{"id":20697,"date":"2024-10-24T15:29:44","date_gmt":"2024-10-24T19:29:44","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&p=20697"},"modified":"2024-11-14T15:43:16","modified_gmt":"2024-11-14T20:43:16","slug":"burden-of-infant-group-b-streptococcus-disease-and-impact-of-maternal-screening-and-antibiotic-prophylaxis-in-ontario-canada","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/burden-of-infant-group-b-streptococcus-disease-and-impact-of-maternal-screening-and-antibiotic-prophylaxis-in-ontario-canada\/","title":{"rendered":"Burden of infant group B\u00a0Streptococcus\u00a0disease and impact of maternal screening and antibiotic prophylaxis in Ontario, Canada: a population-based cohort study"},"content":{"rendered":"

Background<\/strong> \u2014\u00a0Group B Streptococcus (GBS) significantly contributes to neonatal sepsis and meningitis, with varying disease rates reported globally and limited population-based data. We estimated infant GBS disease burden in Ontario, Canada and assessed the association of maternal GBS screening (35\u201337 weeks’ gestation) and intrapartum antibiotic prophylaxis (IAP) provision with infant disease rates.<\/p>\n

Methods<\/strong> \u2014 Our population-based cohort study included pregnant individuals and their offspring from April 2012 to March 2018, utilising the provincial birth registry linked to health administrative data. GBS cases were ascertained through culture results and diagnostic codes. We calculated incidence rates for early-onset disease (EOD: 0\u20136 days), late-onset disease (LOD: 7\u201389 days), and ultra-LOD (ULOD: 90\u2013365 days). Adjusted incidence rate ratios (aIRR) were derived via log-binomial regression to compare infant GBS rates according to screening and IAP-receipt.<\/p>\n

Findings<\/strong> \u2014 Among 776,148 liveborn infants, we identified 803 with GBS, with multiples exhibiting a threefold incidence increase. Incidence rates of EOD, LOD and ULOD were 0.49, 0.46 and 0.07 per 1000 livebirths, respectively. Of eligible pregnancies, 94% were screened; 23% screened positive, and 81% of them received IAP. Nearly 12% of term EOD infants had mothers who missed IAP despite screening positive. Maternal screening was associated with lower rates of any infant GBS disease (aIRR: 0.60; 95% CI: 0.45, 0.80). Among screen-positive births, IAP-receipt was associated with reduced rates of EOD (aIRR: 0.72, 95% CI: 0.48, 1.29) and LOD\/ULOD (aIRR: 0.69; 95% CI: 0.46, 1.05), but confidence intervals included 1.0.<\/p>\n

Interpretation <\/strong>\u2014\u00a0Our study, the largest Canadian investigation into infant GBS disease, highlights both widespread adoption and ongoing challenges of the current prevention strategy.<\/p>\n","protected":false},"excerpt":{"rendered":"

Background \u2014\u00a0Group B Streptococcus (GBS) significantly contributes to neonatal sepsis and meningitis, with varying disease rates reported globally and limited population-based data. We estimated infant GBS disease burden in Ontario, Canada and assessed the association of maternal GBS screening (35\u201337 weeks’ gestation) and intrapartum antibiotic prophylaxis (IAP) provision with infant disease rates. Methods \u2014 Our […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[39,26],"migration-helper-qa-sample-set":[],"class_list":["post-20697","journal_article","type-journal_article","status-publish","hentry","topic-infectious-diseases","topic-maternity-and-neonatal-care"],"acf":{"citation":"Fakhraei R, Fell DB, El-Cha\u00e2r D, Thampi N, Sander B, Brown KA, Crowcroft N, Bolotin S, Barrett J, Darling EK, Fittipaldi N, Lamagni T, McGeer A, Murti M, Sadarangani M, Schwartz KL, Yasseen A, Tunis M, Petrcich W, Wilson K. Lancet Reg Health Am<\/em>. 2024; 39:100914.","source_url":"https:\/\/doi.org\/10.1016\/j.lana.2024.100914","ices_scientist":[1362,1181,1212,1347],"site":[6734],"research_program":[6740],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"\nICES | Burden of infant group B\u00a0Streptococcus\u00a0disease and impact of maternal screening and antibiotic prophylaxis in Ontario, Canada: a population-based cohort study<\/title>\n<meta name=\"description\" content=\"Background \u2014\u00a0Group B Streptococcus (GBS) significantly contributes to neonatal sepsis and meningitis, with varying disease rates reported globally and\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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