{"id":1733,"date":"2022-12-06T00:00:00","date_gmt":"2022-12-06T05:00:00","guid":{"rendered":"https:\/\/icesontario.wpengine.com\/journal-articles\/population-study-of-sex-based-outcomes-after-surgical-aortic-valve-replacement\/"},"modified":"2023-07-19T13:15:53","modified_gmt":"2023-07-19T17:15:53","slug":"population-study-of-sex-based-outcomes-after-surgical-aortic-valve-replacement","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/population-study-of-sex-based-outcomes-after-surgical-aortic-valve-replacement\/","title":{"rendered":"Population study of sex-based outcomes after surgical aortic valve replacement"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 Surgical aortic valve replacement (SAVR) is a key strategy for the treatment of aortic valve disease. However, studies have primarily involved males and it\u2019s unclear as to whether these benefits can be extrapolated to females.<\/p>\n<p><strong>Methods<\/strong> \u2014 Clinical and administrative data sets for 12207 patients undergoing isolated SAVR in Ontario from 2008 \u2013 2019 were linked. Males and females were balanced using inverse probability treatment weighting. Mortality, endocarditis, and major hemorrhagic and thrombotic events, as well as two composite outcomes; MACCE (major adverse cerebral and cardiovascular events) and PACE (patient-derived adverse cardiovascular and noncardiovascular events) and their component events, were compared in the weighted groups with a stratified log rank test.<\/p>\n<p><strong>Results<\/strong> \u2014 There were 7485 males and 4722 females in the study. Median follow-up was 5.2 years in both sexes. There was no difference in all-cause mortality between sexes (HR 0.949 [95% CI 0.851-1.059]). Male sex was associated with an increased risk of new-onset dialysis (HR 0.689 [95% CI 0.488, 0.974]).<\/p>\n<p>Female sex was associated with a significantly increased risk of both new onset heart failure (HR 1.211 [95% CI 1.051-1.394] p=0.0081) and heart failure hospitalization (HR 1.200 [95% CI 1.036-1.390] p=0.015). There were no statistically significant differences in any of the other secondary outcomes between sexes.<\/p>\n<p><strong>Conclusions<\/strong> \u2014 This population health study demonstrated that there was no difference in survival between males and females undergoing SAVR. There were significant sex-related differences in the risk of heart failure and new-onset dialysis however these findings should be considered exploratory and require further study.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 Surgical aortic valve replacement (SAVR) is a key strategy for the treatment of aortic valve disease. However, studies have primarily involved males and it\u2019s unclear as to whether these benefits can be extrapolated to females. Methods \u2014 Clinical and administrative data sets for 12207 patients undergoing isolated SAVR in Ontario from 2008 \u2013 [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[40,25],"migration-helper-qa-sample-set":[],"class_list":["post-1733","journal_article","type-journal_article","status-publish","hentry","topic-cardiovascular-disease","topic-surgery"],"acf":{"citation":"Rubens FD, Clarke AE, Lee DS, Wells GA, Sun LY. <em>CJC Open<\/em>. 2022; Dec 6 [Epub ahead of print].","source_url":"https:\/\/www.cjcopen.ca\/article\/S2589-790X(22)00287-6\/fulltext","ices_scientist":[1350,1290],"site":[6734],"research_program":[6741],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"E4504552-E87A-49BA-BB03-70C4208B3D75","sitecore_item_name":"Population-study-of-sex-based-outcomes-after-surgical-aortic-valve-replacement","sitecore_field_values":"{\r\n  \"Title\": \"Population study of sex-based outcomes after surgical aortic valve replacement\",\r\n  \"Short title\": \"Population study of sex-based outcomes\",\r\n  \"Summary\": \"This population health study demonstrated that there was no difference in survival between males and females undergoing surgical aortic valve replacement.\",\r\n  \"Citation\": \"<p>Rubens FD, Clarke AE, Lee DS, Wells GA, Sun LY. <em>CJC Open<\/em>. 2022; Dec 6 [Epub ahead of print]. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.cjco.2022.12.001\" title=\"opens external link\">https:\/\/doi.org\/10.1016\/j.cjco.2022.12.001<\/a><\/p>\",\r\n  \"Abstract\": \"<p><strong>Background<\/strong> &mdash; Surgical aortic valve replacement (SAVR) is a key strategy for the treatment of aortic valve disease. However, studies have primarily involved males and it&rsquo;s unclear as to whether these benefits can be extrapolated to females.<\/p>n<p><strong>Methods<\/strong> &mdash; Clinical and administrative data sets for 12207 patients undergoing isolated SAVR in Ontario from 2008 &ndash; 2019 were linked. Males and females were balanced using inverse probability treatment weighting. Mortality, endocarditis, and major hemorrhagic and thrombotic events, as well as two composite outcomes; MACCE (major adverse cerebral and cardiovascular events) and PACE (patient-derived adverse cardiovascular and noncardiovascular events) and their component events, were compared in the weighted groups with a stratified log rank test.<\/p>n<p><strong>Results<\/strong> &mdash; There were 7485 males and 4722 females in the study. Median follow-up was 5.2 years in both sexes. There was no difference in all-cause mortality between sexes (HR 0.949 [95% CI 0.851-1.059]). Male sex was associated with an increased risk of new-onset dialysis (HR 0.689 [95% CI 0.488, 0.974]).<\/p>n<p>Female sex was associated with a significantly increased risk of both new onset heart failure (HR 1.211 [95% CI 1.051-1.394] p=0.0081) and heart failure hospitalization (HR 1.200 [95% CI 1.036-1.390] p=0.015). There were no statistically significant differences in any of the other secondary outcomes between sexes.<\/p>n<p><strong>Conclusions<\/strong> &mdash; This population health study demonstrated that there was no difference in survival between males and females undergoing SAVR. There were significant sex-related differences in the risk of heart failure and new-onset dialysis however these findings should be considered exploratory and require further study.<\/p>n<p><a href=\"https:\/\/www.cjcopen.ca\/article\/S2589-790X(22)00287-6\/fulltext\" title=\"opens external link\">View full&nbsp; text<\/a><\/p>\",\r\n  \"ICES Scientists\": \"{A8AB3D1C-BAB5-4AD8-90EF-12C9E0E07A9A}|{CEEE13AD-C7DE-455F-ACF8-AAD7D27BB178}\",\r\n  \"Posted Date\": \"20221206T000000\",\r\n  \"Show on Publications Landing Page\": \"1\"\r\n}","previous_url":"https:\/\/www.ices.on.ca\/Publications\/Journal-Articles\/2022\/December\/Population-study-of-sex-based-outcomes-after-surgical-aortic-valve-replacement"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Population study of sex-based outcomes after surgical aortic valve replacement<\/title>\n<meta name=\"description\" content=\"Background \u2014 Surgical aortic valve replacement (SAVR) is a key strategy for the treatment of aortic valve disease. 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