{"id":23067,"date":"2025-12-22T09:37:18","date_gmt":"2025-12-22T14:37:18","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&p=23067"},"modified":"2026-01-07T10:26:38","modified_gmt":"2026-01-07T15:26:38","slug":"clinical-characteristics-and-outcomes-of-critically-ill-adult-patients-admitted-with-traumatic-brain-injury","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/clinical-characteristics-and-outcomes-of-critically-ill-adult-patients-admitted-with-traumatic-brain-injury\/","title":{"rendered":"Clinical characteristics and outcomes of critically ill adult patients admitted with traumatic brain injury: a cohort study"},"content":{"rendered":"

Purpose<\/strong> \u2014 We sought to describe the clinical features and outcomes of adult patients with traumatic brain injury in Ontario.<\/p>\n

Methods<\/strong> \u2014 We carried out a cohort study of adult patients admitted to an intensive care unit (April 2009 to March 2021) with a first episode of traumatic brain injury. To compare the long-term outcome trajectory after traumatic brain injury, we matched patients with traumatic brain injury 1:1 to patients who survived an intensive care unit admission with multisystem trauma but without traumatic brain injury. We measured in-hospital and long-term all-cause mortality; additional endpoints included 1) new psychiatric diagnosis, 2) epilepsy, 3) venous thromboembolic disease, and 4) sepsis. We estimated hazard ratios (HR) with 95% confidence intervals (CI).<\/p>\n

Results<\/strong> \u2014 Overall, we included 13,283 adult patients with traumatic brain injury. The mean age was 54\u2009yr; 72% of patients were male. The most common pre-existing comorbidities were hypertension (39%) and cardiovascular disease (19%). Median follow-up was 5 years; 17% of patients with traumatic brain injury died during their initial hospital stay, and 16% died during long-term follow-up. Sepsis after hospital discharge occurred in 14% of patients; additional outcomes included new psychiatric diagnosis (7%), epilepsy (4%), and venous thromboembolic disease (2%). Surviving traumatic brain injury was associated with a higher hazard of epilepsy (HR, 2.42; 95% CI, 1.99 to 2.95); the risk of other outcomes was similar or lower when compared with survivors without traumatic brain injury.<\/p>\n

Conclusions<\/strong> \u2014 Patients with traumatic brain injury have a high risk of in-hospital death. Those who survive the initial hospitalization are at risk of long-term outcomes including new epilepsy.<\/p>\n","protected":false},"excerpt":{"rendered":"

Purpose \u2014 We sought to describe the clinical features and outcomes of adult patients with traumatic brain injury in Ontario. Methods \u2014 We carried out a cohort study of adult patients admitted to an intensive care unit (April 2009 to March 2021) with a first episode of traumatic brain injury. To compare the long-term outcome […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[41,55],"migration-helper-qa-sample-set":[],"class_list":["post-23067","journal_article","type-journal_article","status-publish","hentry","topic-brain-diseases","topic-injuries-and-accidents"],"acf":{"citation":"Angriman F, Angeloni NA, Tanenbaum B, Hernandez A, Adhikari NKJ, Scales DC. Can J Anaesth<\/em>. 2025; Dec 22 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.1007\/s12630-025-03057-4","ices_scientist":[1364],"site":[6733],"research_program":[6747],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"\nICES | Clinical characteristics and outcomes of critically ill adult patients admitted with traumatic brain injury: a cohort study<\/title>\n<meta name=\"description\" content=\"Purpose \u2014 We sought to describe the clinical features and outcomes of adult patients with traumatic brain injury in Ontario. 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