \u2014 It is uncertain if treating sleep breathing disorders in the setting of cystic fibrosis (CF) improves pulmonary outcomes. Objective \u2014 Among persons with CF, our purpose was to evaluate the relationship between incident positive airway pressure (PAP) receipt and respiratory-related hospitalisations and lung function trajectory. Methods \u2014 This retrospective, data-linkage, population-based, self-controlled interval [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[42,52],"migration-helper-qa-sample-set":[],"class_list":["post-24633","journal_article","type-journal_article","status-publish","hentry","topic-chronic-diseases-and-multimorbidity","topic-lung-health"],"acf":{"citation":"Vozoris NT, Sharpe I, Sykes J, Ryan CM, Tullis E, Stephenson AL. <em>BMJ Open Respir Res<\/em>. 2026; 13(1): e004456.","source_url":"https:\/\/doi.org\/10.1136\/bmjresp-2026-004456","ices_scientist":[1115],"site":[6733],"research_program":[6746],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Positive airway pressure initiation and pulmonary outcomes in persons with cystic fibrosis<\/title>\n<meta name=\"description\" content=\"Introduction \u2014 It is uncertain if treating sleep breathing disorders in the setting of cystic fibrosis (CF) improves pulmonary outcomes. Objective \u2014 Among\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/positive-airway-pressure-initiation-and-pulmonary-outcomes-in-persons-with-cystic-fibrosis\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Positive airway pressure initiation and pulmonary outcomes in persons with cystic fibrosis\" \/>\n<meta property=\"og:description\" content=\"Introduction \u2014 It is uncertain if treating sleep breathing disorders in the setting of cystic fibrosis (CF) improves pulmonary outcomes. 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