{"id":2133,"date":"2021-12-29T00:00:00","date_gmt":"2021-12-29T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/incidence-and-outcomes-associated-with-clostridioides-difficile-infection-in-solid-organ-transplant-recipients\/"},"modified":"2023-06-14T19:32:42","modified_gmt":"2023-06-14T23:32:42","slug":"incidence-and-outcomes-associated-with-clostridioides-difficile-infection-in-solid-organ-transplant-recipients","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/incidence-and-outcomes-associated-with-clostridioides-difficile-infection-in-solid-organ-transplant-recipients\/","title":{"rendered":"Incidence and outcomes associated with Clostridioides difficile infection in solid organ transplant recipients"},"content":{"rendered":"<p><strong>Importance<\/strong> &#x2014; Little is known about the incidence and outcomes of <em>Clostridioides difficile<\/em> infection (CDI) in solid organ transplant (SOT) recipients.<\/p>\n<p><strong>Objective<\/strong> &#x2014; To estimate the CDI incidence and outcomes in SOT recipients.<\/p>\n<p><span class=\"bold\">Design, Setting, and Participants<\/span> &#x2014; A population-based cohort study was conducted using administrative healthcare data for all Ontario, Canada, residents who received organ allografts from April 1, 2003, to December 31, 2017; March 31, 2020, was the end of the study period.<\/p>\n<p><span class=\"bold\">Main Outcomes and Measures<\/span> &#x2014; The primary outcome was hospital admission with CDI diagnosis. The secondary outcomes included all-cause death, intensive care unit admission, acute kidney injury requiring dialysis, and fulminant CDI comprising any of the following: toxic megacolon, ileus, perforation, or colectomy. The association between short- vs long-term mortality (ie, death occurring within or after 90 days post-CDI) and the following variables was evaluated: age, sex, Deyo-Charlson Comorbidity Index, SOT type, early- vs late-onset CDI, fulminant CDI, intensive care unit admission, and acute kidney injury requiring acute dialysis.<\/p>\n<p><strong>Results<\/strong> &#x2014; Overall, 10 724 SOT recipients (6901 [64.4%] men; median age, 54 [IQR, 44-62] years) were eligible. Kidney transplant was the most common SOT type (6453 [60.2%]). The median follow-up time was 5.0 (IQR, 2.3-8.8) years, resulting in 61 987 person-years of follow-up. A total of 726 patients (6.8%) were hospitalized with CDI. The 1-year CDI incidence significantly increased in annual cohorts (ie, from 23.1; 95% CI, 12.8-41.8 per 1000 person-years in 2004 to 46.7; 95% CI, 35.0-62.3 per 1000 person-years in 2017; <em>P<\/em> = .001). <em>Clostridioides difficile<\/em> was associated with a 16.8% rate (n = 122) of 90-day mortality. In patients who underwent kidney transplant, CDI was typically late-onset (median interval, 2.2; IQR, 0.4-6.0 years) compared with recipients of other organs. Acute kidney injury requiring dialysis was significantly associated with short-term (adjusted odds ratio [aOR], 1.86; 95% CI, 1.07-3.26) and long-term (adjusted hazard ratio [aHR], 1.89; 95% CI, 1.29-2.78) mortality, and late-onset CDI was also significantly associated with a greater risk of short-term (aOR, 4.26; 95% CI, 2.51-7.22) and long-term (aHR, 2.49; 95% CI, 1.78-3.49) mortality.<\/p>\n<p><span class=\"bold\">Conclusions and Relevance<\/span> &#x2014; In this study, increasing CDI trends in annual cohorts of SOT recipients were observed. Posttransplant CDI was associated with mortality, and late-onset CDI was associated with a greater risk of death than early-onset CDI. These findings suggest that preventive strategies should not be limited to the initial months following transplantation. Comprehensive therapeutic approaches targeting acute kidney injury risk factors in SOT recipients may reduce short- and long-term post-CDI mortality.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Importance &#x2014; Little is known about the incidence and outcomes of Clostridioides difficile infection (CDI) in solid organ transplant (SOT) recipients. Objective &#x2014; To estimate the CDI incidence and outcomes in SOT recipients. Design, Setting, and Participants &#x2014; A population-based cohort study was conducted using administrative healthcare data for all Ontario, Canada, residents who received [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-2133","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Hosseini-Moghaddam SM, Luo B, Bota SE, Husain S, Silverman MS, Daneman N, Brown KA, Paterson JM. <em>JAMA Netw Open<\/em>. 