{"id":20306,"date":"2024-09-11T18:30:00","date_gmt":"2024-09-11T22:30:00","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=20306"},"modified":"2024-09-11T09:56:41","modified_gmt":"2024-09-11T13:56:41","slug":"effectiveness-of-modified-vaccinia-ankara-bavarian-nordic-vaccine-against-mpox-infection-emulation-of-a-target-trial","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/effectiveness-of-modified-vaccinia-ankara-bavarian-nordic-vaccine-against-mpox-infection-emulation-of-a-target-trial\/","title":{"rendered":"Effectiveness of modified vaccinia Ankara-Bavarian Nordic vaccine against mpox infection: emulation of a target trial"},"content":{"rendered":"<p><strong>Objective<\/strong> \u2014\u00a0To estimate the real world effectiveness of modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine against mpox infection.<\/p>\n<p><strong>Design<\/strong>\u00a0\u2014 Emulation of a target trial.<\/p>\n<p><strong>Setting<\/strong> \u2014 Linked databases in Ontario, Canada.<\/p>\n<p><strong>Participants<\/strong> \u2014 9803 men aged \u226518 years with a history of being tested for syphilis and a laboratory confirmed bacterial sexually transmitted infection (STI) in the previous year, or who filled a prescription for HIV pre-exposure prophylaxis in the previous year. On each day between 12 June 2022 and 27 October 2022, those who had been vaccinated 15 days previously were matched 1:1 with unvaccinated men by age, geographical region, past HIV diagnosis, number of bacterial STI diagnoses in the previous three years, and receipt of any non-MVA-BN vaccine in the previous year.<\/p>\n<p><strong>Main outcome measure<\/strong> \u2014 The main outcome measure was vaccine effectiveness ((1\u2013hazard ratio)\u00d7100) of one dose of subcutaneously administered MVA-BN against laboratory confirmed mpox infection. A Cox proportional hazards model was used to estimate hazard ratios to compare the rate of laboratory confirmed mpox between the two groups.<\/p>\n<p><strong>Results<\/strong> \u2014 3204 men who received the vaccine were matched to 3204 unvaccinated controls. A total of 71 mpox infections were diagnosed, with 0.09 per 1000 person days (95% confidence interval (CI) 0.05 to 0.13) in the vaccinated group and 0.20 per 1000 person days (0.15 to 0.27) in the unvaccinated group over the study period of 153 days. Estimated vaccine effectiveness of one dose of MVA-BN against mpox infection was 58% (95% CI 31% to 75%).<\/p>\n<p><strong>Conclusion<\/strong> \u2014 The findings of this study, conducted in the context of a targeted vaccination programme and evolving outbreak of mpox, suggest that one dose of MVA-BN is moderately effective in preventing mpox infection.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Objective \u2014\u00a0To estimate the real world effectiveness of modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine against mpox infection. Design\u00a0\u2014 Emulation of a target trial. Setting \u2014 Linked databases in Ontario, Canada. Participants \u2014 9803 men aged \u226518 years with a history of being tested for syphilis and a laboratory confirmed bacterial sexually transmitted infection (STI) in [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[39,35],"migration-helper-qa-sample-set":[],"class_list":["post-20306","journal_article","type-journal_article","status-publish","hentry","topic-infectious-diseases","topic-public-health"],"acf":{"citation":"Navarro C, Lau C, Buchan SA, Burchell AN, Nasreen S, Friedman L, Okpokoro E, Austin PC, Tan DHS, Gubbay JB, Kwong JC, Mishra S. <em>BMJ.<\/em> 2024; 386:e078243. Epub 2024 Sep 11.","source_url":"https:\/\/doi.org\/10.1136\/bmj-2023-078243","ices_scientist":[1161,1171,1385,1149,1320],"site":[6733],"research_program":[6745],"news_release":[20305],"journal_article":"","atlas":"","research_report":"","infographic":[20384],"video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Effectiveness of modified vaccinia Ankara-Bavarian Nordic vaccine against mpox infection: emulation of a target trial<\/title>\n<meta name=\"description\" content=\"Objective \u2014\u00a0To estimate the real world effectiveness of modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine against mpox infection. 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