{"id":24010,"date":"2026-05-12T11:49:21","date_gmt":"2026-05-12T15:49:21","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=24010"},"modified":"2026-05-15T11:54:45","modified_gmt":"2026-05-15T15:54:45","slug":"contemporary-short-term-post-operative-outcomes-after-resection-of-entero-pancreatic-nets","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/contemporary-short-term-post-operative-outcomes-after-resection-of-entero-pancreatic-nets\/","title":{"rendered":"Contemporary short-term post-operative outcomes after resection of entero-pancreatic NETs: a population-based study"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 Surgery is a cornerstone of management for neuroendocrine tumors (NETs), but outcomes vary. It is critical to understand the real-world morbidity profile of surgery to optimize patient selection and outcomes. We examined short-term outcomes after resection for entero-pancreatic NETs.<\/p>\n<p><strong>Methods<\/strong> \u2014 We performed a population-based retrospective cohort study of adults with entero-pancreatic NETs (2000-2023). The outcome was 90-day major morbidity (Clavien-Dindo 3-5) and 90-day days-at-home after surgery (90-DAH). Logistic regression examined factors associated with outcomes for each type of surgery.<\/p>\n<p><strong>Results<\/strong> \u2014 Of 3699 surgeries for entero-pancreatic NETs, 30.5% involved a pancreatic primary, and 58.6% had metastases. 90-day major morbidity was 24.4% after all surgeries, including 26.9% after hepatectomy, 30.3% after pancreatectomy, 21.3% after enterectomy, and 30.4% after combined resection. 90-day mortality was 3.4% overall, with 4.0%, 1.7%, and 4.1% after hepatectomy, pancreatectomy, and enterectomy, respectively. Combined resection (OR 1.44; 95%CI 1.08-1.94) and pancreatoduodenectomy (OR 2.35; 95%CI 1.77-3.12), as well as age (OR 1.21; 95%CI 1.14-1.29) and higher comorbidity burden (OR 1.56; 95%CI 1.20-2.01) were independently associated with increased odds of 90-day major morbidity. Median DAH-90 was 82 (IQR: 77-84) overall and did not differ by surgery type. Combined hepatectomy, pancreatoduodenectomy, and higher comorbidity were independently associated with fewer 90-DAH.<\/p>\n<p><strong>Conclusion<\/strong> \u2014 Approximately 1 out of 4 patients experienced 90-day major morbidity after surgery for NETs and mortality below 5%. Most patients spent most of the time at home after surgery for NETs. This information is important to counsel patients, inform discussions about treatment options, and set expectations for post-operative recovery.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 Surgery is a cornerstone of management for neuroendocrine tumors (NETs), but outcomes vary. It is critical to understand the real-world morbidity profile of surgery to optimize patient selection and outcomes. We examined short-term outcomes after resection for entero-pancreatic NETs. Methods \u2014 We performed a population-based retrospective cohort study of adults with entero-pancreatic NETs [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[38,50,25],"migration-helper-qa-sample-set":[],"class_list":["post-24010","journal_article","type-journal_article","status-publish","hentry","topic-cancer-and-cancer-screening","topic-endocrinology","topic-surgery"],"acf":{"citation":"Meloche-Dumas L, Singh S, Law C, Chan WC, Ding A, Armah J, Hallet J. <em>Eur J Surg Oncol<\/em>. 2026; 52(7): 111877. Epub 2026 May 12.","source_url":"https:\/\/doi.org\/10.1016\/j.ejso.2026.111877","ices_scientist":[1353,1258],"site":[6733],"research_program":[6741],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Contemporary short-term post-operative outcomes after resection of entero-pancreatic NETs: a population-based study<\/title>\n<meta name=\"description\" content=\"Background \u2014 Surgery is a cornerstone of management for neuroendocrine tumors (NETs), but outcomes vary. 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