{"id":24002,"date":"2026-04-10T15:37:04","date_gmt":"2026-04-10T19:37:04","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=24002"},"modified":"2026-05-14T15:40:49","modified_gmt":"2026-05-14T19:40:49","slug":"donor-type-social-deprivation-and-longterm-outcomes-in-pediatric-liver-transplantation","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/donor-type-social-deprivation-and-longterm-outcomes-in-pediatric-liver-transplantation\/","title":{"rendered":"Donor type, social deprivation, and long\u2011term outcomes in pediatric liver transplantation: a 30\u2011year population\u2011based cohort"},"content":{"rendered":"<p>Living donor liver transplantation (LDLT) reduces wait\u2011list mortality in children, but its long\u2011term advantages over deceased donor liver transplantation (DDLT) and how socioeconomic context shapes outcomes in a universal healthcare system remain uncertain. We compared long\u2011term outcomes after pediatric LDLT versus DDLT and evaluated modification by socioeconomic status (SES). We linked clinical data for pediatric liver transplants in Ontario, Canada, from 1991 to 2021 to provincial health administrative data, yielding 449 recipients (189 LDLT, 260 DDLT) who underwent their first transplant. Over the 30-year period, LDLT recipients had superior patient and graft survival. After adjustment, DDLT was associated with a higher risk of mortality [adjusted hazard ratio (aHR) 2.1, 95% CI 1.0\u20134.3], graft failure (aHR 2.1, 95% CI 1.0\u20134.3), and chronic kidney disease (adjusted subdistribution HR 5.3, 95% CI 1.4\u201315.3), compared with LDLT. SES profoundly modified long-term outcomes: among DDLT recipients, lower neighborhood income and higher material deprivation were strongly linked to worse survival and increased graft loss. In contrast, LDLT moderated these socioeconomic disadvantages, with recipients showing comparable outcomes regardless of their SES (p for interaction &lt;0.01). In this population-based cohort study, LDLT was associated with significantly better long-term patient and graft survival and a lower risk of chronic kidney disease compared with DDLT. Socioeconomic disadvantage negatively impacted outcomes primarily among DDLT recipients, highlighting the need to improve equitable access to LDLT and to strengthen targeted post-transplant support for socioeconomically vulnerable families.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Living donor liver transplantation (LDLT) reduces wait\u2011list mortality in children, but its long\u2011term advantages over deceased donor liver transplantation (DDLT) and how socioeconomic context shapes outcomes in a universal healthcare system remain uncertain. We compared long\u2011term outcomes after pediatric LDLT versus DDLT and evaluated modification by socioeconomic status (SES). We linked clinical data for pediatric [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[16,54],"migration-helper-qa-sample-set":[],"class_list":["post-24002","journal_article","type-journal_article","status-publish","hentry","topic-children-and-young-people","topic-organ-transplantation-and-donation"],"acf":{"citation":"Yodoshi T, Kuenzig ME, Tang F, Kajiwara Saito M, Zizzo A, Ng VL, Benchimol EI. <em>Liver Transpl<\/em>. 2026; Apr 10 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.1097\/lvt.0000000000000877","ices_scientist":[21974,1174],"site":[6735],"research_program":[6740],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Donor type, social deprivation, and long\u2011term outcomes in pediatric liver transplantation: a 30\u2011year population\u2011based cohort<\/title>\n<meta name=\"description\" content=\"Living donor liver transplantation (LDLT) reduces wait\u2011list mortality in children, but its long\u2011term advantages over deceased donor liver transplantation\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/donor-type-social-deprivation-and-longterm-outcomes-in-pediatric-liver-transplantation\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Donor type, social deprivation, and long\u2011term outcomes in pediatric liver transplantation: a 30\u2011year 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