{"id":24328,"date":"2026-07-13T09:47:16","date_gmt":"2026-07-13T13:47:16","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=24328"},"modified":"2026-07-29T10:28:06","modified_gmt":"2026-07-29T14:28:06","slug":"risk-of-inguinal-hernia-repair-following-laparoscopic-living-donor-nephrectomy","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/risk-of-inguinal-hernia-repair-following-laparoscopic-living-donor-nephrectomy\/","title":{"rendered":"Risk of inguinal hernia repair following laparoscopic living donor nephrectomy: a population-based cohort study"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 A prior study of living kidney donors demonstrated a substantially higher long-term risk of hydrocelectomy among male living kidney donors who underwent laparoscopic nephrectomy compared with nondonors. Given the potential shared anatomical pathways between hydrocele and indirect inguinal hernia formation, we aimed to evaluate the donation-attributable risk of inguinal hernia repair.<\/p>\n<p><strong>Objective<\/strong> \u2014 To evaluate long-term rates of inguinal hernia repair in male living kidney donors compared to nondonors.<\/p>\n<p><strong>Design and setting<\/strong> \u2014 Population-based, retrospective matched cohort study using linked health administrative databases from Ontario, Canada.<\/p>\n<p><strong>Patients<\/strong> \u2014 848 male living kidney donors aged \u226518 years who underwent laparoscopic donor nephrectomy between April 1, 2002, and March 31, 2023, were matched (1:10) to 8480 healthy male nondonors based on age, cohort entry date, rurality, neighbourhood income, and prior vasectomy. Individuals with prior scrotal conditions or previous inguinal hernia repair were excluded.<\/p>\n<p><strong>Measurements<\/strong> \u2014 The primary outcome was inguinal hernia repair.<\/p>\n<p><strong>Methods<\/strong> \u2014 Risk was assessed using Cox proportional hazards models with robust variance. Cumulative incidence was estimated at key time points using Aalen\u2013Johansen methods, treating death as a competing event. To contextualize the findings, incidence rates were also examined after other renal (e.g., nondonor nephrectomy, pyeloplasty) and abdominal surgeries.<\/p>\n<p><strong>Results<\/strong> \u2014 Over a median follow-up of 8.8 years, 4.7% of donors (40 of 848) and 3.4% of nondonors (287 of 8480) underwent inguinal hernia repair. Donors had a modestly higher risk of undergoing inguinal hernia repair than nondonors (4.9 vs. 3.5 events per 1000 person-years; hazard ratio (HR) 1.40; 95% CI, 1.01\u20131.93; P = 0.043). The cumulative incidence of inguinal hernia repair after laparoscopic donor nephrectomy was comparable to that observed after other renal and abdominal surgeries.<\/p>\n<p><strong>Limitations<\/strong> \u2014 This study relied on administrative data, which lacked information on hernia type (direct or indirect), laterality, pre-existing asymptomatic hernias, and key confounders such as body mass index and occupation. Donors may differ from nondonors in care-seeking behaviours and lifestyle factors, which could influence the observed risk.<\/p>\n<p><strong>Conclusions<\/strong> \u2014 In contrast to the markedly higher risk of hydrocele repair, the donation-attributable risk of inguinal hernia repair in the years following laparoscopic donor nephrectomy appears modest, and in some comparisons was not evident. These findings support current counselling and selection practices for prospective donors, for which this outcome does not warrant specific consideration.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 A prior study of living kidney donors demonstrated a substantially higher long-term risk of hydrocelectomy among male living kidney donors who underwent laparoscopic nephrectomy compared with nondonors. Given the potential shared anatomical pathways between hydrocele and indirect inguinal hernia formation, we aimed to evaluate the donation-attributable risk of inguinal hernia repair. Objective \u2014 [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[49,54],"migration-helper-qa-sample-set":[],"class_list":["post-24328","journal_article","type-journal_article","status-publish","hentry","topic-kidney-disease","topic-organ-transplantation-and-donation"],"acf":{"citation":"Lyons R, McArthur E, Feldman LS, Lam N, Naylor KL, Nguan C, Quan D, Sener A, Sontrop JM, Garg AX. <em>Can J Kidney Health Dis<\/em>. 2026; 13: 20543581261468713.","source_url":"https:\/\/doi.org\/10.1177\/20543581261468713","ices_scientist":[1299,1242],"site":[6739],"research_program":[6743],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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