{"id":20145,"date":"2024-04-25T10:02:00","date_gmt":"2024-04-25T14:02:00","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=20145"},"modified":"2024-08-15T10:05:58","modified_gmt":"2024-08-15T14:05:58","slug":"sex-related-disparities-in-cardiovascular-outcomes-among-older-adults-with-late-onset-hypertension","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/sex-related-disparities-in-cardiovascular-outcomes-among-older-adults-with-late-onset-hypertension\/","title":{"rendered":"Sex-related disparities in cardiovascular outcomes among older adults with late-onset hypertension"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 It is unclear whether sex-based differences in cardiovascular outcomes exist in late-onset hypertension.<\/p>\n<p><strong>Methods<\/strong> \u2014 This is a population-based cohort study in Ontario, Canada of 266 273 adults, aged \u226566 years with newly diagnosed hypertension. We determined the incidence of the primary composite cardiovascular outcome (myocardial infarction, stroke, and congestive heart failure), all-cause mortality, and cardiovascular death by sex using Cox proportional hazard models adjusted for demographic factors and comorbidities.<\/p>\n<p><strong>Results<\/strong> \u2014 The mean age of the total cohort was 74 years, and 135 531 (51%) were female. Over a median follow-up of 6.6 (4.7-9.0) years, females experienced a lower crude incidence rate (per 1000 person-years) than males for the primary composite cardiovascular outcome (287.3 versus 311.7), death (238.4 versus 251.4), and cardiovascular death (395.7 versus 439.6), P&lt;0.001. The risk of primary composite cardiovascular outcome was lower among females (adjusted hazard ratio, 0.75 [95% CI, 0.73-0.76]; P&lt;0.001) than in males. This was consistent after adjusting for the competing risk of all-cause death with a subdistributional hazard ratio, 0.88 ([95% CI, 0.86-0.91]; P&lt;0.001).<\/p>\n<p><strong>Conclusions <\/strong>\u2014 Females had a lower risk of cardiovascular outcomes compared with males within a population characterized by advanced age and new hypertension. Our results highlight that the severity of outcomes is influenced by sex in relation to the age at which hypertension is diagnosed. Further studies are required to identify sex-specific variations in the diagnosis and management of late-onset hypertension due to its high incidence in this group.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 It is unclear whether sex-based differences in cardiovascular outcomes exist in late-onset hypertension. Methods \u2014 This is a population-based cohort study in Ontario, Canada of 266 273 adults, aged \u226566 years with newly diagnosed hypertension. We determined the incidence of the primary composite cardiovascular outcome (myocardial infarction, stroke, and congestive heart failure), all-cause [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[40,17],"migration-helper-qa-sample-set":[],"class_list":["post-20145","journal_article","type-journal_article","status-publish","hentry","topic-cardiovascular-disease","topic-older-people"],"acf":{"citation":"Bugeja A, Girard C, Sood MM, Kendall CE, Sweet A, Singla R, Motazedian P, Vinson AJ, Ruzicka M, Hundemer GL, Knoll G, McIsaac DI. <em>Hypertension<\/em>. 2024 Jul; 81(7):1583-1591. Epub 2024 Apr 25.","source_url":"https:\/\/doi.org\/10.1161\/hypertensionaha.124.22870","ices_scientist":[1319,1264,1157,20606],"site":[6734],"research_program":[6747],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Sex-related disparities in cardiovascular outcomes among older adults with late-onset hypertension<\/title>\n<meta name=\"description\" content=\"Background \u2014 It is unclear whether sex-based differences in cardiovascular outcomes exist in late-onset hypertension. 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