{"id":22584,"date":"2025-10-06T13:10:35","date_gmt":"2025-10-06T17:10:35","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=22584"},"modified":"2025-10-08T13:27:07","modified_gmt":"2025-10-08T17:27:07","slug":"effect-of-sustained-virologic-response-on-liver-related-mortality-among-individuals-living-with-hepatitis-c-by-treatment-era","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/effect-of-sustained-virologic-response-on-liver-related-mortality-among-individuals-living-with-hepatitis-c-by-treatment-era\/","title":{"rendered":"Effect of sustained virologic response on liver-related mortality among individuals living with hepatitis C by treatment era: a population-based retrospective cohort study"},"content":{"rendered":"<p><strong>Purpose<\/strong> \u2014 Sustained virologic response (SVR) is a validated surrogate marker for successful hepatitis C virus (HCV) treatment. Historically, interferon-based therapies, the standard of care for decades, offered only limited efficacy with respect to SVR. The recent introduction of highly effective direct-acting antivirals (DAAs) revolutionised treatment, expanding treatment eligibility among individuals with advanced liver disease (ALD) and drug\/alcohol-related substance use disorder. Given these clinical policy shifts, we assessed the real-world impact of SVR on liver-related death for these key clinical groups for whom treatment had previously been less feasible.<\/p>\n<p><strong>Methods<\/strong> \u2014 We conducted a population-based, cohort study of Ontario residents with HCV viremia between January 1st, 1999, and December 31st, 2018, with follow-up to May 31st, 2021 (N\u2009=\u200973,411) and used cause-specific hazard models to explore the association between SVR and liver-related death.<\/p>\n<p><strong>Results<\/strong> \u2014 SVR was associated with a significant reduction in liver-related deaths (adjusted hazard ratio [aHR]: 0.22, 95%CI: 0.20\u20130.24). This benefit was consistent across all levels of liver disease severity, including individuals with (aHR: 0.11, 95%CI: 0.06\u20130.18) and without (aHR: 0.13, 95%CI: 0.10\u20130.17) cirrhosis, individuals with ALD (aHR: 0.24, 95%CI: 0.22\u20130.27) as well as among individuals with (aHR: 0.24, 95%CI: 0.21\u20130.27) and without (aHR: 0.21, 95%CI: 0.18\u20130.24) substance use disorder.<\/p>\n<p><strong>Conclusions<\/strong> \u2014 This study demonstrates the real-world impact of SVR on liver-related mortality and highlights the value of early treatment and continued support for populations who are marginalised.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Purpose \u2014 Sustained virologic response (SVR) is a validated surrogate marker for successful hepatitis C virus (HCV) treatment. Historically, interferon-based therapies, the standard of care for decades, offered only limited efficacy with respect to SVR. The recent introduction of highly effective direct-acting antivirals (DAAs) revolutionised treatment, expanding treatment eligibility among individuals with advanced liver disease [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[48,39,56],"migration-helper-qa-sample-set":[],"class_list":["post-22584","journal_article","type-journal_article","status-publish","hentry","topic-gastroenterology","topic-infectious-diseases","topic-pharmacoepidemiology-and-drug-safety"],"acf":{"citation":"Erman A, Everett K, Wong WWL, Forouzannia F, Greenaway C, Janjua N, Kwong JC, Sander B. <em>PLoS One<\/em>. 2025; 20(10):e0333584.","source_url":"https:\/\/doi.org\/10.1371\/journal.pone.0333584","ices_scientist":[1120,1149,1362],"site":[6733],"research_program":[6745],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Effect of sustained virologic response on liver-related mortality among individuals living with hepatitis C by treatment era: a population-based retrospective cohort study<\/title>\n<meta name=\"description\" content=\"Purpose \u2014 Sustained virologic response (SVR) is a validated surrogate marker for successful hepatitis C virus (HCV) treatment. 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