{"id":23124,"date":"2026-01-15T11:25:38","date_gmt":"2026-01-15T16:25:38","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=23124"},"modified":"2026-01-20T11:29:08","modified_gmt":"2026-01-20T16:29:08","slug":"migraine-comorbidity-and-risks-of-severe-maternal-and-neonatal-morbidity-or-mortality","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/migraine-comorbidity-and-risks-of-severe-maternal-and-neonatal-morbidity-or-mortality\/","title":{"rendered":"Migraine, comorbidity, and risks of severe maternal and neonatal morbidity or mortality: a population-based cohort study"},"content":{"rendered":"<p>Migraine is a neurological disease associated with adverse perinatal outcomes. We examined the separate and combined impacts of migraine and comorbidity on risks of severe maternal morbidity\/mortality (SMM-M) and severe neonatal morbidity\/mortality (SNM-M). This population-based cohort study of pregnancies (n=2,643,335) in Ontario, Canada, 2007-2022, compared females with (1) pre-pregnancy migraine and \u22651 other chronic conditions, (2) migraine alone, (3) other chronic conditions alone, and (4) neither migraine\/other chronic conditions (referent) using modified Poisson regression. Attributable proportion due to interaction (aAP) reflected additive interaction between migraine and comorbidity. In the cohort, 6.8% had migraine and other chronic conditions, 3.2% migraine alone, 45.7% other chronic conditions alone, and 44.3% neither. The incidence of SMM-M was 1.6%, while SNM-M affected 7.1% of neonates. Risks of SMM-M and SNM-M were greatest in those doubly exposed (aRRSMM-M 1.60, 95% CI 1.54-1.66; aRRSNM-M 1.43, 1.39-1.46), followed by other chronic conditions alone (aRRSMM-M 1.34, 1.32-1.37; aRRSNM-M 1.30, 1.28-1.32), and migraine alone (aRRSMM-M 1.13, 1.07-1.20; aRRSNM-M 1.07, 1.04-1.11). Additive interaction was small for SMM-M (aAP 7.4%, 2.2-12.5) and SNM-M (aAP 3.7%, 0.3-6.9). Although synergistic effects were small, findings suggest individuals with migraine and comorbidity could benefit from preconception and perinatal supports to reduce their risks of perinatal complications.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Migraine is a neurological disease associated with adverse perinatal outcomes. We examined the separate and combined impacts of migraine and comorbidity on risks of severe maternal morbidity\/mortality (SMM-M) and severe neonatal morbidity\/mortality (SNM-M). This population-based cohort study of pregnancies (n=2,643,335) in Ontario, Canada, 2007-2022, compared females with (1) pre-pregnancy migraine and \u22651 other chronic conditions, [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[41,42,26],"migration-helper-qa-sample-set":[],"class_list":["post-23124","journal_article","type-journal_article","status-publish","hentry","topic-brain-diseases","topic-chronic-diseases-and-multimorbidity","topic-maternity-and-neonatal-care"],"acf":{"citation":"Albanese CM, Bondy SJ, Lay C, Vyas MV, Li Z, Guan J, Brown HK. <em>Am J Epidemiol<\/em>. 2026; Jan 15 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.1093\/aje\/kwag008","ices_scientist":[1179,1118,1164],"site":[6733],"research_program":[6740],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Migraine, comorbidity, and risks of severe maternal and neonatal morbidity or mortality: a population-based cohort study<\/title>\n<meta name=\"description\" content=\"Migraine is a neurological disease associated with adverse perinatal outcomes. 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