{"id":20396,"date":"2024-09-04T11:27:34","date_gmt":"2024-09-04T15:27:34","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=20396"},"modified":"2024-09-24T13:38:40","modified_gmt":"2024-09-24T17:38:40","slug":"improving-the-clinical-utility-of-platelet-count-for-cancer-detection-in-primary-care-a-cohort-study-in-england-canada-and-australia","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/improving-the-clinical-utility-of-platelet-count-for-cancer-detection-in-primary-care-a-cohort-study-in-england-canada-and-australia\/","title":{"rendered":"Improving the clinical utility of platelet count for cancer detection in primary care: a cohort study in England, Canada, and Australia"},"content":{"rendered":"<p>The platelet count, a component of the full blood count, has been identified as a useful diagnostic marker for cancer in primary care. The reference range for the platelet count is 150 to 400 or 450 \u00d7 109\/L; this range does not account for natural variation in platelet count by age and sex. This study used three primary care cohorts from England, Canada, and Australia. Patients aged 40 years and over with a full blood count were included and stratified by age (in 10-year bands), sex, (male\/female), and platelet count group. Cancer incidence within one year of the test date was estimated from linked registry data. In all three countries, there was a clear upwards trend in cancer incidence with increasing platelet count for both sexes and at all age groups. Lung and colorectal were the most common sites. These results have important implications for the international application of this work; analysis of local health datasets will be crucial to determining appropriate thresholds. Appropriate upper thresholds will depend on local populations, healthcare needs, and priorities. Further research is needed to assess the likely impact of new recommendations on the healthcare system, on cancer outcomes, and patient benefit.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The platelet count, a component of the full blood count, has been identified as a useful diagnostic marker for cancer in primary care. The reference range for the platelet count is 150 to 400 or 450 \u00d7 109\/L; this range does not account for natural variation in platelet count by age and sex. This study [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[38,28],"migration-helper-qa-sample-set":[],"class_list":["post-20396","journal_article","type-journal_article","status-publish","hentry","topic-cancer-and-cancer-screening","topic-primary-care"],"acf":{"citation":"Mounce LTA, Calitri R, Hamilton W, Rafiq M, Emery JD, Giannakeas V, Kotsopoulos J, Bailey SER. <em>Cancers (Basel)<\/em>. 2024; 16(17):3074.","source_url":"https:\/\/doi.org\/10.3390\/cancers16173074","ices_scientist":[23247],"site":[6735],"research_program":[6741],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":[21085],"video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Improving the clinical utility of platelet count for cancer detection in primary care: a cohort study in England, Canada, and Australia<\/title>\n<meta name=\"description\" content=\"The platelet count, a component of the full blood count, has been identified as a useful diagnostic marker for cancer in primary care. The reference range\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/improving-the-clinical-utility-of-platelet-count-for-cancer-detection-in-primary-care-a-cohort-study-in-england-canada-and-australia\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Improving the clinical utility of platelet count for cancer detection in primary care: a cohort study in England, Canada, and Australia\" \/>\n<meta property=\"og:description\" content=\"The platelet count, a component of the full blood count, has been identified as a useful diagnostic marker for cancer in primary care. 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