{"id":1994,"date":"2022-06-07T00:00:00","date_gmt":"2022-06-07T04:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\/"},"modified":"2023-06-14T19:44:31","modified_gmt":"2023-06-14T23:44:31","slug":"hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\/","title":{"rendered":"Hospitalization with Clostridioides difficile in pediatric inflammatory bowel disease: a population-based study"},"content":{"rendered":"<p><strong>Objectives<\/strong> &#x2014; Several studies have demonstrated higher rates of Clostridioides difficile infection (CDI) in adults with inflammatory bowel disease (IBD). We conducted a population-based study comparing the risk of hospitalization with CDI in children with and without IBD.<\/p>\n<p><strong>Methods<\/strong> &#x2014; Using health administrative data and validated algorithms, we identified all children (&lt;16 years) diagnosed with IBD in five Canadian provinces, then age- and sex-matched to 5 children without IBD. Province-specific five-year incidence rates of hospitalization with CDI were pooled and generalized linear mixed-effects models were used to estimate the crude incidence rate ratio (IRR) comparing (1) children with and without IBD and (2) children with Crohn&#x2019;s disease and ulcerative colitis. Hazard ratios (HR) from Cox proportional hazards models adjusting for age, sex, rural\/urban household, and income were pooled using fixed effects models.<\/p>\n<p><strong>Results<\/strong> &#x2014; The incidence rate of CDI identified during hospitalization was 49.06 (95% CI 39.40-61.08) per 10,000 person-years (PY) in 3593 children with IBD compared to 0.39 (95% CI 0.13-1.21) per 10,000 PY in 16,284 children without IBD (crude IRR 133.4, 95% CI 42.1-422.7; adjusted HR 68.2, 95% CI 24.4-190.4). CDI was identified less often in children with Crohn&#x2019;s disease than ulcerative colitis (crude IRR 0.51, 95% CI 0.32-0.82; adjusted HR 0.69, 95% CI 0.46-1.05).<\/p>\n<p><strong>Conclusions<\/strong> &#x2014; Children with IBD have a markedly higher incidence of CDI identified during a hospitalization relative to children without IBD. Consequently, symptomatic children with IBD who are hospitalized should be screened for CDI.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Objectives &#x2014; Several studies have demonstrated higher rates of Clostridioides difficile infection (CDI) in adults with inflammatory bowel disease (IBD). We conducted a population-based study comparing the risk of hospitalization with CDI in children with and without IBD. Methods &#x2014; Using health administrative data and validated algorithms, we identified all children (&lt;16 years) diagnosed with [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-1994","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Kuenzig ME, Benchimol EI, Bernstein CN, Bitton A, Carroll MW, Griffiths AM, Kaplan GG, Nguyen GC, Otley AR, Stukel TA, Dummer TJB, El-Matary W, Jacobson K, Jones JL, Lix LM, Mack DR, Murthy SK, Pe&#xf1;a-S&#xe1;nchez J, Targownik LE, Fung SG, Spruin S, Coward S, Cui Y, Filliter C, Nugent Z, Siddiq S, Singh H; on behalf of the Canadian Gastro-Intestinal Epidemiology Consortium (CanGIEC). <em>J Pediatr Gastroenterol Nutr<\/em>. 2022; 75(2):173-80. Epub 2022 Jun 7.","source_url":"https:\/\/journals.lww.com\/jpgn\/Abstract\/9900\/Hospitalization_with_Clostridioides_difficile_in.63.aspx","ices_scientist":[1372,1174,1301,21974],"site":[6734],"research_program":[6740],"news_release":[],"journal_article":[],"atlas":[],"research_report":[],"infographic":[],"video":[],"downloads":null,"links":null,"sitecore_item_id":"1E6D3D67-2623-436B-A18F-78FC475C13CC","sitecore_item_name":"Hospitalization-with-Clostridioides-difficile-in-pediatric-inflammatory-bowel-disease","sitecore_field_values":"{\n  \"Title\": \"Hospitalization with Clostridioides difficile in pediatric inflammatory bowel disease: a population-based study\",\n  \"Short title\": \"Hospitalization with Clostridioides\",\n  \"Summary\": \"This study found that children with IBD have a markedly higher incidence of Clostridioides difficile infection identified during a hospitalization relative to children without IBD.\",\n  \"Citation\": \"<p>Kuenzig ME, Benchimol EI, Bernstein CN, Bitton A, Carroll MW, Griffiths AM, Kaplan GG, Nguyen GC, Otley AR, Stukel TA, Dummer TJB, El-Matary W, Jacobson K, Jones JL, Lix LM, Mack DR, Murthy SK, Pe&ntilde;a-S&aacute;nchez J, Targownik LE, Fung SG, Spruin S, Coward S, Cui Y, Filliter C, Nugent Z, Siddiq S, Singh H; on behalf of the Canadian Gastro-Intestinal Epidemiology Consortium (CanGIEC). <em>J Pediatr Gastroenterol Nutr<\/em>. 