{"id":24411,"date":"2026-08-14T15:44:39","date_gmt":"2026-08-14T19:44:39","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=24411"},"modified":"2026-08-19T15:47:57","modified_gmt":"2026-08-19T19:47:57","slug":"lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\/","title":{"rendered":"Lung transplantation in rheumatoid arthritis related interstitial lung disease: risk factors and mortality in a universal health care system"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 Despite therapy, some patients with rheumatoid arthritis related interstitial lung disease (RA-ILD) require lung transplantation for progressive disease. We aimed to identify factors associated with lung transplantation and post-transplantation survival in RA-ILD.<\/p>\n<p><strong>Methods<\/strong> \u2014 We performed a retrospective observational cohort study using data from Ontario, Canada between 2003 and 2022. RA-ILD patients were identified from the Ontario RA Database. We used a cause-specific hazards model, considering the competing risk of death, to identify factors associated with lung transplantation. A Cox proportional hazards model was used to evaluate post-transplant survival.<\/p>\n<p><strong>Results<\/strong> \u2014 Among 6470 RA-ILD patients, 77 (1.2%) underwent lung transplantation, equating to 2.40 transplants per 1000 person years. The median time to transplant was 3.7 years. Younger age [HR 0.93 per increasing year (95%CI 0.91\u20130.95), p &lt; 0.0001], male sex [HR 2.40 (95%CI 1.523.78), p = 0.0002], and comorbid diabetes [HR 1.70 (95%CI 1.06\u20132.73), p = 0.003], congestive heart failure [HR 1.87 (95%CI 1.15\u20133.04), p = 0.01] and COPD [HR 2.14 (95%CI 1.25\u20133.68), p = 0.006] were associated with transplantation. The median survival following transplantation was 4.3 years.<\/p>\n<p><strong>Conclusion<\/strong> \u2014 Lung transplantation is an uncommon, but important therapy for RA-ILD. Select comorbidities are associated with lung transplantation. Post-transplant survival among RA-ILD patients in Ontario was comparable to that reported elsewhere.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 Despite therapy, some patients with rheumatoid arthritis related interstitial lung disease (RA-ILD) require lung transplantation for progressive disease. We aimed to identify factors associated with lung transplantation and post-transplantation survival in RA-ILD. Methods \u2014 We performed a retrospective observational cohort study using data from Ontario, Canada between 2003 and 2022. RA-ILD patients were [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[52,51,54],"migration-helper-qa-sample-set":[],"class_list":["post-24411","journal_article","type-journal_article","status-publish","hentry","topic-lung-health","topic-musculoskeletal-diseases-and-disorders","topic-organ-transplantation-and-donation"],"acf":{"citation":"Fidler LM, Arbiv OA, Munn JS, Fisher JH, Shapera S, Austin PC, Gershon AS. <em>Clin Transplant<\/em>. 2026; 40(8): e70644.","source_url":"https:\/\/doi.org\/10.1111\/ctr.70644","ices_scientist":[20911,1385,1244],"site":[6735],"research_program":[6746],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Lung transplantation in rheumatoid arthritis related interstitial lung disease: risk factors and mortality in a universal health care system<\/title>\n<meta name=\"description\" content=\"Background \u2014 Despite therapy, some patients with rheumatoid arthritis related interstitial lung disease (RA-ILD) require lung transplantation for\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Lung transplantation in rheumatoid arthritis related interstitial lung disease: risk factors and mortality in a universal health care system\" \/>\n<meta property=\"og:description\" content=\"Background \u2014 Despite therapy, some patients with rheumatoid arthritis related interstitial lung disease (RA-ILD) require lung transplantation for\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\/\" \/>\n<meta property=\"og:site_name\" content=\"ICES\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ICESOntario\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-08-19T19:47:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\\\/\",\"name\":\"ICES | Lung transplantation in rheumatoid arthritis related interstitial lung disease: risk factors and mortality in a universal health care system\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\"},\"datePublished\":\"2026-08-14T19:44:39+00:00\",\"dateModified\":\"2026-08-19T19:47:57+00:00\",\"description\":\"Background \u2014 Despite therapy, some patients with rheumatoid arthritis related interstitial lung disease (RA-ILD) require lung transplantation for\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Journal Articles\",\"item\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Lung transplantation in rheumatoid arthritis related interstitial lung disease: risk factors and mortality in a universal health care system\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\",\"name\":\"ICES\",\"description\":\"POPULATION-BASED HEALTH RESEARCH THAT