{"id":1771,"date":"2022-11-14T00:00:00","date_gmt":"2022-11-14T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/epilepsy-surgery-in-adult-stroke-survivors-with-new-onset-drug-resistant-epilepsy\/"},"modified":"2023-11-30T14:10:24","modified_gmt":"2023-11-30T19:10:24","slug":"epilepsy-surgery-in-adult-stroke-survivors-with-new-onset-drug-resistant-epilepsy","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/epilepsy-surgery-in-adult-stroke-survivors-with-new-onset-drug-resistant-epilepsy\/","title":{"rendered":"Epilepsy surgery in adult stroke survivors with new-onset drug-resistant epilepsy"},"content":{"rendered":"<p><strong>Background<\/strong> &#x2014; Despite its effectiveness, surgery for drug-resistant epilepsy is underutilized. However, whether epilepsy surgery is also underutilized among patients with stroke-related drug-resistant epilepsy is unclear. Therefore, our objectives were to estimate the rates of epilepsy surgery assessment and receipt among patients with stroke-related drug-resistant epilepsy and to identify factors associated with these outcomes.<\/p>\n<p><strong>Methods<\/strong> &#x2014; We used linked health administrative databases to conduct a population-based retrospective cohort study of adult Ontario, Canada residents discharged from an Ontario acute care institution following the treatment of a stroke between January 1, 1997, and December 31, 2020, without prior evidence of seizures. We excluded patients who did not subsequently develop drug-resistant epilepsy and those with other epilepsy risk factors. We estimated the rates of epilepsy surgery assessment and receipt by March 31, 2021. We planned to use Fine-Gray subdistribution hazard models to identify covariates independently associated with our outcomes, controlling for the competing risk of death.<\/p>\n<p><strong>Results<\/strong> &#x2014; We identified 265,081 patients who survived until discharge following inpatient stroke treatment, 1,902 (0.7%) of whom subsequently developed drug-resistant epilepsy (805 women; mean age: 67.0 &#xb1; 13.1 years). Fewer than six (&#x2264;0.3%) of these patients were assessed for or received epilepsy surgery before the end of follow-up (&#x2264;55.5 per 100,000 person-years). Given that few outcomes were identified, we could not proceed with the multivariable analyses.<\/p>\n<p><strong>Conclusions<\/strong> &#x2014; Patients with stroke-related drug-resistant epilepsy are infrequently considered for epilepsy surgery that could reduce morbidity and mortality.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background &#x2014; Despite its effectiveness, surgery for drug-resistant epilepsy is underutilized. However, whether epilepsy surgery is also underutilized among patients with stroke-related drug-resistant epilepsy is unclear. Therefore, our objectives were to estimate the rates of epilepsy surgery assessment and receipt among patients with stroke-related drug-resistant epilepsy and to identify factors associated with these outcomes. Methods [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[],"migration-helper-qa-sample-set":[],"class_list":["post-1771","journal_article","type-journal_article","status-publish","hentry"],"acf":{"citation":"Antaya TC, Le BN, Richard L, Qureshi A, Shariff SZ, Sposato LA, Burneo JG. <em>Can J Neurol Sci<\/em>. 2023; 50(5):673-8. Epub 2022 Nov 14.","source_url":"https:\/\/www.cambridge.org\/core\/journals\/canadian-journal-of-neurological-sciences\/article\/epilepsy-surgery-in-adult-stroke-survivors-with-newonset-drugresistant-epilepsy\/2A956447902CBF08DEF97991089DDFCE","ices_scientist":[1169,1359],"site":[6739],"research_program":[6742],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"A908BAAD-17A2-4F70-9836-D5DEA036E712","sitecore_item_name":"Epilepsy-surgery-in-adult-stroke-survivors-with-new-onset-drug-resistant-epilepsy","sitecore_field_values":"{\n  \"Title\": \"Epilepsy surgery in adult stroke survivors with new-onset drug-resistant epilepsy\",\n  \"Short title\": \"Epilepsy surgery in adult stroke\",\n  \"Summary\": \"This study found that patients with stroke-related drug-resistant epilepsy are infrequently considered for epilepsy surgery that could reduce morbidity and mortality.\",\n  \"Citation\": \"<p>Antaya TC, Le BN, Richard L, Qureshi A, Shariff SZ, Sposato LA, Burneo JG. <em>Can J Neurol Sci<\/em>. 2022; Nov 14 [Epub ahead of print]. DOI: <a href=\"https:\/\/doi.org\/10.1017\/cjn.2022.300\" title=\"opens external link\">https:\/\/doi.org\/10.1017\/cjn.2022.300<\/a><\/p>\",\n  \"Abstract\": \"<p><strong>Background<\/strong> &mdash; Despite its effectiveness, surgery for drug-resistant epilepsy is underutilized. However, whether epilepsy surgery is also underutilized among patients with stroke-related drug-resistant epilepsy is unclear. Therefore, our objectives were to estimate the rates of epilepsy surgery assessment and receipt among patients with stroke-related drug-resistant epilepsy and to identify factors associated with these outcomes.<\/p>n<p><strong>Methods<\/strong> &mdash; We used linked health administrative databases to conduct a population-based retrospective cohort study of adult Ontario, Canada residents discharged from an Ontario acute care institution following the treatment of a stroke between January 1, 1997, and December 31, 2020, without prior evidence of seizures. We excluded patients who did not subsequently develop drug-resistant epilepsy and those with other epilepsy risk factors. We estimated the rates of epilepsy surgery assessment and receipt by March 31, 2021. We planned to use Fine-Gray subdistribution hazard models to identify covariates independently associated with our outcomes, controlling for the competing risk of death.<\/p>n<p><strong>Results<\/strong> &mdash; We identified 265,081 patients who survived until discharge following inpatient stroke treatment, 1,902 (0.7%) of whom subsequently developed drug-resistant epilepsy (805 women; mean age: 67.0 &plusmn; 13.1 years). Fewer than six (&le;0.3%) of these patients were assessed for or received epilepsy surgery before the end of follow-up (&le;55.5 per 100,000 person-years). Given that few outcomes were identified, we could not proceed with the multivariable analyses.<\/p>n<p><strong>Conclusions<\/strong> &mdash; Patients with stroke-related drug-resistant epilepsy are infrequently considered for epilepsy surgery that could reduce morbidity and mortality.<\/p>n<p><a href=\"https:\/\/www.cambridge.org\/core\/journals\/canadian-journal-of-neurological-sciences\/article\/epilepsy-surgery-in-adult-stroke-survivors-with-newonset-drugresistant-epilepsy\/2A956447902CBF08DEF97991089DDFCE\" title=\"opens external link\">View full text<\/a><\/p>\",\n  \"Research Programs\": \"{BEC72DE0-BA8C-42B8-ACE5-EE29FFB2CB3B}\",\n  \"ICES Locations\": \"{3B4AF7E8-6835-410B-AEB8-360A79CA0ED8}\",\n  \"ICES Scientists\": \"{5800CF8C-9840-413D-B1BA-27422B322E2B}|{E8DA0CD3-1341-4EA5-846D-D3FCFCEB3137}\",\n  \"Posted Date\": \"20221114T000000\",\n  \"Show on Publications Landing Page\": \"1\"\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2022\/November\/Epilepsy-surgery-in-adult-stroke-survivors-with-new-onset-drug-resistant-epilepsy"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Epilepsy surgery in adult stroke survivors with new-onset drug-resistant epilepsy<\/title>\n<meta name=\"description\" content=\"Background &#x2014; Despite its effectiveness, surgery for drug-resistant epilepsy is underutilized. 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