{"id":23408,"date":"2026-03-13T11:14:45","date_gmt":"2026-03-13T15:14:45","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&p=23408"},"modified":"2026-03-17T11:21:58","modified_gmt":"2026-03-17T15:21:58","slug":"periprosthetic-joint-infection-following-total-knee-arthroplasty-is-associated-with-a-significantly-elevated-risk-of-mortality","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/periprosthetic-joint-infection-following-total-knee-arthroplasty-is-associated-with-a-significantly-elevated-risk-of-mortality\/","title":{"rendered":"Periprosthetic joint infection following total knee arthroplasty is associated with a significantly elevated risk of mortality: a population-level database study"},"content":{"rendered":"

Background<\/strong> \u2014 Periprosthetic joint infection (PJI) is the most common reason for revision total knee arthroplasty (TKA). Recent evidence has demonstrated that patients who develop PJI within 1 year following total hip arthroplasty have a significantly elevated risk of mortality within 10 years. Thus, the aim of this study was to compare long-term mortality rates between patients who did and did not develop PJI within 1 year following the index TKA.<\/p>\n

Methods<\/strong> \u2014 This was a retrospective population-level database study. All eligible participants interacted with a single-payer public health-care system. The primary outcome measure was mortality at 10 years following index TKA; 1- and 5-year mortality were also compared. Mortality was compared for propensity-score-matched groups.<\/p>\n

Results<\/strong> \u2014 Of the total of 263,204 patients who underwent primary TKA in the study period (mean age and standard deviation, 67.9 \u00b1 9.3 years), 1,228 (0.5%) subsequently developed PJI within 1 year. Across the entire sample, patients who developed PJI within 1 year following the index TKA were more likely to be male, have frailty, and have a Charlson-Deyo score of >0; they also had significantly higher rates of congestive heart failure and chronic obstructive pulmonary disease compared with those who did not develop PJI within 1 year. A total of 1,202 patients who developed PJI within 1 year of the index TKA were matched to 1,202 patients who did not develop PJI within 1 year of the index TKA, with standardized differences of <0.10 for all covariates, indicating a robust match. After matching, TKA recipients who developed PJI in the first year had a significantly higher 10-year mortality rate (7.2% [86] versus 1.6% [19]; absolute risk difference = 5.45% [95% confidence interval (CI) = 3.41% to 7.74%]; hazard ratio = 4.66 [95% CI = 2.84 to 7.66]).<\/p>\n

Conclusions<\/strong> \u2014 Patients who developed PJI within 1 year following TKA were at significantly higher risk for mortality at 10 years post-TKA compared with those who did not develop PJI within 1 year following TKA. The etiological factors leading to this increased risk remain unclear and warrant further investigation alongside efforts to further the prevention, diagnosis, and management of PJI.<\/p>\n","protected":false},"excerpt":{"rendered":"

Background \u2014 Periprosthetic joint infection (PJI) is the most common reason for revision total knee arthroplasty (TKA). Recent evidence has demonstrated that patients who develop PJI within 1 year following total hip arthroplasty have a significantly elevated risk of mortality within 10 years. Thus, the aim of this study was to compare long-term mortality rates […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[62,51],"migration-helper-qa-sample-set":[],"class_list":["post-23408","journal_article","type-journal_article","status-publish","hentry","topic-health-services-research","topic-musculoskeletal-diseases-and-disorders"],"acf":{"citation":"Ekhtiari S, Mundi R, Pincus D, Schemitsch E, Paterson JM, Chaudhry H, Leis JA, Redelmeier D, Ravi B. J Bone Joint Surg Am<\/em>. 2026; Mar 13 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.2106\/jbjs.25.00177","ices_scientist":[1100,1337,1333],"site":[6733],"research_program":[6746],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"\nICES | Periprosthetic joint infection following total knee arthroplasty is associated with a significantly elevated risk of mortality: a population-level database study<\/title>\n<meta name=\"description\" content=\"Background \u2014 Periprosthetic joint infection (PJI) is the most common reason for revision total knee arthroplasty (TKA). 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