{"id":24377,"date":"2026-08-04T21:49:51","date_gmt":"2026-08-05T01:49:51","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=24377"},"modified":"2026-08-10T21:54:56","modified_gmt":"2026-08-11T01:54:56","slug":"comorbidity-patterns-among-pregnant-individuals-with-a-history-of-seeking-health-care-for-migraine","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/comorbidity-patterns-among-pregnant-individuals-with-a-history-of-seeking-health-care-for-migraine\/","title":{"rendered":"Comorbidity patterns among pregnant individuals with a history of seeking health care for migraine: a population-based latent class analysis in Ontario, Canada"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 Comorbidity is common with migraine. To inform services to support maternal well-being, we identified comorbidity patterns among pregnant individuals with a history of seeking health care for migraine before pregnancy.<\/p>\n<p><strong>Methods<\/strong> \u2014 In a population-based cohort of pregnancies in 2007\u20132022 in Ontario, Canada, to individuals with migraine-related health care encounters in the 5 years before conception, we used latent class analysis to identify subgroups using 33 comorbidities. Classes were chosen using statistical fit indices, parsimony, and clinical interpretability. We compared the sociodemographic and reproductive health-related characteristics of the classes using standardized differences.<\/p>\n<p><strong>Results<\/strong> \u2014 Of 174,164 pregnant individuals with migraine, 67.2% had one or more comorbidities. The most prevalent comorbidities were mood\/anxiety disorders (41.4%), low back pain (16.9%), obesity (12.1%), and asthma (10.6%). Three distinct subgroups characterized comorbidity patterns: class 1, the \u201cmood\/anxiety disorder comorbidity,\u201d included 81.2% of the cohort; class 2, the \u201cmood\/anxiety disorder and low back pain comorbidity\u201d cohort included 8.3%\u2019 and class 3, the \u201cmultiple mental health comorbidity\u201d cohort included 10.6%. Compared with class 1, at conception individuals in the \u201cmultiple mental health comorbidity\u201d group were more likely to be aged 13 to 24 years (37.9% vs. 18.9%; standardized difference, 0.43), reside in neighborhoods in the lowest income quintile (29.7% vs. 22.1%, 0.17), be Canadian born or a long-term resident (87.0% vs. 74.4%, 0.32), and be nulliparous (53.2% vs. 47.5%, 0.11). Those in the \u201cmood\/anxiety disorder and low back pain comorbidity\u201d group were more likely to be 35 to 44 years of age (31.9% vs. 20.6%, 0.26) or 45 to 54 years of age (2.1% vs. 0.6%, 0.14), more likely to reside in neighborhoods in the lowest income quintile (26.6% vs. 22.1%, 0.11), and less likely to be nulliparous (38.6% vs. 47.5%, 0.18). Findings were similar in a sensitivity analysis including only comorbidities with a prevalence of 1% or greater. Using physical conditions as indicators only, we also identified three latent classes: \u201clow back pain comorbidity\u201d (4.3%), \u201cobesity comorbidity\u201d (2.8%), and \u201cno physical comorbidity\u201d (92.9%).<\/p>\n<p><strong>Conclusion<\/strong> \u2014 Comorbidity affects two-thirds of pregnant individuals with a history of seeking health care for migraine. Identified patterns of comorbidity suggest subgroups who may benefit from tailored perinatal support related to mental health and chronic pain.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 Comorbidity is common with migraine. To inform services to support maternal well-being, we identified comorbidity patterns among pregnant individuals with a history of seeking health care for migraine before pregnancy. Methods \u2014 In a population-based cohort of pregnancies in 2007\u20132022 in Ontario, Canada, to individuals with migraine-related health care encounters in the 5 [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[41,62,26],"migration-helper-qa-sample-set":[],"class_list":["post-24377","journal_article","type-journal_article","status-publish","hentry","topic-brain-diseases","topic-health-services-research","topic-maternity-and-neonatal-care"],"acf":{"citation":"Albanese CM, Bondy SJ, Lay C, Vyas MV, Li Z, Guan J, Brown HK. <em>Womens Health Issues<\/em>. 2026; S1049-3867(26): 00103-9. Epub 2026 Aug 4.","source_url":"https:\/\/doi.org\/10.1016\/j.whi.2026.06.008","ices_scientist":[1179,1118,1164],"site":[6733],"research_program":[6740],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Comorbidity patterns among pregnant individuals with a history of seeking health care for migraine: a population-based latent class analysis in Ontario, Canada<\/title>\n<meta name=\"description\" content=\"Background \u2014 Comorbidity is common with migraine. To inform services to support maternal well-being, we identified comorbidity patterns among pregnant\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/comorbidity-patterns-among-pregnant-individuals-with-a-history-of-seeking-health-care-for-migraine\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Comorbidity patterns among pregnant individuals with a history of seeking health care for migraine: a population-based latent class analysis in Ontario, Canada\" \/>\n<meta property=\"og:description\" content=\"Background \u2014 Comorbidity is common with migraine. To inform services to support maternal well-being, we identified comorbidity patterns among pregnant\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/comorbidity-patterns-among-pregnant-individuals-with-a-history-of-seeking-health-care-for-migraine\/\" \/>\n<meta property=\"og:site_name\" content=\"ICES\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ICESOntario\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-08-11T01:54:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/comorbidity-patterns-among-pregnant-individuals-with-a-history-of-seeking-health-care-for-migraine\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/comorbidity-patterns-among-pregnant-individuals-with-a-history-of-seeking-health-care-for-migraine\\\/\",\"name\":\"ICES | Comorbidity patterns among pregnant individuals with a history of seeking health care for migraine: a population-based latent class analysis in Ontario, Canada\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\"},\"datePublished\":\"2026-08-05T01:49:51+00:00\",\"dateModified\":\"2026-08-11T01:54:56+00:00\",\"description\":\"Background \u2014 Comorbidity is common with migraine. 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