{"id":20135,"date":"2024-04-29T16:10:00","date_gmt":"2024-04-29T20:10:00","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=20135"},"modified":"2024-08-12T16:19:25","modified_gmt":"2024-08-12T20:19:25","slug":"an-interrupted-time-series-analysis-of-the-impact-of-covid-19-on-hospitalizations-for-vascular-events-in-three-canadian-provinces","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/an-interrupted-time-series-analysis-of-the-impact-of-covid-19-on-hospitalizations-for-vascular-events-in-three-canadian-provinces\/","title":{"rendered":"An interrupted time-series analysis of the impact of COVID-19 on hospitalizations for vascular events in three Canadian provinces"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 COVID-19 infection is associated with a pro-coagulable state, thrombosis, and cardiovascular events. However, its impact on population-based rates of vascular events is less well understood. We studied temporal trends in hospitalizations for stroke and myocardial infarction in 3 Canadian provinces (Alberta, Ontario, and Nova Scotia) between 2014 and 2022.<\/p>\n<p><strong>Methods<\/strong> \u2014 Linked administrative data from each province were used to identify admissions for ischemic stroke, intracerebral hemorrhage, cerebral venous thrombosis, and myocardial infarction. Event rates per 100,000\/quarter, standardized to the 2016 Canadian population, were calculated. We assessed changes from quarterly rates pre-pandemic (2014-2020), compared to rates in the pandemic period (2020-2022), using interrupted time-series analysis with a jump discontinuity at pandemic onset. Age group\u2013 and sex-stratified analyses also were performed.<\/p>\n<p><strong>Results<\/strong> \u2014 We identified 162,497 strokes and 243,182 myocardial infarctions. At pandemic onset, no significant step change in strokesper 100,000\/quarter was observed in any of the 3 provinces. During the pandemic, stroke rates were stable in Alberta and Ontario, but they increased in Nova Scotia (0.44 per 100,000\/quarter, P = 0.004). At pandemic onset, a significant step decrease occurred in myocardial infarctions per 100,000\/quarter in Alberta (4.72, P &lt; 0.001) and Ontario (4.84, P &lt; 0.001), but not in Nova Scotia. During the pandemic, myocardial infarctions per 100,000\/quarter decreased in Alberta (\u20130.34, P = 0.01), but they remained stable in Ontario and Nova Scotia. No consistent patterns by age group or sex were noted.<\/p>\n<p><strong>Conclusions<\/strong> \u2014 Hospitalization rates for stroke or myocardial infarction across 3 Canadian provinces did not increase substantially during the first 2 years of the pandemic. Continued surveillance is warranted as the virus becomes endemic.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 COVID-19 infection is associated with a pro-coagulable state, thrombosis, and cardiovascular events. However, its impact on population-based rates of vascular events is less well understood. We studied temporal trends in hospitalizations for stroke and myocardial infarction in 3 Canadian provinces (Alberta, Ontario, and Nova Scotia) between 2014 and 2022. Methods \u2014 Linked administrative [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[24,40,35],"migration-helper-qa-sample-set":[],"class_list":["post-20135","journal_article","type-journal_article","status-publish","hentry","topic-acute-and-emergency-services","topic-cardiovascular-disease","topic-public-health"],"acf":{"citation":"Holodinsky JK, Kumar M, McNaughton CD, Austin PC, Chu A, Hill MD, Norris C, Field TS, Lee DS, Kapral MK, Kamal N, Yu AYX. <em>CJC Open<\/em>. 2024; 6(8)959-966. Epub 2024 Apr 29.","source_url":"https:\/\/doi.org\/10.1016\/j.cjco.2024.04.010","ices_scientist":[1298,19849,1385,1290,1150],"site":[6733],"research_program":[6742],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | An interrupted time-series analysis of the impact of COVID-19 on hospitalizations for vascular events in three Canadian provinces<\/title>\n<meta name=\"description\" content=\"Background \u2014 COVID-19 infection is associated with a pro-coagulable state, thrombosis, and cardiovascular events. 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