{"id":20892,"date":"2024-12-19T09:16:48","date_gmt":"2024-12-19T14:16:48","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=20892"},"modified":"2025-01-08T09:23:36","modified_gmt":"2025-01-08T14:23:36","slug":"initial-effectiveness-of-mrna-1273-against-sars-cov-2-infection-and-hospitalization-in-young-children","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/initial-effectiveness-of-mrna-1273-against-sars-cov-2-infection-and-hospitalization-in-young-children\/","title":{"rendered":"Initial effectiveness of mRNA-1273 against SARS-CoV-2 infection and hospitalization in young children"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 Data on mRNA-1273 (Moderna) vaccine effectiveness (VE) in children aged 6 months to 5 years are limited. The objectives of this study were to assess mRNA-1273 vaccine effectiveness against symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19)\u2013related hospitalization among children aged 6 months to 5 years during the initial 5 months of the vaccination campaign rollout, as well as to determine whether VE varied by age group (6 months to &lt;2 years vs 2 to 5 years).<\/p>\n<p><strong>Methods<\/strong> \u2014 We used a test-negative study with linked health administrative data in Ontario, Canada, to evaluate vaccine effectiveness of mRNA-1273 against symptomatic SARS-CoV-2 infection and COVID-19-related hospitalization from July 28 to December 31, 2022. Participants included symptomatic children aged 6 months to 5 years who were tested by real-time polymerase chain reaction. The primary outcome was symptomatic infection, and the secondary outcome was COVID-19-related hospitalization.<\/p>\n<p><strong>Results<\/strong> \u2014 We included 572 test-positive cases and 3467 test-negative controls. Receipt of mRNA-1273 was associated with reduced symptomatic SARS-CoV-2 infection (VE, 90%; 95% CI, 53%\u201399%) and COVID-19-related hospitalization (VE, 82%; 95% CI, 4%\u201399%) \u22657 days after the second dose. We were unable to detect heterogeneity in VE across age groups.<\/p>\n<p><strong>Conclusions<\/strong> \u2014 Our findings suggest that mRNA-1273 vaccine effectiveness was initially strong against symptomatic SARS-CoV-2 infection and hospitalization in children aged 6 months to 5 years. Further research is needed to understand long-term effectiveness.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 Data on mRNA-1273 (Moderna) vaccine effectiveness (VE) in children aged 6 months to 5 years are limited. The objectives of this study were to assess mRNA-1273 vaccine effectiveness against symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19)\u2013related hospitalization among children aged 6 months to 5 years during [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[16,39,35],"migration-helper-qa-sample-set":[],"class_list":["post-20892","journal_article","type-journal_article","status-publish","hentry","topic-children-and-young-people","topic-infectious-diseases","topic-public-health"],"acf":{"citation":"Aglipay M, Maguire JL, Swayze S, Tuite A, Mamdani M, Keown-Stoneman C, Birken CS, Kwong JC. <em>Open Forum Infect Dis<\/em>. 2024; 12(1):ofae718.","source_url":"https:\/\/doi.org\/10.1093\/ofid\/ofae718","ices_scientist":[1311,1325,1166,1149],"site":[6733],"research_program":[6745],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Initial effectiveness of mRNA-1273 against SARS-CoV-2 infection and hospitalization in young children<\/title>\n<meta name=\"description\" content=\"Background \u2014 Data on mRNA-1273 (Moderna) vaccine effectiveness (VE) in children aged 6 months to 5 years are limited. 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