{"id":19892,"date":"2024-06-25T11:11:00","date_gmt":"2024-06-25T15:11:00","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&p=19892"},"modified":"2024-07-25T11:16:06","modified_gmt":"2024-07-25T15:16:06","slug":"a-population-based-matched-cohort-study-of-digestive-system-cancer-incidence-and-mortality-in-individuals-with-and-without-inflammatory-bowel-disease","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/a-population-based-matched-cohort-study-of-digestive-system-cancer-incidence-and-mortality-in-individuals-with-and-without-inflammatory-bowel-disease\/","title":{"rendered":"A population-based matched cohort study of digestive system cancer incidence and mortality in individuals with and without inflammatory bowel disease"},"content":{"rendered":"

Introduction<\/strong> \u2014 To study digestive system cancer risks in inflammatory bowel diseases (IBD) in the biologic era.<\/p>\n

Methods<\/strong> \u2014 We used population-level administrative and cancer registry data from Ontario, Canada (1994 – 2020) to compare people with IBD to matched controls (1:10 by sex and birth year) on trends in age-sex standardized cancer incidence and risk ratios of incident cancers and cancer-related deaths.<\/p>\n

Results<\/strong> \u2014 Among 110,919 IBD and 1,109,190 controls, colorectal cancer (CRC) incidence (per 100,000 person-years) declined similarly in people with ulcerative colitis (average annual percentage change (AAPC) -1.81; 95% CI, -2.48, -1.156) and controls (AAPC -2.79; 95% CI, -3.44, -2.14), while small bowel cancer incidence rose faster in those with Crohn’s disease (AAPC 9.68; 95% CI, 2.51, 17.3) than controls (AAPC 3.64; 95% CI, 1.52, 5.80). Extra-intestinal digestive cancer incidence rose faster in people with IBD (AAPC 3.27; 95% CI, 1.83, 4.73) than controls (AAPC -1.87; 95% CI, -2.33, -1.42), particularly for liver (IBD AAPC 8.48; 95% CI, 4.11, 13.1) and bile duct (IBD AAPC 7.22; 95 % CI, 3.74, 10.8) cancers. Beyond 2010, the incidences (and respective mortality rates) of colorectal (1.60; 95% CI, 1.46, 1.75), small bowel (4.10; 95% CI 3.37, 4.99), bile duct (2.33; 95% CI 1.96, 2.77) and pancreatic (1.19; 95% CI, 1.00, 1.40) cancers, were higher in people with IBD.<\/p>\n

Discussion<\/strong> \u2014 Cancer incidence is declining for CRC and rising for other digestive cancers in people with IBD. Incidence and mortality remain higher in IBD than controls for colorectal, small bowel, bile duct and pancreatic cancers.<\/p>\n","protected":false},"excerpt":{"rendered":"

Introduction \u2014 To study digestive system cancer risks in inflammatory bowel diseases (IBD) in the biologic era. Methods \u2014 We used population-level administrative and cancer registry data from Ontario, Canada (1994 – 2020) to compare people with IBD to matched controls (1:10 by sex and birth year) on trends in age-sex standardized cancer incidence and […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[38,48,46],"migration-helper-qa-sample-set":[],"class_list":["post-19892","journal_article","type-journal_article","status-publish","hentry","topic-cancer-and-cancer-screening","topic-gastroenterology","topic-internal-medicine"],"acf":{"citation":"Murthy SK, Tandon P, Matthews P, Ahmed F, Pugliese M, Taljaard M, Kaplan GG, Coward S, Bernstein C, Benchimol EI, Kuenzig ME, Targownik LE, Singh H; Canadian Gastro-Intestinal Epidemiology Consortium (CanGIEC). Am J Gastroenterol<\/em>. 2024; Jun 25 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.14309\/ajg.0000000000002900","ices_scientist":[1317,1174,20863,21974],"site":[6734],"research_program":[6740],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"\nICES | A population-based matched cohort study of digestive system cancer incidence and mortality in individuals with and without inflammatory bowel disease<\/title>\n<meta name=\"description\" content=\"Introduction \u2014 To study digestive system cancer risks in inflammatory bowel diseases (IBD) in the biologic era. 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