{"id":19918,"date":"2024-07-26T08:40:00","date_gmt":"2024-07-26T12:40:00","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=19918"},"modified":"2024-07-25T15:44:18","modified_gmt":"2024-07-25T19:44:18","slug":"comparison-of-covid-19-hospitalization-and-death-between-solid-organ-transplant-recipients-and-the-general-population-in-canada-2020-2022","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/comparison-of-covid-19-hospitalization-and-death-between-solid-organ-transplant-recipients-and-the-general-population-in-canada-2020-2022\/","title":{"rendered":"Comparison of COVID-19 hospitalization and death between solid organ transplant recipients and the general population in Canada, 2020-2022"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 Solid organ transplant recipients have a high risk of severe outcomes from SARS-CoV-2 infection. A comprehensive understanding of the impact of the COVID-19 pandemic across multiple waves in the solid organ transplant population and how this compares to the general population is limited. We conducted a population-based cohort study using linked administrative healthcare databases from Ontario, Canada to answer this question.<\/p>\n<p><strong>Methods<\/strong> \u2014 We included 15 306 solid organ transplant recipients and 12 160 904 individuals from the general population. Our primary outcome was the rate (per 100 person-years) of severe COVID-19 (ie, hospitalization or death with a positive SARS-CoV-2 test) occurring between January 25, 2020, and November 30, 2022.<\/p>\n<p><strong>Results<\/strong> \u2014 Compared with the general population, solid organ transplant recipients had almost a 6 times higher rate of severe COVID-19 (20.39 versus 3.44 per 100 person-years), with almost 5.5 times as high a rate of death alone (4.19 versus 0.77 per 100 person-years). Transplant recipients with severe COVID-19 were substantially younger (60.1 versus 66.5 y) and had more comorbidities. The rate of severe COVID-19 declined over time in the solid organ transplant population, with an incidence rate of 41.25 per 100 person-years in the first wave (January 25, 2020, to August 31, 2020) and 18.41 in the seventh wave (June 19, 2022, to November 30, 2022, Omicron era).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 Solid organ transplant recipients have a high risk of severe outcomes from SARS-CoV-2 infection. A comprehensive understanding of the impact of the COVID-19 pandemic across multiple waves in the solid organ transplant population and how this compares to the general population is limited. We conducted a population-based cohort study using linked administrative healthcare [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[24,39,54],"migration-helper-qa-sample-set":[],"class_list":["post-19918","journal_article","type-journal_article","status-publish","hentry","topic-acute-and-emergency-services","topic-infectious-diseases","topic-organ-transplantation-and-donation"],"acf":{"citation":"Naylor KL, Knoll GA, Treleaven D, Kang Y, Garg AX, Stirling K, Kim SJ. <em>Transplant Direct<\/em>. 2024; 10(7):e1670.","source_url":"https:\/\/doi.org\/10.1097\/txd.0000000000001670","ices_scientist":[1299,1242,1153],"site":[6739],"research_program":[6743],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Comparison of COVID-19 hospitalization and death between solid organ transplant recipients and the general population in Canada, 2020-2022<\/title>\n<meta name=\"description\" content=\"Background \u2014 Solid organ transplant recipients have a high risk of severe outcomes from SARS-CoV-2 infection. 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