{"id":23980,"date":"2025-02-01T13:57:00","date_gmt":"2025-02-01T18:57:00","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&p=23980"},"modified":"2026-05-12T14:06:39","modified_gmt":"2026-05-12T18:06:39","slug":"a-prognostic-symptom-model-incorporating-patient-reported-symptoms-for-transplant-ineligible-patients-with-multiple-myeloma","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/a-prognostic-symptom-model-incorporating-patient-reported-symptoms-for-transplant-ineligible-patients-with-multiple-myeloma\/","title":{"rendered":"A prognostic symptom model incorporating patient-reported symptoms for transplant-ineligible patients with multiple myeloma"},"content":{"rendered":"

Introduction<\/strong> \u2014 Patients with transplant-ineligible (TIE) multiple myeloma (MM) have high rates of symptom burden. The aim of this study was to develop and validate a prognostic model to predict symptoms in patients with TIE MM.<\/p>\n

Methods<\/strong> \u2014 In this population-based, retrospective cohort study, using multiple administrative health care databases linked using a unique encrypted patient identifier in Ontario, Canada, symptoms were identified using the patient self-reported Edmonton Symptom Assessment System (ESAS) at each clinic visit. The primary outcome was the presence of moderate-to-severe (ESAS score 4\u201310) symptoms (specifically symptoms of pain, tiredness, depression, and impaired well-being) within one year from the index date. Using the entire cohort, a multivariable logistic regression model with baseline covariates was developed to predict the risk of experiencing each of the above symptoms, categorized as moderate to severe within 1 year post-index date. Internal validation of the model was assessed via bootstrap validation methods.<\/p>\n

Results<\/strong> \u2014 A total of 1535 TIE adults with MM met the inclusion criteria. The median age was 75, with 25.2% of patients aged 80 years or older. In the multivariate analysis, baseline symptoms continued to be most associated with future symptom burden. Baseline severe pain (OR 9.84, 95% CI 6.29\u201315.7) was most associated with patients experiencing moderate\u2013severe pain one year post-index date. Similarly, baseline severe tiredness (OR 17.34, 95% CI 9.00\u201333.42), baseline severe depression (OR 28.07, 95% CI 15.96\u201349.38), and baseline severely impaired well-being (OR 4.12, 95% CI 2.30\u20137.37) were the biggest predictors of patients experiencing moderate\u2013severe tiredness, depression, and impaired well-being, respectively, at one year after the index date.<\/p>\n

Conclusions<\/strong> \u2014 Patients with MM experience persisting symptoms of pain, tiredness, depression, and impaired well-being, with baseline symptoms being the biggest predictor of future symptom burden.<\/p>\n","protected":false},"excerpt":{"rendered":"

Introduction \u2014 Patients with transplant-ineligible (TIE) multiple myeloma (MM) have high rates of symptom burden. The aim of this study was to develop and validate a prognostic model to predict symptoms in patients with TIE MM. Methods \u2014 In this population-based, retrospective cohort study, using multiple administrative health care databases linked using a unique encrypted […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[38],"migration-helper-qa-sample-set":[],"class_list":["post-23980","journal_article","type-journal_article","status-publish","hentry","topic-cancer-and-cancer-screening"],"acf":{"citation":"Balitsky AK, Sutradhar R, Seow H, Gayowsky A, Visram A, Tay J, Sandhu I, Mian H. 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