{"id":2067,"date":"2022-07-11T00:00:00","date_gmt":"2022-07-11T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/venous-thromboembolism-in-surgically-treated-esophageal-cancer-patients-a-provincial-population-based-study\/"},"modified":"2023-06-14T19:57:18","modified_gmt":"2023-06-14T23:57:18","slug":"venous-thromboembolism-in-surgically-treated-esophageal-cancer-patients-a-provincial-population-based-study","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/venous-thromboembolism-in-surgically-treated-esophageal-cancer-patients-a-provincial-population-based-study\/","title":{"rendered":"Venous thromboembolism in surgically treated esophageal cancer patients: a provincial population-based study"},"content":{"rendered":"<p><strong>Objective<\/strong> &#x2014; Venous thromboembolism (VTE) is a major cause of morbidity and mortality in surgical patients. Surgery for esophageal cancer carries a high risk of VTE. This study identifies the risk factors and associated mortality of thrombotic complications among patients undergoing esophageal cancer surgery.<\/p>\n<p><strong>Methods<\/strong> &#x2014; All patients in the province of Ontario undergoing esophageal cancer surgery from 2007 to 2017 were identified. Logistic regression identified VTE risk factors at 90 days and 1 year postoperatively. A flexible parametric survival analysis compared mortality and survival up to 5 years after surgery for patients with and without a postoperative VTE.<\/p>\n<p><strong>Results<\/strong> &#x2014; Overall 9,876 patients with esophageal cancer were identified; 2,536 (25.7%) underwent surgery. VTE incidence at 90 days and 1 year postoperatively were 4.1 and 6.3%, respectively. Patient factors including age, sex, performance status, and comorbidities were not associated with VTE risk. VTE risk peaked at 1 month after surgery, with a subsequent decline, plateauing after 6 months. Adenocarcinoma was strongly associated with VTE risk compared with squamous cell carcinoma (SCC) (odds ratio [OR] 2.53, 95% confidence interval [CI] 1.38&#x2013;4.63, <em>p<\/em> = 0.003). VTE risk decreased with adjuvant chemotherapy (OR = 0.58, 95% CI 0.36&#x2013;0.94, p = 0.028). Postoperative VTE was associated with decreased survival at 1 and 5 years (hazard ratio = 1.57, 95% CI 1.23&#x2013;2.00, <em>p<\/em> &lt; 0.001).<\/p>\n<p><strong>Conclusion<\/strong> &#x2014; Esophageal cancer patients with postoperative VTE have worse long-term survival compared with those without thrombotic complications. Adenocarcinoma carries a higher VTE risk compared with SCC. Strategies to reduce VTE risk should be considered to reduce the negative impacts on survival conferred by thrombotic events.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Objective &#x2014; Venous thromboembolism (VTE) is a major cause of morbidity and mortality in surgical patients. Surgery for esophageal cancer carries a high risk of VTE. This study identifies the risk factors and associated mortality of thrombotic complications among patients undergoing esophageal cancer surgery. Methods &#x2014; All patients in the province of Ontario undergoing esophageal [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-2067","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Akhtar-Danesh GG, Akhtar-Danesh N, Shargall Y. <em>TH Open<\/em>. 2022; 06(03):e168-76. Epub 2022 Jul 11.","source_url":"https:\/\/www.thieme-connect.com\/products\/ejournals\/html\/10.1055\/s-0042-1750378","ices_scientist":[1380],"site":[6737],"research_program":[6741],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"D8FC2D0E-1079-4DCF-AF93-B13E39AEB7C6","sitecore_item_name":"Venous-thromboembolism-in-surgically-treated-esophageal-cancer-patients","sitecore_field_values":"{\n  \"Title\": \"Venous thromboembolism in surgically treated esophageal cancer patients: a provincial population-based study\",\n  \"Short title\": \"Venous thromboembolism in surgically\",\n  \"Summary\": \"This study identifies the risk factors and associated mortality of thrombotic complications among patients undergoing esophageal cancer surgery.\",\n  \"Citation\": \"<p>Akhtar-Danesh GG, Akhtar-Danesh N, Shargall Y. <em>TH Open<\/em>. 2022; 06(03):e168-76. Epub 2022 Jul 11. DOI: <a href=\"https:\/\/doi.org\/10.1055\/s-0042-1750378\" title=\"opens external link\">https:\/\/doi.org\/10.1055\/s-0042-1750378<\/a><\/p>\",\n  \"Abstract\": \"<p><strong>Objective<\/strong> &mdash; Venous thromboembolism (VTE) is a major cause of morbidity and mortality in surgical patients. Surgery for esophageal cancer carries a high risk of VTE. This study identifies the risk factors and associated mortality of thrombotic complications among patients undergoing esophageal cancer surgery.<\/p>n<p><strong>Methods<\/strong> &mdash; All patients in the province of Ontario undergoing esophageal cancer surgery from 2007 to 2017 were identified. Logistic regression identified VTE risk factors at 90 days and 1 year postoperatively. A flexible parametric survival analysis compared mortality and survival up to 5 years after surgery for patients with and without a postoperative VTE.<\/p>n<p><strong>Results<\/strong> &mdash; Overall 9,876 patients with esophageal cancer were identified; 2,536 (25.7%) underwent surgery. VTE incidence at 90 days and 1 year postoperatively were 4.1 and 6.3%, respectively. Patient factors including age, sex, performance status, and comorbidities were not associated with VTE risk. VTE risk peaked at 1 month after surgery, with a subsequent decline, plateauing after 6 months. Adenocarcinoma was strongly associated with VTE risk compared with squamous cell carcinoma (SCC) (odds ratio [OR] 2.53, 95% confidence interval [CI] 1.38&ndash;4.63, <em>p<\/em> = 0.003). VTE risk decreased with adjuvant chemotherapy (OR = 0.58, 95% CI 0.36&ndash;0.94, p = 0.028). Postoperative VTE was associated with decreased survival at 1 and 5 years (hazard ratio = 1.57, 95% CI 1.23&ndash;2.00, <em>p<\/em> &lt; 0.001).<\/p>n<p><strong>Conclusion<\/strong> &mdash; Esophageal cancer patients with postoperative VTE have worse long-term survival compared with those without thrombotic complications. Adenocarcinoma carries a higher VTE risk compared with SCC. Strategies to reduce VTE risk should be considered to reduce the negative impacts on survival conferred by thrombotic events.<\/p>n<p><a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/html\/10.1055\/s-0042-1750378\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Research Programs\": \"{85DE96A6-4C96-40C7-8E6D-7597A0EB5F80}\",\n  \"ICES Locations\": \"{D88BC40D-6453-47B1-9A95-3AC57728064D}\",\n  \"ICES Scientists\": \"{2AA65EAF-4290-4BCF-A509-ECAAA9CC1493}\",\n  \"Posted Date\": \"20220711T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2022\/July\/Venous-thromboembolism-in-surgically-treated-esophageal-cancer-patients"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Venous thromboembolism in surgically treated esophageal cancer patients: a provincial population-based study<\/title>\n<meta name=\"description\" content=\"Objective &#x2014; Venous thromboembolism (VTE) is a major cause of morbidity and mortality in surgical patients. 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