{"id":22043,"date":"2025-04-23T18:33:26","date_gmt":"2025-04-23T22:33:26","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=22043"},"modified":"2025-07-02T20:09:09","modified_gmt":"2025-07-03T00:09:09","slug":"prenatal-exposure-to-fine-particulate-matter-composition-and-risk-of-cerebral-palsy","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/prenatal-exposure-to-fine-particulate-matter-composition-and-risk-of-cerebral-palsy\/","title":{"rendered":"Prenatal exposure to fine particulate matter composition and risk of cerebral palsy: a population-based retrospective cohort study in Ontario, Canada"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 Existing literature suggests an association between prenatal exposure to fine particulate air pollution (PM2.5) and cerebral palsy (CP). However, the impact of individual PM2.5 components (SO42\u2212, NH4+, NO3\u2212, SS, BC, dust, OM) on CP risk remains unknown.<\/p>\n<p><strong>Objective<\/strong> \u2014 To examine the associations between prenatal exposure to PM2.5 components, and risk of CP among term births in Ontario, Canada.<\/p>\n<p><strong>Methods<\/strong> \u2014 This was a retrospective cohort study that examined term births (gestational age \u226537 completed weeks) from April 2002 to December 2020. PM2.5 total mass and composition measures were assigned to maternal residence at birth using satellite-based estimates and ground-level monitoring data. Cohort data were compiled using health administrative databases. Single-pollutant distributed lag cox proportional hazard models, with and without additional adjustment for PM2.5 residuals, were used to investigate the associations between gestational exposures to PM2.5 total mass and its components.<\/p>\n<p><strong>Results<\/strong> \u2014 2,193,427 mother-infant pairs were identified, of which 3907 were diagnosed with CP during the follow-up period. Increased risk of CP was found for SO42\u2212 exposure during early pregnancy in both residual-adjusted (HR: 1.052, 95 % CI: 1.009\u20131.097, per IQR = 0.94 \u03bcg\/m3), and non-adjusted models (HR: 1.050, 95 % CI: 1.007\u20131.095, per IQR = 0.94 \u03bcg\/m3). The concentration-response relationship between the sensitive window found for SO42\u2212 and CP risk (weeks 4\u20139 of gestation) showcased a supralinear pattern.<\/p>\n<p><strong>Conclusions<\/strong> \u2014 Prenatal exposure to SO42\u2212 may be associated with increased CP risk during the early pregnancy period. Associations between prenatal PM2.5 total mass and composition exposure and CP risk should be further investigated.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 Existing literature suggests an association between prenatal exposure to fine particulate air pollution (PM2.5) and cerebral palsy (CP). However, the impact of individual PM2.5 components (SO42\u2212, NH4+, NO3\u2212, SS, BC, dust, OM) on CP risk remains unknown. Objective \u2014 To examine the associations between prenatal exposure to PM2.5 components, and risk of CP [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[41,53,26,35],"migration-helper-qa-sample-set":[],"class_list":["post-22043","journal_article","type-journal_article","status-publish","hentry","topic-brain-diseases","topic-environmental-health","topic-maternity-and-neonatal-care","topic-public-health"],"acf":{"citation":"Ahmed A, Hawken S, Gunz A, Talarico R, Yu C, Messerlian C, Zhang Y, Chen H, Weichenthal S, van Donkelaar A, Martin RV, Lavigne \u00c9. <em>Environ Pollut<\/em>. 2025; 375:126302. Epub 2025 Apr 23.","source_url":"https:\/\/doi.org\/10.1016\/j.envpol.2025.126302","ices_scientist":[1260,21984,1190,16884],"site":[6734],"research_program":[6745],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Prenatal exposure to fine particulate matter composition and risk of cerebral palsy: a population-based retrospective cohort study in Ontario, Canada<\/title>\n<meta name=\"description\" content=\"Background \u2014 Existing literature suggests an association between prenatal exposure to fine particulate air pollution (PM2.5) and cerebral palsy (CP).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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