2022; 75(2):173-80. Epub 2022 Jun 7. DOI: <a href=\"https:\/\/doi.org\/10.1097\/MPG.0000000000003489\" title=\"opens external link\">https:\/\/doi.org\/10.1097\/MPG.0000000000003489<\/a><\/p>\",\n  \"Abstract\": \"<p><strong>Objectives<\/strong> &mdash; Several studies have demonstrated higher rates of Clostridioides difficile infection (CDI) in adults with inflammatory bowel disease (IBD). We conducted a population-based study comparing the risk of hospitalization with CDI in children with and without IBD.<\/p>n<p><strong>Methods<\/strong> &mdash; Using health administrative data and validated algorithms, we identified all children (&lt;16 years) diagnosed with IBD in five Canadian provinces, then age- and sex-matched to 5 children without IBD. Province-specific five-year incidence rates of hospitalization with CDI were pooled and generalized linear mixed-effects models were used to estimate the crude incidence rate ratio (IRR) comparing (1) children with and without IBD and (2) children with Crohn&rsquo;s disease and ulcerative colitis. Hazard ratios (HR) from Cox proportional hazards models adjusting for age, sex, rural\/urban household, and income were pooled using fixed effects models.<\/p>n<p><strong>Results<\/strong> &mdash; The incidence rate of CDI identified during hospitalization was 49.06 (95% CI 39.40-61.08) per 10,000 person-years (PY) in 3593 children with IBD compared to 0.39 (95% CI 0.13-1.21) per 10,000 PY in 16,284 children without IBD (crude IRR 133.4, 95% CI 42.1-422.7; adjusted HR 68.2, 95% CI 24.4-190.4). CDI was identified less often in children with Crohn&rsquo;s disease than ulcerative colitis (crude IRR 0.51, 95% CI 0.32-0.82; adjusted HR 0.69, 95% CI 0.46-1.05).<\/p>n<p><strong>Conclusions<\/strong> &mdash; Children with IBD have a markedly higher incidence of CDI identified during a hospitalization relative to children without IBD. Consequently, symptomatic children with IBD who are hospitalized should be screened for CDI.<\/p>n<p><a href=\"https:\/\/journals.lww.com\/jpgn\/Abstract\/9900\/Hospitalization_with_Clostridioides_difficile_in.63.aspx\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Research Programs\": \"{46DF28D2-EDE8-4DF2-8CC0-87CEF464E435}\",\n  \"ICES Locations\": \"{0AD77E2C-C883-4E93-8B9A-40B82D50E3A5}\",\n  \"ICES Scientists\": \"{A0978F87-1C10-4E62-A833-89616146CA59}|{85C78233-ED47-42C4-BF65-524CF15A8219}|{B745F78B-F800-48D1-96E0-706773D0C8C8}\",\n  \"Posted Date\": \"20220607T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2022\/June\/Hospitalization-with-Clostridioides-difficile-in-pediatric-inflammatory-bowel-disease"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Hospitalization with Clostridioides difficile in pediatric inflammatory bowel disease: a population-based study<\/title>\n<meta name=\"description\" content=\"Objectives &#x2014; Several studies have demonstrated higher rates of Clostridioides difficile infection (CDI) in adults with inflammatory bowel disease\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Hospitalization with Clostridioides difficile in pediatric inflammatory bowel disease: a population-based study\" \/>\n<meta property=\"og:description\" content=\"Objectives &#x2014; Several studies have demonstrated higher rates of Clostridioides difficile infection (CDI) in adults with inflammatory bowel disease\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\/\" \/>\n<meta property=\"og:site_name\" content=\"ICES\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ICESOntario\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-14T23:44:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\\\/\",\"name\":\"ICES | Hospitalization with Clostridioides difficile in pediatric inflammatory bowel disease: a population-based study\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\"},\"datePublished\":\"2022-06-07T04:00:00+00:00\",\"dateModified\":\"2023-06-14T23:44:31+00:00\",\"description\":\"Objectives &#x2014; Several studies have demonstrated higher rates of Clostridioides difficile infection (CDI) in adults with inflammatory bowel disease\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Journal Articles\",\"item\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Hospitalization with Clostridioides difficile in pediatric inflammatory bowel disease: a population-based study\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\",\"name\":\"ICES\",\"description\":\"POPULATION-BASED HEALTH RESEARCH THAT MAKES A DIFFERENCE\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#organization\"},\"alternateName\":\"Institute for Clinical Evaluative Sciences\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#organization\",\"name\":\"ICES\",\"alternateName\":\"Institute for Clinical Evaluative