{"id":22774,"date":"2025-11-11T09:45:06","date_gmt":"2025-11-11T14:45:06","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&p=22774"},"modified":"2025-11-11T09:45:08","modified_gmt":"2025-11-11T14:45:08","slug":"risk-for-scrotal-surgery-after-laparoscopic-donor-nephrectomy","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/risk-for-scrotal-surgery-after-laparoscopic-donor-nephrectomy\/","title":{"rendered":"Risk for scrotal surgery after laparoscopic donor nephrectomy:\u00a0a population-based cohort study"},"content":{"rendered":"

Background<\/strong> \u2014 A potential long-term complication of living kidney donation in male donors is scrotal swelling on the same side as the nephrectomy, and some undergo surgery to relieve discomfort from the fluid collection. The long-term risk for this outcome attributable to donation is unknown.<\/p>\n

Objective<\/strong> \u2014 To evaluate long-term scrotal surgery rates after laparoscopic nephrectomy in male living kidney donors compared with nondonors.<\/p>\n

Design<\/strong> \u2014 Population-based cohort study (2002 to 2024). (ClinicalTrials.gov: NCT06716723)<\/p>\n

Setting<\/strong> \u2014 Linked administrative health care databases in Ontario, Canada.<\/p>\n

Participants<\/strong> \u2014 898 male living kidney donors who had a laparoscopic nephrectomy were matched in a 1:10 ratio with 8980 male nondonors from the general population. The matching characteristics were age, date of cohort entry, rural residence, income, prior vasectomy, and prior inguinal hernia repair. Participants were followed for a median of 9 years, up to 22 years.<\/p>\n

Measurements<\/strong> \u2014 The primary outcome was hospitalization for surgery to address a unilateral scrotal fluid collection.<\/p>\n

Results<\/strong> \u2014 Donors and matched nondonors had a median age of 45 years. The rate of scrotal surgery was higher in donors than nondonors (70 of 898 donors [7.8%] vs. 19 of 8980 nondonors [0.2%]; 8.3 vs. 0.2 events per 1000 person-years; hazard ratio, 38.8 [95% CI, 22.1 to 67.9]; P < 0.001). The median time from donation to scrotal surgery was 5.2 years (IQR, 3.3 to 8.4 years); more than 90% of the surgeries were hydrocelectomies and were performed under general anesthesia. Over 20 years, the cumulative incidence was 13.8% in donors versus 0.7% in nondonors.<\/p>\n

Limitation<\/strong> \u2014 The precise causal mechanism remains unknown.<\/p>\n

Conclusion<\/strong> \u2014 Laparoscopic nephrectomy is associated with a higher risk for subsequent scrotal surgery in male living kidney donors.<\/p>\n","protected":false},"excerpt":{"rendered":"

Background \u2014 A potential long-term complication of living kidney donation in male donors is scrotal swelling on the same side as the nephrectomy, and some undergo surgery to relieve discomfort from the fluid collection. The long-term risk for this outcome attributable to donation is unknown. Objective \u2014 To evaluate long-term scrotal surgery rates after laparoscopic […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[62,54,25],"migration-helper-qa-sample-set":[],"class_list":["post-22774","journal_article","type-journal_article","status-publish","hentry","topic-health-services-research","topic-organ-transplantation-and-donation","topic-surgery"],"acf":{"citation":"Garg AX, McArthur E, Sontrop JM, Boudville N, Connaughton DM, Cuerden MS, Feldman LS, Lam NN, Lentine KL, Nguan C, Parikh CR, Segev DL, Sener A, Smith G, Wang C, Weir MA, Yohanna S, Young A, Naylor KL. Ann Intern Med<\/em>. 2025; Nov 11 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.7326\/ANNALS-25-02257","ices_scientist":[1242,1127,16595,1299],"site":[6739],"research_program":[6743],"news_release":[22784],"journal_article":"","atlas":"","research_report":"","infographic":[22782],"video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"\nICES | Risk for scrotal surgery after laparoscopic donor nephrectomy:\u00a0a population-based cohort study<\/title>\n<meta name=\"description\" content=\"Background \u2014 A potential long-term complication of living kidney donation in male donors is scrotal swelling on the same side as the nephrectomy, and some\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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