{"id":17452,"date":"2024-02-15T13:20:52","date_gmt":"2024-02-15T18:20:52","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=17452"},"modified":"2024-02-20T13:32:41","modified_gmt":"2024-02-20T18:32:41","slug":"indirect-impact-of-childhood-13-valent-pneumococcal-conjugate-vaccine","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/indirect-impact-of-childhood-13-valent-pneumococcal-conjugate-vaccine\/","title":{"rendered":"Indirect impact of childhood 13-valent pneumococcal conjugate vaccine (PCV13) in Canadian older adults: a Canadian Immunization Research Network (CIRN) retrospective observational study"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 13-valent pneumococcal conjugate vaccine (PCV13) has been part of publicly funded childhood immunisation programmes in Ontario and British Columbia (BC) since 2010. We assessed the indirect impact of infant PCV13 programmes on invasive pneumococcal disease (IPD) and all-cause pneumonia hospitalisation in older adults (aged \u226565 years) using a retrospective observational study.<\/p>\n<p><strong>Methods<\/strong> \u2014 We extracted monthly IPD and all-cause pneumonia cases from laboratory and health administrative databases between January 2005 and December 2018. Using a quasi-experimental difference-in-differences design, we calculated the ratio of risk ratios (RRRs) using incidence rates of IPD or all-cause pneumonia cases before (pre-PCV13 period) and after (PCV13 period) 2010 with rates of fractures as controls.<\/p>\n<p><strong>Results<\/strong> \u2014 The rates of all IPD or PCV serotype-specific IPD for older adults in both Ontario and BC did not change in 8 years after childhood PCV13 programme implementation. All-cause pneumonia increased in Ontario (RRR 1.38, 95%\u2009CI 1.11 to 1.71) but remained unchanged in BC.<\/p>\n<p><strong>Conclusions<\/strong> \u2014 Indirect community protection of older adults from hospitalisation with pneumococcal disease stalled despite maturation of childhood PCV13 vaccination programmes in two Canadian provinces.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 13-valent pneumococcal conjugate vaccine (PCV13) has been part of publicly funded childhood immunisation programmes in Ontario and British Columbia (BC) since 2010. We assessed the indirect impact of infant PCV13 programmes on invasive pneumococcal disease (IPD) and all-cause pneumonia hospitalisation in older adults (aged \u226565 years) using a retrospective observational study. Methods \u2014 [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[39,35],"migration-helper-qa-sample-set":[],"class_list":["post-17452","journal_article","type-journal_article","status-publish","hentry","topic-infectious-diseases","topic-public-health"],"acf":{"citation":"Nasreen S, Wang J, Marra F, Kwong JC, McGeer A, Sadarangani M, Wilson SE, Fadel SA. <em>Thorax<\/em>. 2024; Feb 15 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.1136\/thorax-2023-220377","ices_scientist":[1149,1126],"site":[6735],"research_program":[6745],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Indirect impact of 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