While testicular germ cell tumors (TGCT) are highly curable, survivors experience toxicities. Pulmonary outcomes post-TGCT are not well understood, particularly among children, adolescents, and young adults (CAYA). Using provincial cancer registries, we identified all CAYA (aged 11\u201321\u2009years) diagnosed with a TGCT from 1992 to 2021 in Ontario, Canada, and matched them (1:5) to general population males (controls). We linked CAYA to health administrative databases to identify pulmonary disease and pulmonary disease healthcare visits (PDV) and classified PDV severity as low (outpatient family physician\/pediatrician), medium (outpatient respirologist\/internist), or high (hospitalization\/emergency department). We assessed acute (<5\u2009years from diagnosis) and late (\u22655\u2009years after diagnosis) toxicities using the cumulative incidence function and cause-specific hazard models. We identified 748 patients (404 chemotherapy-treated) and 3740 controls. Patients’ median age at diagnosis was 19.0\u2009years [interquartile range (IQR):18.0\u201321.0] and 29.7\u2009years (IQR:25.0\u201337.6) at end of follow-up. Non-chemotherapy-treated patients had higher risk of acute toxicities (obstructive lung disease, medium severity PDV, hospitalizations) but similar risk of late toxicities to controls. Chemotherapy-treated patients had higher risk than controls of most acute pulmonary toxicities (except asthma and low severity PDV) and several late toxicities: asthma [hazard ratio (HR)\u2009=\u20092.0, 95%CI:1.1\u20133.8], pulmonary embolism\/infarction (HR\u2009=\u20097.3, 95%CI:1.2\u201344.3), medium severity PDV (HR\u2009=\u20093.9, 95%CI:2.1\u20137.3), and high severity PDV (HR\u2009=\u20091.7, 95%CI:1.0\u20132.8), particularly hospitalizations (HR\u2009=\u20094.1, 95%CI:1.7\u20139.5). CAYA TGCT survivors treated with chemotherapy are at risk for late asthma, pulmonary embolism, pulmonary fibrosis, and specialist and hospital-based pulmonary care. Further follow-up is needed to characterize late pulmonary outcomes as survivors age.<\/p>\n","protected":false},"excerpt":{"rendered":"
While testicular germ cell tumors (TGCT) are highly curable, survivors experience toxicities. Pulmonary outcomes post-TGCT are not well understood, particularly among children, adolescents, and young adults (CAYA). Using provincial cancer registries, we identified all CAYA (aged 11\u201321\u2009years) diagnosed with a TGCT from 1992 to 2021 in Ontario, Canada, and matched them (1:5) to general population […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[38],"migration-helper-qa-sample-set":[],"class_list":["post-22018","journal_article","type-journal_article","status-publish","hentry","topic-cancer-and-cancer-screening"],"acf":{"citation":"Ajaj R, Gershon AS, Lau C, Gupta S, Baxter NN, Sutradhar R, Pole JD, Shaikh F, Nathan PC. Int J Cancer<\/em>. 2025; Jun 24 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.1002\/ijc.70017","ices_scientist":[1244,1239,1177,1370,1098,1302],"site":[6733],"research_program":[6741],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"\n