{"id":2135,"date":"2021-12-21T00:00:00","date_gmt":"2021-12-21T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/the-association-of-statin-subgroups-with-lower-urinary-tract-symptoms-following-a-prostate-biopsy\/"},"modified":"2023-06-14T19:33:31","modified_gmt":"2023-06-14T23:33:31","slug":"the-association-of-statin-subgroups-with-lower-urinary-tract-symptoms-following-a-prostate-biopsy","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/the-association-of-statin-subgroups-with-lower-urinary-tract-symptoms-following-a-prostate-biopsy\/","title":{"rendered":"The association of statin subgroups with lower urinary tract symptoms following a prostate biopsy"},"content":{"rendered":"<p><strong>Introduction <\/strong>&#x2014; This was a secondary analysis aiming to assess whether hydrophilic or hydrophobic statins have a differential effect on urinary retention (UR) and lower urinary tract symptoms (LUTS) in men following a prostate biopsy (PB), who were at risk for prostate cancer development.<\/p>\n<p><strong>Methods<\/strong> &#x2014; This was a population-based cohort study with data incorporated from the Institute for Clinical and Evaluative Sciences database to identify all Ontarian men aged 66 and above with a history of a single negative PB between 1994 and 2016, with no drug prescription history of any of several putative chemopreventative medications (statins, proton pump inhibitors, five-alpha-reductase inhibitors, and alpha-blockers). Multivariable Cox regression models with time-dependent covariates were used to assess the association of hydrophilic and hydrophobic statins with UR and LUTS within 30 days of a PB. All models were adjusted for other known putative chemopreventive medications, age, rurality, pharmacologically treated diabetes, comorbidity score, and study inclusion year.<\/p>\n<p><strong>Results <\/strong>&#x2014; Overall, 21 512 men were included, with a median followup time of 9.4 years (interquartile range [IQR] 5.4-13.4 years). Hydrophobic and hydrophilic statins were initiated by 30.7% and 19.6% of men, respectively, after the first negative PB. UR and LUTS were experienced by 2.2% and 10% of men, respectively. Cox models demonstrated hydrophilic statins were associated with a lower risk of UR (hazard ratio [HR] 0.56, 95% confidence interval [CI] 0.38-0.83, p=0.0038) and LUTS (HR 0.86, 95% CI 0.76-0.98, p=0.022), while no such association was shown for hydrophobic statins.<\/p>\n<p><strong>Conclusions <\/strong>&#x2014; Initiation of hydrophilic statins in men older than 66 appears to be inversely associated with the risk of UR and LUTS within 30 days of a PB.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Introduction &#x2014; This was a secondary analysis aiming to assess whether hydrophilic or hydrophobic statins have a differential effect on urinary retention (UR) and lower urinary tract symptoms (LUTS) in men following a prostate biopsy (PB), who were at risk for prostate cancer development. Methods &#x2014; This was a population-based cohort study with data incorporated [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-2135","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Goldberg H, Mohsin FK, Chandrasekar T, Wallis CJD, Klaassen Z, Ahmad AE, Saskin R, Kenk M, Saarela O, Kulkarni GS, Alibhai SMH, Fleshner N. <em>Can Urol Assoc J<\/em>. 2022; 16(5):E248-55. Epub 2021 Dec 21.","source_url":"https:\/\/cuaj.ca\/index.php\/journal\/article\/view\/7464","ices_scientist":[1147,1360],"site":[6733],"research_program":[6741],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"733B63A6-EEDB-4B28-B7AA-465BAF6D6AB4","sitecore_item_name":"The-association-of-statin-subgroups-with-lower-urinary-tract-symptoms-following-a-prostate-biopsy","sitecore_field_values":"{\n  \"Title\": \"The association of statin subgroups with lower urinary tract symptoms following a prostate biopsy\",\n  \"Short title\": \"The association of statin subgroups with\",\n  \"Summary\": \"This was an analysis aiming to assess whether hydrophilic or hydrophobic statins have a differential effect on urinary retention and lower urinary tract symptoms in men following a prostate biopsy.\",\n  \"Citation\": \"<p>Goldberg H, Mohsin FK, Chandrasekar T, Wallis CJD, Klaassen Z, Ahmad AE, Saskin R, Kenk M, Saarela O, Kulkarni GS, Alibhai SMH, Fleshner N. <em>Can Urol Assoc J<\/em>. 2022; 16(5):E248-55. Epub 2021 Dec 21. DOI: <a href=\"https:\/\/dx.doi.org\/10.5489\/cuaj.7464\" title=\"opens external link\">https:\/\/dx.doi.org\/10.5489\/cuaj.7464<\/a><\/p>\",\n  \"Abstract\": \"<p><strong>Introduction <\/strong>&mdash; This was a secondary analysis aiming to assess whether hydrophilic or hydrophobic statins have a differential effect on urinary retention (UR) and lower urinary tract symptoms (LUTS) in men following a prostate biopsy (PB), who were at risk for prostate cancer development.<\/p>n<p><strong>Methods<\/strong> &mdash; This was a population-based cohort study with data incorporated from the Institute for Clinical and Evaluative Sciences database to identify all Ontarian men aged 66 and above with a history of a single negative PB between 1994 and 2016, with no drug prescription history of any of several putative chemopreventative medications (statins, proton pump inhibitors, five-alpha-reductase inhibitors, and alpha-blockers). Multivariable Cox regression models with time-dependent covariates were used to assess the association of hydrophilic and hydrophobic statins with UR and LUTS within 30 days of a PB. All models were adjusted for other known putative chemopreventive medications, age, rurality, pharmacologically treated diabetes, comorbidity score, and study inclusion year.<\/p>n<p><strong>Results <\/strong>&mdash; Overall, 21 512 men were included, with a median followup time of 9.4 years (interquartile range [IQR] 5.4-13.4 years). Hydrophobic and hydrophilic statins were initiated by 30.7% and 19.6% of men, respectively, after the first negative PB. UR and LUTS were experienced by 2.2% and 10% of men, respectively. Cox models demonstrated hydrophilic statins were associated with a lower risk of UR (hazard ratio [HR] 0.56, 95% confidence interval [CI] 0.38-0.83, p=0.0038) and LUTS (HR 0.86, 95% CI 0.76-0.98, p=0.022), while no such association was shown for hydrophobic statins.<\/p>n<p><strong>Conclusions <\/strong>&mdash; Initiation of hydrophilic statins in men older than 66 appears to be inversely associated with the risk of UR and LUTS within 30 days of a PB.<\/p>n<p><a href=\"https:\/\/cuaj.ca\/index.php\/journal\/article\/view\/7464\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Research Programs\": \"{85DE96A6-4C96-40C7-8E6D-7597A0EB5F80}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n  \"ICES Scientists\": \"{9564D1CB-B35F-4CEC-9144-23097BB45807}|{826B4C0C-81D4-49A9-837F-DB6413A32E7C}\",\n  \"Posted Date\": \"20211221T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2021\/December\/The-association-of-statin-subgroups-with-lower-urinary-tract-symptoms-following-a-prostate-biopsy"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | The association of statin subgroups with lower urinary tract symptoms following a prostate biopsy<\/title>\n<meta name=\"description\" content=\"Introduction &#x2014; 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