{"id":23983,"date":"2025-06-27T14:48:00","date_gmt":"2025-06-27T18:48:00","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=23983"},"modified":"2026-05-12T14:59:42","modified_gmt":"2026-05-12T18:59:42","slug":"association-of-polypharmacy-and-potentially-inappropriate-medications-with-outcomes-in-older-adults-with-dlbcl","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/association-of-polypharmacy-and-potentially-inappropriate-medications-with-outcomes-in-older-adults-with-dlbcl\/","title":{"rendered":"Association of polypharmacy and potentially inappropriate medications with outcomes in older adults with DLBCL: a population study"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 Polypharmacy and potentially inappropriate medications (PIMs) may be associated with survival and health care utilization in older patients undergoing treatment for diffuse large B-cell lymphoma (DLBCL).<\/p>\n<p><strong>Methods<\/strong> \u2014 This population-based study examined patients with DLBCL aged \u226566 years receiving rituximab-based therapy from January 1, 2006, to December 31, 2017, and followed them until March 31, 2019. Polypharmacy was defined as taking \u22655 or \u22658 concurrent medications within 90 days of treatment initiation. PIMs were assessed using the Anticholinergic Risk Scale (ARS) and the Geriatric Oncology Potentially Inappropriate Medications (GO-PIM) scale. Cox regression and negative binomial models were conducted, adjusting for age, sex, frailty, and comorbidity burden (Aggregated Diagnosis Groups [ADGs]). The primary outcome was all-cause mortality, and the secondary outcome was health care utilization, measured by unplanned emergency department visits and hospitalizations.<\/p>\n<p><strong>Results<\/strong> \u2014 A total of 5,527 patients were included (median age, 75 years; 48% female), of whom 69% and 40% had polypharmacy defined as \u22655 and \u22658 medications, respectively. In terms of PIMs, 27% of patients had at least one PIM based on ARS, whereas 70% had a high-risk medication based on the GO-PIM scale. Polypharmacy was associated with increased risk of all-cause mortality in the adjusted analysis, with an adjusted hazard ratio (aHR) of 1.14 (95% CI, 1.05\u20131.23; P=.0021) for patients taking \u22655 medications, and 1.18 (95% CI, 1.09\u20131.27; P&lt;.0001) for those taking \u22658 medications. Increasing number of PIMs was associated with increased mortality risk. Polypharmacy was associated with an increased relative risk of health care utilization, with an adjusted rate ratio (aRR) of 1.14 (95% CI, 1.06\u20131.22; P=.0004) for patients taking \u22655 medications, and 1.16 (95% CI, 1.08\u20131.24; P&lt;.0001) for those taking \u22658 medications. For PIMs, a higher score on the GO-PIM scale was associated with greater risk of health care utilization (aRR for \u22653 medications, 1.20; 95% CI, 1.09\u20131.32; P=.0003), whereas ARS was not.<\/p>\n<p><strong>Conclusions<\/strong> \u2014 Polypharmacy and PIMs are associated with an increased relative risk of mortality and health care utilization among older adults with DLBCL undergoing treatment, independent of frailty and comorbidity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 Polypharmacy and potentially inappropriate medications (PIMs) may be associated with survival and health care utilization in older patients undergoing treatment for diffuse large B-cell lymphoma (DLBCL). Methods \u2014 This population-based study examined patients with DLBCL aged \u226566 years receiving rituximab-based therapy from January 1, 2006, to December 31, 2017, and followed them until [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[38,56],"migration-helper-qa-sample-set":[],"class_list":["post-23983","journal_article","type-journal_article","status-publish","hentry","topic-cancer-and-cancer-screening","topic-pharmacoepidemiology-and-drug-safety"],"acf":{"citation":"Gong IY, Vijenthira A, Ante Z, Calzavara A, Hshieh TT, DuMontier C, Abel GA, Driver JA, Alibhai SMH, Prica A, Cheung MC, Mozessohn L. <em>J Natl Compr Canc Netw<\/em>. 2025; 23(8): e257029.","source_url":"https:\/\/doi.org\/10.6004\/jnccn.2025.7029","ices_scientist":[1193,1318],"site":[6733],"research_program":[6741],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Association of polypharmacy and potentially inappropriate medications with outcomes in older adults with DLBCL: a population study<\/title>\n<meta name=\"description\" content=\"Background \u2014 Polypharmacy and potentially inappropriate medications (PIMs) may be associated with survival and health care utilization in older patients\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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