{"id":23069,"date":"2025-12-28T10:35:00","date_gmt":"2025-12-28T15:35:00","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=23069"},"modified":"2026-01-07T10:51:09","modified_gmt":"2026-01-07T15:51:09","slug":"validity-of-the-leading-causes-of-death-classification-for-premature-mortality-in-inflammatory-bowel-disease","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/validity-of-the-leading-causes-of-death-classification-for-premature-mortality-in-inflammatory-bowel-disease\/","title":{"rendered":"Validity of the leading causes of death classification for premature mortality in inflammatory bowel disease: a population-based comparison with ICD-10 coding in Ontario, Canada"},"content":{"rendered":"<p><strong>Introduction<\/strong> \u2014 Studying patterns of death, particularly premature deaths (&lt; 75 years), provides insights to address health inequities among those living. Multiple coding systems for cause of death (COD) exist. The Leading Causes of Death (LCD) scheme is designed for identifying priority COD for interventions in global populations. The extent to which such classification is effective for identifying priority causes of premature mortality among subpopulations with chronic health conditions, such as inflammatory bowel disease (IBD), is unknown.<\/p>\n<p><strong>Objective<\/strong> \u2014 To evaluate the usability of the LCD for characterizing premature mortality among those with IBD.<\/p>\n<p><strong>Methods<\/strong> \u2014 We conducted a population-based matched case control study of persons with IBD who died between 2010 and 2018 using linked health administrative data from Ontario, Canada. Individuals with IBD were matched with five decedents without IBD based on sex and years of birth and death. We compared COD for premature and overall mortality using two classification structures: the LCD scheme and the International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10) chapters.<\/p>\n<p><strong>Results<\/strong> \u2014 Among 7,919 decedents with IBD (39,414 matched controls), 47% died prematurely. With the LCD framework, COD differences for premature mortality were not detectable as 29% were allocated to the residual category (Standardized differences [SD]: 18%). Most residual deaths were due to neoplasms (34%) or diseases of the gastrointestinal system (32%). Using ICD-10 chapters, premature deaths were more commonly due to diseases of the digestive system than for matched controls (13% vs 5%, SD: 31%).<\/p>\n<p><strong>Discussion<\/strong> \u2014 The LCD coding scheme provides more granular COD details compared to the ICD-10 chapters. However, a larger proportion of deaths among people with IBD were allocated to the residual category, limiting its utility for enabling healthcare systems to identify priority targets to reduce premature mortality. Further work to develop and validate a framework for premature COD classification in populations with IBD is needed.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Introduction \u2014 Studying patterns of death, particularly premature deaths (&lt; 75 years), provides insights to address health inequities among those living. Multiple coding systems for cause of death (COD) exist. The Leading Causes of Death (LCD) scheme is designed for identifying priority COD for interventions in global populations. The extent to which such classification is [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[42,59,48],"migration-helper-qa-sample-set":[],"class_list":["post-23069","journal_article","type-journal_article","status-publish","hentry","topic-chronic-diseases-and-multimorbidity","topic-data-science","topic-gastroenterology"],"acf":{"citation":"Postill G, Kuenzig ME, Olivera PA, Itanyi IU, Harish V, Tang F, Buajitti E, Rosella LC, Benchimol EI. <em>Clin Epidemiol<\/em>. 2025; 17:1163-1175.","source_url":"https:\/\/doi.org\/10.2147\/clep.s546090","ices_scientist":[21974,1339,1174],"site":[6735],"research_program":[6740],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Validity of the leading causes of death classification for premature mortality in inflammatory bowel disease: a population-based comparison with ICD-10 coding in Ontario, Canada<\/title>\n<meta name=\"description\" content=\"Introduction \u2014 Studying patterns of death, particularly premature deaths (&lt; 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