{"id":17514,"date":"2024-03-08T14:07:33","date_gmt":"2024-03-08T19:07:33","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&p=17514"},"modified":"2024-03-11T14:14:56","modified_gmt":"2024-03-11T18:14:56","slug":"short-and-long-term-outcomes-of-acute-diverticulitis","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/short-and-long-term-outcomes-of-acute-diverticulitis\/","title":{"rendered":"Short- and long-term outcomes of acute diverticulitis in patients with transplanted kidneys"},"content":{"rendered":"

Aim<\/strong> \u2014 The safety of nonoperative treatment for patients with transplanted kidneys who develop acute diverticulitis is unclear. Our primary aim was to examine the long-term sequelae of nonoperative management in this group.<\/p>\n

Method<\/strong> \u2014 We performed a population-based retrospective cohort study using linked administrative databases housed at ICES in Ontario, Canada. We included adult (\u226518\u2009years) patients admitted with acute diverticulitis between April 2002 and December 2019. Patients with a functioning kidney transplant were compared with those without a transplant. The primary outcome was failure of conservative management (operation, drainage procedure or death due to acute diverticulitis) beyond 30\u2009days. The cumulative incidence function and a Fine\u2013Grey subdistribution hazard model were used to evaluate this outcome accounting for competing risks.<\/p>\n

Results<\/strong> \u2014 We examined 165 patients with transplanted kidneys and 74\u2009095 without. Patients with transplanted kidneys were managed conservatively 81% of the time at the index event versus 86% in nontransplant patients. Short-term outcomes were comparable, but cumulative failure of conservative management at 5\u2009years occurred in 5.6% (95% CI 2.3%\u201311.1%) of patients with transplanted kidneys versus 2.1% (95% CI 2.0%\u20132.3%) in those without. Readmission for acute diverticulitis was also higher in transplanted patients at 5\u2009years at 16.7% (95% CI 10.1%\u201324.7%) versus 11.6% (95% CI 11.3%\u201311.9%). Adjusted analyses showed increased failure of conservative management [subdistribution hazard ratio (sHR) 3.24, 95% CI 1.69\u20136.22] and readmissions (sHR 1.55, 95% CI 1.02\u20132.36) for patients with transplanted kidneys.<\/p>\n

Conclusion<\/strong> \u2014 Most patients with transplanted kidneys are managed conservatively for acute diverticulitis. Although long-term readmission and failure of conservative management is higher for this group than the nontransplant population, serious outcomes are infrequent, substantiating the safety of this approach.<\/p>\n","protected":false},"excerpt":{"rendered":"

Aim \u2014 The safety of nonoperative treatment for patients with transplanted kidneys who develop acute diverticulitis is unclear. Our primary aim was to examine the long-term sequelae of nonoperative management in this group. Method \u2014 We performed a population-based retrospective cohort study using linked administrative databases housed at ICES in Ontario, Canada. We included adult […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[42,48,49,54],"migration-helper-qa-sample-set":[],"class_list":["post-17514","journal_article","type-journal_article","status-publish","hentry","topic-chronic-diseases-and-multimorbidity","topic-gastroenterology","topic-kidney-disease","topic-organ-transplantation-and-donation"],"acf":{"citation":"Nantais J, Baxter NN, Saskin R, Calzavara A, Gomez D. Colorectal Dis<\/em>. 2024; Mar 8 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.1111\/codi.16941","ices_scientist":[1177,1360,1241],"site":[6733],"research_program":[6745],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"\nICES | Short- and long-term outcomes of acute diverticulitis in patients with transplanted kidneys<\/title>\n<meta name=\"description\" content=\"Aim \u2014 The safety of nonoperative treatment for patients with transplanted kidneys who develop acute diverticulitis is unclear. 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