{"id":1737,"date":"2022-12-06T00:00:00","date_gmt":"2022-12-06T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/association-of-topical-glaucoma-medications-with-lacrimal-drainage-obstruction-and-eyelid-malposition\/"},"modified":"2023-11-30T13:48:53","modified_gmt":"2023-11-30T18:48:53","slug":"association-of-topical-glaucoma-medications-with-lacrimal-drainage-obstruction-and-eyelid-malposition","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/association-of-topical-glaucoma-medications-with-lacrimal-drainage-obstruction-and-eyelid-malposition\/","title":{"rendered":"Association of topical glaucoma medications with lacrimal drainage obstruction and eyelid malposition"},"content":{"rendered":"<p><strong>Background\/objectives<\/strong> \u2014 Adverse effects of topical glaucoma medications (TGMs) may include development of ocular adnexal disorders. We undertook a study to determine the effect of TGMs on the risk of developing lacrimal drainage obstruction (LDO) and eyelid malposition.<\/p>\n<p><strong>Subjects\/methods<\/strong> \u2014 All patients 66 years of age and older in Ontario, Canada initiating TGM and all patients diagnosed with glaucoma\/suspected glaucoma but not receiving TGM from 2002 to 2018 were eligible for inclusion in this retrospective cohort study. Using validated healthcare administrative databases, cohorts were identified with TGM and no TGM patients matched 1:2 on sex and birth year. The effect of TGM treatment on risk of surgery for LDO and lid malpositions was estimated using Kaplan\u2013Meier and Cox proportional hazards models.<\/p>\n<p><strong>Results<\/strong> \u2014 Cohorts included 122,582 patients in the TGM cohort and 232,336 patients in the no TGM cohort. Among the TGM cohort there was decreased event-free survival for entropion (log-rank <em>P<\/em> &lt; 0.001), trichiasis (<em>P<\/em> &lt; 0.001), and LDO (<em>P<\/em> = 0.006), and increased ectropion-free survival (<em>P<\/em> = 0.007). No difference in ptosis-free survival was detected (<em>P<\/em> = 0.78). For the TGM cohort there were increased hazards for entropion (hazard ratio [HR] 1.24, 95% confidence interval [CI] 1.12\u20131.37; <em>P<\/em> &lt; 0.001), trichiasis (HR 1.74, 95% CI 1.57\u20131.94; <em>P<\/em> &lt; 0.001), and LDO (at 15 years: HR 2.39, 95% CI 1.49\u20133.85; <em>P<\/em> = 0.004), and a decreased hazard for ectropion (HR 0.89, 95% CI 0.81\u20130.97; <em>P<\/em> = 0.008). No association between TGM treatment and ptosis hazard was detected (HR 0.99, 95% CI 0.89\u20131.09; <em>P<\/em> = 0.78).<\/p>\n<p><strong>Conclusions<\/strong> \u2014 TGMs are associated with an increased risk of undergoing surgery for LDO, entropion, and trichiasis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background\/objectives \u2014 Adverse effects of topical glaucoma medications (TGMs) may include development of ocular adnexal disorders. We undertook a study to determine the effect of TGMs on the risk of developing lacrimal drainage obstruction (LDO) and eyelid malposition. Subjects\/methods \u2014 All patients 66 years of age and older in Ontario, Canada initiating TGM and all [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[43,56],"migration-helper-qa-sample-set":[],"class_list":["post-1737","journal_article","type-journal_article","status-publish","hentry","topic-eye-ear-nose-and-throat-disorders","topic-pharmacoepidemiology-and-drug-safety"],"acf":{"citation":"Quinn MP, Kratky V, Whitehead M, Gill SS, McIsaac MA, Campbell RJ. <em>Eye (Lond)<\/em>. 