{"id":21277,"date":"2025-02-19T10:01:09","date_gmt":"2025-02-19T15:01:09","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=21277"},"modified":"2025-02-27T10:03:56","modified_gmt":"2025-02-27T15:03:56","slug":"end-of-life-care-in-glioblastoma","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/end-of-life-care-in-glioblastoma\/","title":{"rendered":"End-of-life care in glioblastoma: a population-based study"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 The end-of-life (EoL) phase of care is inevitable for glioblastoma (GBM) patients; however, it lacks standardization. This study aimed to characterize the utilization of care at EoL in GBM patients, focusing on trends over time, regional variability, and the influence of socioeconomic factors.<\/p>\n<p><strong>Methods<\/strong> \u2014 This was a retrospective population-based cohort study of all patients with GBM treated in Ontario between 1994 \u2013 2018 using administrative health data and registries available at ICES (formerly the Institute for Clinical Evaluative Sciences). The proportion of patients with palliative care, supportive care, and in-hospital deaths by year of diagnosis was estimated, and trends assessed with the Cochrane-Armitage trend test.<\/p>\n<p><strong>Results<\/strong> \u2014 The cohort included 9,013 GBM patients. There was an increase in supportive care components over the study time-period (29.6% in 1994 \u2013 1998 to 60.2% in 2014 \u2013 2018; p &lt; 0.0001). There was a simultaneous decrease in in-hospital deaths (50.5% in 1994 \u2013 1998 to 21.4% in 2014 \u2013 2018; p&lt;0.001) and hospitalizations within 30 days before death (65.5% in 1994-1998 to 51.7% in 2014 \u2013 2018, p&lt;0.001). This coincided with an increased in chemotherapy administration within 14 days of death and ICU admissions within 30 days of death over the studied period of time. Patient neighborhood income level and geographic location influenced EoL care patterns with regards to both supportive and aggressive components.<\/p>\n<p><strong>Conclusions<\/strong> \u2014 Over time there was an expansion of both inpatient and outpatient palliative care use at EoL. Rurality and neighborhood income quintile significantly influenced the utilization of these resources, underscoring the need for standardized EoL care practices.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 The end-of-life (EoL) phase of care is inevitable for glioblastoma (GBM) patients; however, it lacks standardization. This study aimed to characterize the utilization of care at EoL in GBM patients, focusing on trends over time, regional variability, and the influence of socioeconomic factors. Methods \u2014 This was a retrospective population-based cohort study of [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[38,33],"migration-helper-qa-sample-set":[],"class_list":["post-21277","journal_article","type-journal_article","status-publish","hentry","topic-cancer-and-cancer-screening","topic-end-of-life-care"],"acf":{"citation":"Ellenbogen Y, Taslimi S, Shellenberger J, Brogly SB, Zadeh G, Alkins R. <em>Neuro Oncol<\/em>. 2025; Feb 19 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.1093\/neuonc\/noaf043","ices_scientist":[1168],"site":[6736],"research_program":[6740],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | End-of-life care in glioblastoma: a population-based study<\/title>\n<meta name=\"description\" content=\"Background \u2014 The end-of-life (EoL) phase of care is inevitable for glioblastoma (GBM) patients; however, it lacks standardization. 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