{"id":2132,"date":"2021-12-30T00:00:00","date_gmt":"2021-12-30T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/long-term-outcomes-of-adults-with-tricuspid-regurgitation-following-transcatheter-atrial-septal-defect-closure\/"},"modified":"2023-06-14T19:33:55","modified_gmt":"2023-06-14T23:33:55","slug":"long-term-outcomes-of-adults-with-tricuspid-regurgitation-following-transcatheter-atrial-septal-defect-closure","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/long-term-outcomes-of-adults-with-tricuspid-regurgitation-following-transcatheter-atrial-septal-defect-closure\/","title":{"rendered":"Long-term outcomes of adults with tricuspid regurgitation following transcatheter atrial septal defect closure"},"content":{"rendered":"<p><strong>Background<\/strong> &#x2014; Functional tricuspid regurgitation (TR) is a common pathophysiological condition in adults with secundum atrial septal defect (ASD). The aim of this study was to evaluate long-term outcomes following transcatheter ASD closure, which have not been well studied among patients with significant TR.<\/p>\n<p><strong>Methods<\/strong> &#x2014; We reviewed consecutive adult patients who underwent transcatheter ASD closure at Toronto General Hospital, Ontario, Canada, between 1998 and 2016. We linked our hospital registry with Ontario population-based health administrative databases to collect longitudinal data on inpatient and outpatient healthcare utilization and vital status.<\/p>\n<p><strong>Results<\/strong> &#x2014; In this cohort study of 949 patients, 199 (22%) patients had moderate to severe TR prior to transcatheter ASD closure. A significant proportion of patients (61%) showed improvement in TR severity to at least mild TR following ASD intervention. At a median follow-up of 10.9 years, patients with baseline mild or no TR, compared to those with greater than moderate TR, had significantly lower rates of all-cause mortality (6.8 vs 22.5 per 1000 person years (PY), p=&lt;0.001), composite hospitalization for atrial fibrillation (AF) or heart failure (HF) (22.3 vs 49.1 per 1000 PY, p&lt;0.001), and new onset of AF (10.4 vs 20.2 per 1000 PY, p=0.002), and HF (5.0 vs 9.2 per 1000 PY, p=0.039). Pre-procedural TR was independently associated with higher all-cause mortality (adjusted hazards ratio; HR=1.69, 95% confidence interval: 1.08-2.62).<\/p>\n<p><strong>Conclusions<\/strong> &#x2014; TR severity was independently associated with a higher risk of mortality and morbidity. Further investigation of earlier device closure or concomitant tricuspid valve intervention may be of interest.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background &#x2014; Functional tricuspid regurgitation (TR) is a common pathophysiological condition in adults with secundum atrial septal defect (ASD). The aim of this study was to evaluate long-term outcomes following transcatheter ASD closure, which have not been well studied among patients with significant TR. Methods &#x2014; We reviewed consecutive adult patients who underwent transcatheter ASD [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-2132","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Bach Y, Abrahamyan L, Lee DS, Dharma C, Day J, Parker JD, Benson L, Osten M, Horlick E. <em>Can J Cardiol<\/em>. 2022; 38(3):330-7. Epub 2021 Dec 30.","source_url":"https:\/\/doi.org\/10.1016\/j.cjca.2021.12.012","ices_scientist":[1290,17632],"site":[6733],"research_program":[6742],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"EBF16D3C-2CBE-4324-A85D-4886701C5F0D","sitecore_item_name":"Long-term-outcomes-of-adults-with-tricuspid-regurgitation-following-transcatheter-atrial-septal","sitecore_field_values":"{\n  \"Title\": \"Long-term outcomes of adults with tricuspid regurgitation following transcatheter atrial septal defect closure\",\n  \"Short title\": \"Long-term outcomes of adults with\",\n  \"Summary\": \"This study found tricuspid regurgitation severity was independently associated with a higher risk of mortality and morbidity. \",\n  \"Citation\": \"<p>Bach Y, Abrahamyan L, Lee DS, Dharma C, Day J, Parker JD, Benson L, Osten M, Horlick E. <em>Can J Cardiol<\/em>. 2022; 38(3):330-7. Epub 2021 Dec 30. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.cjca.2021.12.012\" title=\"opens external link\">https:\/\/doi.org\/10.1016\/j.cjca.2021.12.012<\/a><\/p>\",\n  \"Abstract\": \"<p><strong>Background<\/strong> &mdash; Functional tricuspid regurgitation (TR) is a common pathophysiological condition in adults with secundum atrial septal defect (ASD). The aim of this study was to evaluate long-term outcomes following transcatheter ASD closure, which have not been well studied among patients with significant TR.<\/p>n<p><strong>Methods<\/strong> &mdash; We reviewed consecutive adult patients who underwent transcatheter ASD closure at Toronto General Hospital, Ontario, Canada, between 1998 and 2016. We linked our hospital registry with Ontario population-based health administrative databases to collect longitudinal data on inpatient and outpatient healthcare utilization and vital status.<\/p>n<p><strong>Results<\/strong> &mdash; In this cohort study of 949 patients, 199 (22%) patients had moderate to severe TR prior to transcatheter ASD closure. A significant proportion of patients (61%) showed improvement in TR severity to at least mild TR following ASD intervention. At a median follow-up of 10.9 years, patients with baseline mild or no TR, compared to those with greater than moderate TR, had significantly lower rates of all-cause mortality (6.8 vs 22.5 per 1000 person years (PY), p=&lt;0.001), composite hospitalization for atrial fibrillation (AF) or heart failure (HF) (22.3 vs 49.1 per 1000 PY, p&lt;0.001), and new onset of AF (10.4 vs 20.2 per 1000 PY, p=0.002), and HF (5.0 vs 9.2 per 1000 PY, p=0.039). Pre-procedural TR was independently associated with higher all-cause mortality (adjusted hazards ratio; HR=1.69, 95% confidence interval: 1.08-2.62).<\/p>n<p><strong>Conclusions<\/strong> &mdash; TR severity was independently associated with a higher risk of mortality and morbidity. Further investigation of earlier device closure or concomitant tricuspid valve intervention may be of interest.<\/p>\",\n  \"Research Programs\": \"{BEC72DE0-BA8C-42B8-ACE5-EE29FFB2CB3B}\",\n  \"ICES Locations\": \"{4FCAABBA-14A5-42E6-8F33-BC6C2F1D9908}\",\n  \"ICES Scientists\": \"{CEEE13AD-C7DE-455F-ACF8-AAD7D27BB178}\",\n  \"Posted Date\": \"20211230T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2021\/December\/Long-term-outcomes-of-adults-with-tricuspid-regurgitation-following-transcatheter-atrial-septal"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Long-term outcomes of adults with tricuspid regurgitation following transcatheter atrial septal defect closure<\/title>\n<meta name=\"description\" content=\"Background &#x2014; Functional tricuspid regurgitation (TR) is a common pathophysiological condition in adults with secundum atrial septal defect (ASD).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/long-term-outcomes-of-adults-with-tricuspid-regurgitation-following-transcatheter-atrial-septal-defect-closure\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Long-term outcomes of adults with tricuspid regurgitation following transcatheter atrial septal defect closure\" \/>\n<meta property=\"og:description\" content=\"Background &#x2014; 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