{"id":22343,"date":"2025-07-23T16:46:44","date_gmt":"2025-07-23T20:46:44","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&p=22343"},"modified":"2025-09-08T16:52:12","modified_gmt":"2025-09-08T20:52:12","slug":"cholesterol-levels-and-cardiovascular-outcomes-following-statin-initiation-for-primary-prevention","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/cholesterol-levels-and-cardiovascular-outcomes-following-statin-initiation-for-primary-prevention\/","title":{"rendered":"Cholesterol levels and cardiovascular outcomes following statin initiation for primary prevention: a cohort study"},"content":{"rendered":"

Background<\/strong> \u2014 Non-high-density lipoprotein cholesterol (HDL-C) is increasingly incorporated into guidelines along with low-density lipoprotein cholesterol (LDL-C) to guide lipid-lowering therapy decisions.<\/p>\n

Objectives<\/strong> \u2014 The purpose of this study was to examine patterns of LDL-C and non-HDL-C levels after statin initiation for primary prevention and their association with incident cardiovascular events.<\/p>\n

Methods<\/strong> \u2014 This was a population-based cohort study in Ontario, Canada, among persons aged \u226566 years starting a statin for primary prevention between January 1, 2012, and December 31, 2019. We identified those with a lipid panel in the 1-year after starting a statin and categorized individuals based on LDL-C and non-HDL-C thresholds for intensification in the 2021 Canadian Cardiovascular Society dyslipidemia guidelines. We stratified by diabetes\/chronic kidney disease (CKD) status. The primary outcome was the composite of all-cause mortality or cardiovascular events, with follow-up to December 31, 2020. We used a Cox proportional hazards model for analysis.<\/p>\n

Results<\/strong> \u2014 Our cohort comprised 125,013 people. The median follow-up was 2.5 years. Compared with those meeting both LDL-C and non-HDL-C thresholds, being above both thresholds was associated with an increased rate of the primary outcome for people without diabetes\/CKD (HR: 1.10; 95% CI: 1.05-1.15) and for those with diabetes\/CKD (HR: 1.16; 95% CI: 1.09-1.23). Being below the LDL-C threshold but above non-HDL-C threshold was associated with an increased rate of the primary outcome for people with diabetes\/CKD (HR: 1.16; 95% CI: 1.03-1.30).<\/p>\n

Conclusions<\/strong> \u2014 These findings support the residual risk associated with incompletely controlled LDL-C or non-HDL-C levels after statin initiation for primary prevention.<\/p>\n","protected":false},"excerpt":{"rendered":"

Background \u2014 Non-high-density lipoprotein cholesterol (HDL-C) is increasingly incorporated into guidelines along with low-density lipoprotein cholesterol (LDL-C) to guide lipid-lowering therapy decisions. Objectives \u2014 The purpose of this study was to examine patterns of LDL-C and non-HDL-C levels after statin initiation for primary prevention and their association with incident cardiovascular events. Methods \u2014 This was […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[40,56],"migration-helper-qa-sample-set":[],"class_list":["post-22343","journal_article","type-journal_article","status-publish","hentry","topic-cardiovascular-disease","topic-pharmacoepidemiology-and-drug-safety"],"acf":{"citation":"Thompson W, Jeong I, Basque S, Abdel-Qadir H, Austin PC, Ko DT, Famiyeh I, Chu A, Fang J, Odutayo A, Jackevicius CA, Godoy LC, Lee DS, Anderson TJ, Udell JA. JACC Adv<\/em>. 2025; 4(7):101864.","source_url":"https:\/\/doi.org\/10.1016\/j.jacadv.2025.101864","ices_scientist":[1379,1385,1146,1281,1290,1346],"site":[6733],"research_program":[6742],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"\nICES | Cholesterol levels and cardiovascular outcomes following statin initiation for primary prevention: a cohort study<\/title>\n<meta name=\"description\" content=\"Background \u2014 Non-high-density lipoprotein cholesterol (HDL-C) is increasingly incorporated into guidelines along with low-density lipoprotein cholesterol\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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