2023; 37(11):2233-9. Epub 2022 Dec 6.","source_url":"https:\/\/doi.org\/10.1038\/s41433-022-02322-w","ices_scientist":[1251,1203],"site":[6736],"research_program":[6746],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"2B887249-F003-4368-8B52-38F4D2D5CB6E","sitecore_item_name":"Association-of-topical-glaucoma-medications-with-lacrimal-drainage-obstruction","sitecore_field_values":"{\r\n  \"Title\": \"Association of topical glaucoma medications with lacrimal drainage obstruction and eyelid malposition\",\r\n  \"Short title\": \"Association of topical glaucoma\",\r\n  \"Summary\": \"This study determined the effect of topical glaucoma medications on the risk of developing lacrimal drainage obstruction and eyelid malposition.\",\r\n  \"Citation\": \"<p>Quinn MP, Kratky V, Whitehead M, Gill SS, McIsaac MA, Campbell RJ. <em>Eye (Lond)<\/em>. 2022; Dec 6 [Epub ahead of print]. DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41433-022-02322-w\" title=\"opens external link\">https:\/\/doi.org\/10.1038\/s41433-022-02322-w<\/a><\/p>\",\r\n  \"Abstract\": \"<p><strong>Background\/objectives<\/strong> &mdash; Adverse effects of topical glaucoma medications (TGMs) may include development of ocular adnexal disorders. We undertook a study to determine the effect of TGMs on the risk of developing lacrimal drainage obstruction (LDO) and eyelid malposition.<\/p>n<p><strong>Subjects\/methods<\/strong> &mdash; All patients 66 years of age and older in Ontario, Canada initiating TGM and all patients diagnosed with glaucoma\/suspected glaucoma but not receiving TGM from 2002 to 2018 were eligible for inclusion in this retrospective cohort study. Using validated healthcare administrative databases, cohorts were identified with TGM and no TGM patients matched 1:2 on sex and birth year. The effect of TGM treatment on risk of surgery for LDO and lid malpositions was estimated using Kaplan&ndash;Meier and Cox proportional hazards models.<\/p>n<p><strong>Results<\/strong> &mdash; Cohorts included 122,582 patients in the TGM cohort and 232,336 patients in the no TGM cohort. Among the TGM cohort there was decreased event-free survival for entropion (log-rank <em>P<\/em> &lt; 0.001), trichiasis (<em>P<\/em> &lt; 0.001), and LDO (<em>P<\/em> = 0.006), and increased ectropion-free survival (<em>P<\/em> = 0.007). No difference in ptosis-free survival was detected (<em>P<\/em> = 0.78). For the TGM cohort there were increased hazards for entropion (hazard ratio [HR] 1.24, 95% confidence interval [CI] 1.12&ndash;1.37; <em>P<\/em> &lt; 0.001), trichiasis (HR 1.74, 95% CI 1.57&ndash;1.94; <em>P<\/em> &lt; 0.001), and LDO (at 15 years: HR 2.39, 95% CI 1.49&ndash;3.85; <em>P<\/em> = 0.004), and a decreased hazard for ectropion (HR 0.89, 95% CI 0.81&ndash;0.97; <em>P<\/em> = 0.008). No association between TGM treatment and ptosis hazard was detected (HR 0.99, 95% CI 0.89&ndash;1.09; <em>P<\/em> = 0.78).<\/p>n<p><strong>Conclusions<\/strong> &mdash; TGMs are associated with an increased risk of undergoing surgery for LDO, entropion, and trichiasis.<\/p>\",\r\n  \"ICES Scientists\": \"{5B2D929C-DA9B-45B8-8DAA-8150B2E76063}|{F8C8C01B-CFDC-4601-804E-F7C502970FCC}\",\r\n  \"Posted Date\": \"20221206T000000\",\r\n  \"Show on Publications Landing Page\": \"1\"\r\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2022\/December\/Association-of-topical-glaucoma-medications-with-lacrimal-drainage-obstruction"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Association of topical glaucoma medications with lacrimal drainage obstruction and eyelid malposition<\/title>\n<meta name=\"description\" content=\"Background\/objectives \u2014 Adverse effects of topical glaucoma medications (TGMs) may include development of ocular adnexal disorders. 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