Sciences\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/ices-logo.png\",\"contentUrl\":\"https:\\\/\\\/www.ices.on.ca\\\/wp-content\\\/uploads\\\/2023\\\/04\\\/ices-logo.png\",\"width\":\"676\",\"height\":\"618\",\"caption\":\"ICES\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/ICESOntario\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/ices-research-institute\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"ICES | Hospitalization with Clostridioides difficile in pediatric inflammatory bowel disease: a population-based study","description":"Objectives &#x2014; Several studies have demonstrated higher rates of Clostridioides difficile infection (CDI) in adults with inflammatory bowel disease","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\/","og_locale":"fr_FR","og_type":"article","og_title":"ICES | Hospitalization with Clostridioides difficile in pediatric inflammatory bowel disease: a population-based study","og_description":"Objectives &#x2014; Several studies have demonstrated higher rates of Clostridioides difficile infection (CDI) in adults with inflammatory bowel disease","og_url":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\/","og_site_name":"ICES","article_publisher":"https:\/\/www.facebook.com\/ICESOntario\/","article_modified_time":"2023-06-14T23:44:31+00:00","og_image":[{"width":1200,"height":675,"url":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\/","url":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\/","name":"ICES | Hospitalization with Clostridioides difficile in pediatric inflammatory bowel disease: a population-based study","isPartOf":{"@id":"https:\/\/www.ices.on.ca\/fr\/#website"},"datePublished":"2022-06-07T04:00:00+00:00","dateModified":"2023-06-14T23:44:31+00:00","description":"Objectives &#x2014; Several studies have demonstrated higher rates of Clostridioides difficile infection (CDI) in adults with inflammatory bowel disease","breadcrumb":{"@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/hospitalization-with-clostridioides-difficile-in-pediatric-inflammatory-bowel-disease-a-population-based-study\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.ices.on.ca\/fr\/"},{"@type":"ListItem","position":2,"name":"Journal Articles","item":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/"},{"@type":"ListItem","position":3,"name":"Hospitalization with Clostridioides difficile in pediatric inflammatory bowel disease: a population-based study"}]},{"@type":"WebSite","@id":"https:\/\/www.ices.on.ca\/fr\/#website","url":"https:\/\/www.ices.on.ca\/fr\/","name":"ICES","description":"POPULATION-BASED HEALTH RESEARCH THAT MAKES A DIFFERENCE","publisher":{"@id":"https:\/\/www.ices.on.ca\/fr\/#organization"},"alternateName":"Institute for Clinical Evaluative Sciences","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.ices.on.ca\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/www.ices.on.ca\/fr\/#organization","name":"ICES","alternateName":"Institute for Clinical Evaluative Sciences","url":"https:\/\/www.ices.on.ca\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.ices.on.ca\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/04\/ices-logo.png","contentUrl":"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2023\/04\/ices-logo.png","width":"676","height":"618","caption":"ICES"},"image":{"@id":"https:\/\/www.ices.on.ca\/fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/ICESOntario\/","https:\/\/www.linkedin.com\/company\/ices-research-institute\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/journal_article\/1994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/journal_article"}],"about":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/types\/journal_article"}],"acf:post":[{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/research_program\/6740"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/site\/6734"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/21974"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1301"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1174"},{"embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/ices_scientist\/1372"}],"wp:attachment":[{"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/media?parent=1994"}],"wp:term":[{"taxonomy":"migration-helper-automated","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-helper-automated?post=1994"},{"taxonomy":"migration-manual","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-manual?post=1994"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/topic?post=1994"},{"taxonomy":"migration-helper-qa-sample-set","embeddable":true,"href":"https:\/\/www.ices.on.ca\/fr\/wp-json\/wp\/v2\/migration-helper-qa-sample-set?post=1994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}