{"id":21924,"date":"2025-06-06T16:34:43","date_gmt":"2025-06-06T20:34:43","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=21924"},"modified":"2025-06-10T16:51:38","modified_gmt":"2025-06-10T20:51:38","slug":"prematurity-at-birth-and-risk-of-self-injury-overdose-or-death-in-adolescence-and-early-adulthood","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/prematurity-at-birth-and-risk-of-self-injury-overdose-or-death-in-adolescence-and-early-adulthood\/","title":{"rendered":"Prematurity at birth and risk of self-injury, overdose or death in adolescence and early adulthood: a population-based cohort study"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 Preterm birth may adversely affect cortical brain development, and subsequent cognition in childhood and adolescence. Such abnormalities in brain development are correlated with suicidal and non-suicidal self-injury and persistent substance use, and to unintentional injury as well.<\/p>\n<p><strong>Objective<\/strong> \u2014 To evaluate the risk of self-injury, overdose, and all-cause mortality among adolescents and young adults \u2013 each in relation to preterm birth.<\/p>\n<p><strong>Design<\/strong> \u2014 Population-based cohort study in Ontario, Canada, where there is universal healthcare for all.<\/p>\n<p><strong>Setting<\/strong> \u2014 All of Ontario, Canada, where there is universal healthcare.<\/p>\n<p><strong>Participants<\/strong> \u2014 All youths born in Ontario from 1992 to 2012, and alive at age 10 years.<\/p>\n<p><strong>Exposures<\/strong> \u2014 Degree of prematurity in 2-week earlier increments, as well as preterm birth &lt;\u202f37 weeks\u2019 gestation.<\/p>\n<p><strong>Outcomes<\/strong> \u2014 i) Primary composite of an ED visit or hospitalization for intentional self-injury, poisoning or overdose, or all-cause mortality; and ii) co-primary composite of intentional self-injury, poisoning or overdose \u2013 each assessed between ages 10\u201324 years.<\/p>\n<p><strong>Results<\/strong> \u2014 Among 2352,563 youths in the cohort, 151,182 (6.4\u202f%) were born preterm. Adjusted hazard ratios (aHR) for i) self-injury, overdose, or all-cause mortality was 1.03 (95\u202f% CI 1.01\u20131.05) per 2-week earlier gestational age at birth; and ii) 1.01 (95\u202f% CI 0.99\u20131.03) for self-injury or overdose. Compared to term births, preterm birth &lt;\u202f37 weeks\u2019 gestation was associated with a higher aHR for i) self-injury, overdose or all-cause mortality (1.09, 95\u202f% CI 1.05\u20131.12); and ii) self-injury or overdose (1.06, 95\u202f% CI 1.02\u20131.10).<\/p>\n<p><strong>Conclusion<\/strong> \u2014 Preterm birth may be associated with a slightly higher risk of all-cause mortality and, possibly, self-injury and overdose among adolescents and young adults. Ongoing efforts might focus on the health of youths who were born prematurely as they enter their adolescent years.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 Preterm birth may adversely affect cortical brain development, and subsequent cognition in childhood and adolescence. Such abnormalities in brain development are correlated with suicidal and non-suicidal self-injury and persistent substance use, and to unintentional injury as well. Objective \u2014 To evaluate the risk of self-injury, overdose, and all-cause mortality among adolescents and young [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[16,34,35],"migration-helper-qa-sample-set":[],"class_list":["post-21924","journal_article","type-journal_article","status-publish","hentry","topic-children-and-young-people","topic-mental-health-and-addictions","topic-public-health"],"acf":{"citation":"Ray JG, Pirouzmand N, Park AL, Austin PC, Vigod S, Grandi S, Berger H, Cohen E. <em>Ann Epidemiol<\/em>. 2025; S1047-2797(25):00117-6. Epub 2025 Jun 6.","source_url":"https:\/\/doi.org\/10.1016\/j.annepidem.2025.06.002","ices_scientist":[1338,1385,1116,1236,1199],"site":[6733],"research_program":[6740],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Prematurity at birth and risk of self-injury, overdose or death in adolescence and early adulthood: a population-based cohort study<\/title>\n<meta name=\"description\" content=\"Background \u2014 Preterm birth may adversely affect cortical brain development, and subsequent cognition in childhood and adolescence. 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