2021; 4(12):e2141089. Epub 2021 Dec 29.","source_url":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2787588","ices_scientist":[1100,1215,1181,1259],"site":[6739],"research_program":[6743],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"1FA81731-C7AD-4347-A5C9-428AD7ABD391","sitecore_item_name":"Incidence-and-outcomes-associated-with-Clostridioides-difficile-infection-in-solid-organ-transplant","sitecore_field_values":"{\n  \"Title\": \"Incidence and outcomes associated with Clostridioides difficile infection in solid organ transplant recipients\",\n  \"Short title\": \"Incidence and outcomes associated with\",\n  \"Summary\": \"The study aimed to estimate the Clostridioides difficile infection incidence and outcomes in solid organ transplant recipients.\",\n  \"Citation\": \"<p>Hosseini-Moghaddam SM, Luo B, Bota SE, Husain S, Silverman MS, Daneman N, Brown KA, Paterson JM. <em>JAMA Netw Open<\/em>. 2021; 4(12):e2141089. Epub 2021 Dec 29. DOI: <a href=\"https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.41089\" title=\"opens external link\">https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.41089<\/a><\/p>\",\n  \"Abstract\": \"<p><strong>Importance<\/strong> &mdash; Little is known about the incidence and outcomes of <em>Clostridioides difficile<\/em> infection (CDI) in solid organ transplant (SOT) recipients.<\/p>n<p><strong>Objective<\/strong> &mdash; To estimate the CDI incidence and outcomes in SOT recipients.<\/p>n<p><span class=\"bold\">Design, Setting, and Participants<\/span> &mdash; A population-based cohort study was conducted using administrative healthcare data for all Ontario, Canada, residents who received organ allografts from April 1, 2003, to December 31, 2017; March 31, 2020, was the end of the study period.<\/p>n<p><span class=\"bold\">Main Outcomes and Measures<\/span> &mdash; The primary outcome was hospital admission with CDI diagnosis. The secondary outcomes included all-cause death, intensive care unit admission, acute kidney injury requiring dialysis, and fulminant CDI comprising any of the following: toxic megacolon, ileus, perforation, or colectomy. The association between short- vs long-term mortality (ie, death occurring within or after 90 days post-CDI) and the following variables was evaluated: age, sex, Deyo-Charlson Comorbidity Index, SOT type, early- vs late-onset CDI, fulminant CDI, intensive care unit admission, and acute kidney injury requiring acute dialysis.<\/p>n<p><strong>Results<\/strong> &mdash; Overall, 10 724 SOT recipients (6901 [64.4%] men; median age, 54 [IQR, 44-62] years) were eligible. Kidney transplant was the most common SOT type (6453 [60.2%]). The median follow-up time was 5.0 (IQR, 2.3-8.8) years, resulting in 61 987 person-years of follow-up. A total of 726 patients (6.8%) were hospitalized with CDI. The 1-year CDI incidence significantly increased in annual cohorts (ie, from 23.1; 95% CI, 12.8-41.8 per 1000 person-years in 2004 to 46.7; 95% CI, 35.0-62.3 per 1000 person-years in 2017; <em>P<\/em> = .001). <em>Clostridioides difficile<\/em> was associated with a 16.8% rate (n = 122) of 90-day mortality. In patients who underwent kidney transplant, CDI was typically late-onset (median interval, 2.2; IQR, 0.4-6.0 years) compared with recipients of other organs. Acute kidney injury requiring dialysis was significantly associated with short-term (adjusted odds ratio [aOR], 1.86; 95% CI, 1.07-3.26) and long-term (adjusted hazard ratio [aHR], 1.89; 95% CI, 1.29-2.78) mortality, and late-onset CDI was also significantly associated with a greater risk of short-term (aOR, 4.26; 95% CI, 2.51-7.22) and long-term (aHR, 2.49; 95% CI, 1.78-3.49) mortality.<\/p>n<p><span class=\"bold\">Conclusions and Relevance<\/span> &mdash; In this study, increasing CDI trends in annual cohorts of SOT recipients were observed. Posttransplant CDI was associated with mortality, and late-onset CDI was associated with a greater risk of death than early-onset CDI. These findings suggest that preventive strategies should not be limited to the initial months following transplantation. Comprehensive therapeutic approaches targeting acute kidney injury risk factors in SOT recipients may reduce short- and long-term post-CDI mortality.<\/p>n<p><a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2787588\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Research Programs\": \"{92CC48EB-79AA-49F6-8A80-16D185170261}\",\n  \"ICES Locations\": \"{3B4AF7E8-6835-410B-AEB8-360A79CA0ED8}\",\n  \"ICES Scientists\": \"{4A1034A0-5248-46A2-805E-20FBC57B1237}|{AB44D37A-7B8D-4D5E-80E9-092E8FC19B8E}|{49600D34-E937-4577-AEE0-21FD95500AA4}|{0B617331-32A4-4D9D-B5B4-F6BC7C1DCDA7}\",\n  \"Posted Date\": \"20211229T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2021\/December\/Incidence-and-outcomes-associated-with-Clostridioides-difficile-infection-in-solid-organ-transplant"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Incidence and outcomes associated with Clostridioides difficile infection in solid organ transplant recipients<\/title>\n<meta name=\"description\" content=\"Importance &#x2014; 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