{"id":20147,"date":"2024-07-08T10:16:00","date_gmt":"2024-07-08T14:16:00","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=20147"},"modified":"2024-08-15T10:25:36","modified_gmt":"2024-08-15T14:25:36","slug":"adherence-to-guideline-recommended-care-of-late-onset-hypertension-in-females-versus-males","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/adherence-to-guideline-recommended-care-of-late-onset-hypertension-in-females-versus-males\/","title":{"rendered":"Adherence to guideline-recommended care of late-onset hypertension in females versus males: a population-based cohort study"},"content":{"rendered":"<p><strong>Background <\/strong>\u2014 Sex-based disparities in cardiovascular outcomes may be improved with appropriate hypertension management.<\/p>\n<p><strong>Objective<\/strong> \u2014 To compare the evidence-based evaluation and management of females with late-onset hypertension compared to males in the contemporary era.<\/p>\n<p><strong>Methods<\/strong> \u2014 Design: Retrospective population-based cohort study.<\/p>\n<p><strong>Setting<\/strong> \u2014 Ontario, Canada.<\/p>\n<p><strong>Participants<\/strong> \u2014 Residents aged \u226566 years with newly diagnosed hypertension between January 1, 2010, and December 31, 2017.<\/p>\n<p><strong>Exposure<\/strong> \u2014 Sex (female vs. male).<\/p>\n<p><strong>Outcomes and measures <\/strong>\u2014 We used Poisson and logistic regression to estimate adjusted sex-attributable differences in the performance of guideline-recommended lab investigations. We estimated adjusted differences in time to the prescription of, and type of, first antihypertensive medication prescribed between females and males, using Cox regression.<\/p>\n<p><strong>Results<\/strong> \u2014 Among 111,410 adults (mean age 73 years, 53% female, median follow-up 6.8 years), females underwent a similar number of guideline-recommended investigations (adjusted incidence rate ratio, 0.997 [95% confidence interval [CI] 0.99-1.002]) compared to males. Females were also as likely to complete all investigations (0.70% females, 0.77% males; adjusted odds ratio, 0.96 [95% CI 0.83-1.11]). Females were slightly less likely to be prescribed medication (adjusted hazard ratio [aHR] 0.98 [95% CI 0.96-0.99]) or, among those prescribed, less likely to be prescribed first-line medication (aHR, 0.995 [95% CI 0.994-0.997]).<\/p>\n<p><strong>Conclusions<\/strong> \u2014 Compared to males, females with late-onset hypertension were equally likely to complete initial investigations with comparable prescription rates. These findings suggest that there may be no clinically meaningful sex-based differences in the initial management of late-onset hypertension to explain sex-based disparities in cardiovascular outcomes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 Sex-based disparities in cardiovascular outcomes may be improved with appropriate hypertension management. Objective \u2014 To compare the evidence-based evaluation and management of females with late-onset hypertension compared to males in the contemporary era. Methods \u2014 Design: Retrospective population-based cohort study. Setting \u2014 Ontario, Canada. Participants \u2014 Residents aged \u226566 years with newly diagnosed [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[40,62],"migration-helper-qa-sample-set":[],"class_list":["post-20147","journal_article","type-journal_article","status-publish","hentry","topic-cardiovascular-disease","topic-health-services-research"],"acf":{"citation":"Bugeja A, Girard C, Sood MM, Kendall CE, Sweet A, Singla R, Motazedian P, Vinson AJ, Ruzicka M, Hundemer GL, Knoll G, McIsaac DI. <em>J Intern Med<\/em>. 2024; Jul 8 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.1111\/joim.13821","ices_scientist":[1157,1264,1319,20606],"site":[6734],"research_program":[6747],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Adherence to guideline-recommended care of late-onset hypertension in females versus males: a population-based cohort study<\/title>\n<meta name=\"description\" content=\"Background \u2014 Sex-based disparities in cardiovascular outcomes may be improved with appropriate hypertension management. 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