MAKES A DIFFERENCE\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#organization\"},\"alternateName\":\"Institute for Clinical Evaluative Sciences\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#organization\",\"name\":\"ICES\",\"alternateName\":\"Institute for Clinical Evaluative Sciences\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/ices-logo.png\",\"contentUrl\":\"https:\\\/\\\/www.ices.on.ca\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/ices-logo.png\",\"width\":\"676\",\"height\":\"618\",\"caption\":\"ICES\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/ICESOntario\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/ices-research-institute\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"ICES | Lung transplantation in rheumatoid arthritis related interstitial lung disease: risk factors and mortality in a universal health care system","description":"Background \u2014 Despite therapy, some patients with rheumatoid arthritis related interstitial lung disease (RA-ILD) require lung transplantation for","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\/","og_locale":"fr_FR","og_type":"article","og_title":"ICES | Lung transplantation in rheumatoid arthritis related interstitial lung disease: risk factors and mortality in a universal health care system","og_description":"Background \u2014 Despite therapy, some patients with rheumatoid arthritis related interstitial lung disease (RA-ILD) require lung transplantation for","og_url":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\/","og_site_name":"ICES","article_publisher":"https:\/\/www.facebook.com\/ICESOntario\/","article_modified_time":"2026-08-19T19:47:57+00:00","og_image":[{"width":1200,"height":675,"url":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\/","url":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\/","name":"ICES | Lung transplantation in rheumatoid arthritis related interstitial lung disease: risk factors and mortality in a universal health care system","isPartOf":{"@id":"https:\/\/www.ices.on.ca\/fr\/#website"},"datePublished":"2026-08-14T19:44:39+00:00","dateModified":"2026-08-19T19:47:57+00:00","description":"Background \u2014 Despite therapy, some patients with rheumatoid arthritis related interstitial lung disease (RA-ILD) require lung transplantation for","breadcrumb":{"@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/lung-transplantation-in-rheumatoid-arthritis-related-interstitial-lung-disease-risk-factors-and-mortality-in-a-universal-health-care-system\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.ices.on.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"Journal Articles","item":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/"},{"@type":"ListItem","position":3,"name":"Lung transplantation in rheumatoid arthritis related interstitial lung disease: risk factors and mortality in a universal health care system"}]},{"@type":"WebSite","@id":"https:\/\/www.ices.on.ca\/fr\/#website","url":"https:\/\/www.ices.on.ca\/fr\/","name":"ICES","description":"POPULATION-BASED HEALTH RESEARCH THAT MAKES A DIFFERENCE","publisher":{"@id":"https:\/\/www.ices.on.ca\/fr\/#organization"},"alternateName":"Institute for Clinical Evaluative Sciences","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.ices.on.ca\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/www.ices.on.ca\/fr\/#organization","name":"ICES","alternateName":"Institute for Clinical Evaluative Sciences","url":"https:\/\/www.ices.on.ca\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.ices.on.ca\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/04\/ices-logo.png","contentUrl":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/04\/ices-logo.png","width":"676","height":"618","caption":"ICES"},"image":{"@id":"https:\/\/www.ices.on.ca\/fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/ICESOntario\/","https:\/\/www.linkedin.com\/company\/ices-research-institute\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/journal_article\/24411","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/journal_article"}],"about":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/types\/journal_article"}],"acf:post":[{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/research_program\/6746"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/site\/6735"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1244"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1385"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/20911"}],"wp:attachment":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/media?parent=24411"}],"wp:term":[{"taxonomy":"migration-helper-automated","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-helper-automated?post=24411"},{"taxonomy":"migration-manual","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-manual?post=24411"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/topic?post=24411"},{"taxonomy":"migration-helper-qa-sample-set","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-helper-qa-sample-set?post=24411"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}