{"id":20855,"date":"2024-12-27T09:01:24","date_gmt":"2024-12-27T14:01:24","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=20855"},"modified":"2025-01-02T09:06:59","modified_gmt":"2025-01-02T14:06:59","slug":"epidemiology-and-outcomes-of-alcohol-associated-hepatitis-in-adolescents-and-young-adults","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/epidemiology-and-outcomes-of-alcohol-associated-hepatitis-in-adolescents-and-young-adults\/","title":{"rendered":"Epidemiology and outcomes of alcohol-associated hepatitis in adolescents and young adults"},"content":{"rendered":"<p><strong>Importance<\/strong>\u00a0\u2014\u00a0Alcohol-associated hepatitis (AH) has high mortality, and rates are increasing among adolescents and young adults (AYAs).<\/p>\n<p><strong>Objective<\/strong>\u00a0\u2014\u00a0To define the sex-specific epidemiology of AH in AYAs and the association between female sex and liver-related outcomes after a first presentation of AH.<\/p>\n<p><strong>Design, setting, and participants\u00a0<\/strong>\u2014\u00a0A retrospective, population-based cohort study of routinely collected health care data held at ICES from Ontario, Canada, was conducted. Data on AYAs (age, 13-39 years) with first presentation of AH without a history of cirrhosis and\/or decompensation from January 1 to December 31, 2022, were included in the analysis.<\/p>\n<p><strong>Exposures\u00a0<\/strong>\u2014\u00a0Study year and female sex.<\/p>\n<p><strong>Main outcome and measures\u00a0<\/strong>\u2014\u00a0Overall and sex-specific yearly rates of AH were compared using Poisson regression and rate ratios (RRs). Associations between female sex and incident cirrhosis and\/or decompensation were evaluated using competing risks regression, and liver-related mortality by sex was evaluated with cumulative incidence functions.<\/p>\n<p><strong>Results\u00a0<\/strong>\u2014\u00a0A total of 3340 AYAs with AH were identified. Median age was 33 (IQR, 28-36) years, and the population included 1190 (36%) females and 2150 (64%) males. Rates of AH increased by 8% per year (RR, 1.08; 95% CI, 1.07-1.09), with yearly rates increasing faster among females (RR, 1.11; 95% CI, 1.09-1.12) than males (RR, 1.07; 95% CI, 1.06-1.07). A total of 2374 individuals (71%) were alive without cirrhosis 6 months after AH presentation. Of those, 527 (22%) developed incident cirrhosis and\/or decompensation after a median follow-up of 4 (IQR, 2-9) years (37% females vs 29% males; P\u2009&lt;\u2009.001). After adjustment, female sex was associated with a 47% higher subhazard of cirrhosis and\/or decompensation compared with male sex (38%) (subhazard, 1.47; 95% CI, 1.23-1.76; P\u2009&lt;\u2009.001). The cumulative incidence of liver-related mortality at 10 years was higher among females (11.0%; 95% CI, 8.3%-14.2%) than males (6.9%; 95% CI, 5.4%-8.6%) (P\u2009=\u2009.01).<\/p>\n<p><strong>Conclusions and relevance\u00a0<\/strong>\u2014\u00a0Over the past 2 decades, the rates of AH among AYAs increased significantly, with the greatest increase observed among females. The findings of this study suggest sex-specific interventions to prevent the development of AH and the progression to cirrhosis after an episode of AH are needed.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Importance\u00a0\u2014\u00a0Alcohol-associated hepatitis (AH) has high mortality, and rates are increasing among adolescents and young adults (AYAs). Objective\u00a0\u2014\u00a0To define the sex-specific epidemiology of AH in AYAs and the association between female sex and liver-related outcomes after a first presentation of AH. Design, setting, and participants\u00a0\u2014\u00a0A retrospective, population-based cohort study of routinely collected health care data held [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[42,64,34],"migration-helper-qa-sample-set":[],"class_list":["post-20855","journal_article","type-journal_article","status-publish","hentry","topic-chronic-diseases-and-multimorbidity","topic-epidemiology","topic-mental-health-and-addictions"],"acf":{"citation":"Flemming JA, Djerboua M, Chapman O, Ayonrinde O, Terrault NA. <em>JAMA Netw Open<\/em>. 2024; 7(12):e2452459.","source_url":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.52459","ices_scientist":[1228],"site":[6736],"research_program":[6741],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Epidemiology and outcomes of alcohol-associated hepatitis in adolescents and young adults<\/title>\n<meta name=\"description\" content=\"Importance\u00a0\u2014\u00a0Alcohol-associated hepatitis (AH) has high mortality, and rates are increasing among adolescents and young adults (AYAs). 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