{"id":24048,"date":"2025-09-01T13:15:00","date_gmt":"2025-09-01T17:15:00","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=24048"},"modified":"2026-05-25T13:29:45","modified_gmt":"2026-05-25T17:29:45","slug":"the-association-of-adverse-pregnancy-outcomes-with-overactive-bladder-anticholinergics","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/the-association-of-adverse-pregnancy-outcomes-with-overactive-bladder-anticholinergics\/","title":{"rendered":"The association of adverse pregnancy outcomes with overactive bladder anticholinergics"},"content":{"rendered":"<p><strong>Importance<\/strong> \u2014 The pregnancy safety and teratogenicity of overactive bladder (OAB) anticholinergic medications in humans are unknown.<\/p>\n<p><strong>Objective<\/strong> \u2014 The aim of this study was to determine if the use of OAB anticholinergics during pregnancy was associated with adverse pregnancy outcomes or congenital malformation.<\/p>\n<p><strong>Study design<\/strong> \u2014 Using routinely collected health care data from Ontario, Canada, we conducted a retrospective cohort study and identified women aged 18\u201345 years who gave birth between 2004 and 2022 and were eligible for provincial drug benefits. We used gestational age and birth dates to approximate conception dates. The primary exposure was filling a prescription for an OAB anticholinergic during pregnancy (compared with nonusers). The coprimary outcomes were pregnancy complication (which included preterm birth or low birth weight) and congenital malformation. Poisson regression models with generalized estimating equations and inverse probability of treatment weighting were used to estimate risk ratios (RRs).<\/p>\n<p><strong>Results<\/strong> \u2014 We identified 138,271 births, of which 479 (0.3%) had exposure to an OAB anticholinergic, for a median of 60 (interquartile range, 30\u2013120) days. The most common OAB anticholinergic was oxybutynin (84%). In the weighted cohort, the risk of a pregnancy complication was significantly elevated (RR, 1.65; 95% confidence interval [CI], 1.40\u20131.95; P\u2009&lt;\u20090.01; absolute risk difference\u2009+\u20099.9% [95% CI, +5.9, +13.9]), with a dose-response relationship close to statistical significance (P\u2009=\u20090.07). The risk of congenital malformations with OAB anticholinergic use was not significant (RR, 1.24; 95% CI, 0.85\u20131.80; P\u2009=\u20090.26).<\/p>\n<p><strong>Conclusions<\/strong> \u2014 Pregnant women who take OAB anticholinergic medications have a higher risk of pregnancy complications, but not congenital malformations, compared with non-OAB anticholinergic users. This information can be used when counseling women of child-bearing age about these medications.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Importance \u2014 The pregnancy safety and teratogenicity of overactive bladder (OAB) anticholinergic medications in humans are unknown. Objective \u2014 The aim of this study was to determine if the use of OAB anticholinergics during pregnancy was associated with adverse pregnancy outcomes or congenital malformation. Study design \u2014 Using routinely collected health care data from Ontario, [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[26,56],"migration-helper-qa-sample-set":[],"class_list":["post-24048","journal_article","type-journal_article","status-publish","hentry","topic-maternity-and-neonatal-care","topic-pharmacoepidemiology-and-drug-safety"],"acf":{"citation":"Welk B, McClure JA, McArthur E, Leong Y. <em>Urogynecology (Phila)<\/em>. 2025; 31(9): 849-856.","source_url":"https:\/\/doi.org\/10.1097\/spv.0000000000001563","ices_scientist":[1131],"site":[6739],"research_program":[6743],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | The association of adverse pregnancy outcomes with overactive bladder anticholinergics<\/title>\n<meta name=\"description\" content=\"Importance \u2014 The pregnancy safety and teratogenicity of overactive bladder (OAB) anticholinergic medications in humans are unknown. 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