{"id":22326,"date":"2025-08-29T13:23:13","date_gmt":"2025-08-29T17:23:13","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&p=22326"},"modified":"2025-09-03T16:22:21","modified_gmt":"2025-09-03T20:22:21","slug":"association-of-albuminuria-with-1-year-risk-of-heart-failure-and-other-adverse-outcomes-in-atrial-fibrillation","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/association-of-albuminuria-with-1-year-risk-of-heart-failure-and-other-adverse-outcomes-in-atrial-fibrillation\/","title":{"rendered":"Association of albuminuria with 1-year risk of heart failure and other adverse outcomes in atrial fibrillation"},"content":{"rendered":"

Background<\/strong> \u2014 Albuminuria is associated with increased stroke risk in atrial fibrillation (AF), but its relationship with heart failure (HF) and other adverse outcomes in AF is less well understood.<\/p>\n

Methods<\/strong> \u2014 Using linked administrative databases, we conducted a retrospective cohort study of individuals aged \u226566\u2009years who were newly diagnosed with AF between April 2009 and March 2019 in Ontario, Canada. Albuminuria was assessed using (1) urine albumin\u2010to\u2010creatinine ratio (UACR, mg\/g) and (2) dipstick proteinuria (negative, trace, 1+, 2+, \u22653+). Cause\u2010specific hazards regression estimated adjusted hazard ratios (HRs) for HF hospitalizations or emergency department visits, stroke hospitalizations, bleeding hospitalizations, and death over 1\u2009year.<\/p>\n

Results<\/strong> \u2014 We included 64\u2009717 individuals with UACR data and 110\u2009430 with dipstick proteinuria data. Relative to UACR 5\u2009mg\/g, the HRs for UACR 30\u2009mg\/g (below the microalbuminuria threshold) were 1.39 (95% CI, 1.28\u20131.50) for HF, 1.22 (95% CI, 1.07\u20131.40) for bleeding, and 1.35 (95% CI, 1.27\u20131.42) for death. A UACR of 30\u2009mg\/g versus 5\u2009mg\/g was associated with an HR of 1.16 (95% CI, 0.99\u20131.36) for stroke but the HR was significantly elevated at UACR values \u226565\u2009mg\/g. Increasing dipstick proteinuria was also associated with increases in the HR for adverse outcomes. A UACR of 30\u2009mg\/g was associated with greater HF risk (versus 5\u2009mg\/g) than all CHA\u2082DS\u2082VASc components except age >75 years and prior HF.<\/p>\n

Conclusions<\/strong> \u2014 Albuminuria is associated with increased hazards of HF, stroke, bleeding, and death in patients with AF even at low UACR levels. Albuminuria may enhance risk stratification in AF beyond traditional scores.<\/p>\n","protected":false},"excerpt":{"rendered":"

Background \u2014 Albuminuria is associated with increased stroke risk in atrial fibrillation (AF), but its relationship with heart failure (HF) and other adverse outcomes in AF is less well understood. Methods \u2014 Using linked administrative databases, we conducted a retrospective cohort study of individuals aged \u226566\u2009years who were newly diagnosed with AF between April 2009 […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[40],"migration-helper-qa-sample-set":[],"class_list":["post-22326","journal_article","type-journal_article","status-publish","hentry","topic-cardiovascular-disease"],"acf":{"citation":"Odutayo A, Serrano A, Chauhan A, Fang J, Sud M, Han L, Austin PC, Dorian P, Jackevicius CA, Lee DS, Singh SM, Tu K, Ko DT, Abdel-Qadir H. J Am Heart Assoc<\/em>. 2025; 14(17):e041185. Epub 2025 Aug 29.","source_url":"https:\/\/doi.org\/10.1161\/jaha.125.041185","ices_scientist":[1385,1281,1290,1146],"site":[6733],"research_program":[6742],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"\nICES | Association of albuminuria with 1-year risk of heart failure and other adverse outcomes in atrial fibrillation<\/title>\n<meta name=\"description\" content=\"Background \u2014 Albuminuria is associated with increased stroke risk in atrial fibrillation (AF), but its relationship with heart failure (HF) and other\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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