{"id":17108,"date":"2023-12-13T15:58:21","date_gmt":"2023-12-13T20:58:21","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&p=17108"},"modified":"2023-12-15T16:03:47","modified_gmt":"2023-12-15T21:03:47","slug":"early-versus-late-onset-interstitial-lung-disease","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/early-versus-late-onset-interstitial-lung-disease\/","title":{"rendered":"Early versus late onset interstitial lung disease in rheumatoid arthritis: an observational study of risk factors and mortality in Ontario, Canada"},"content":{"rendered":"

Background and Objective<\/strong> \u2014 Interstitial lung disease (ILD) can occur as a manifestation of rheumatoid arthritis (RA) at various times in the disease course. We aimed to identify factors associated with early versus late onset RA-ILD and how the timing of RA-ILD influenced surgical lung biopsy completion and mortality.<\/p>\n

Methods<\/strong> \u2014 We performed a retrospective observational study using health services data from Ontario, Canada. We identified RA cases between 2000 and 2020 using the Ontario Rheumatoid Arthritis Database. RA-ILD diagnosis required repeat physician visits for ILD, with early RA-ILD defined as within 1\u2009year of RA diagnosis. We performed multivariable logistic regression to identify factors associated with early RA-ILD and surgical lung biopsy completion, and multivariable cox-proportional hazards regression to evaluate the association of early versus late RA-ILD on all-cause and RA-ILD related mortality.<\/p>\n

Results<\/strong> \u2014 In total, we identified 3717 cases of RA-ILD. Older age at RA diagnosis [OR 1.04 (95%CI 1.03\u20131.05), p<\/em>\u2009<\u20090.0001], female sex [OR 1.16 (95%CI 1.01\u20131.35), p<\/em>\u2009=\u20090.04] and immigrating to Ontario [OR 1.70 (95%CI 1.35\u20132.14), p<\/em>\u2009<\u20090.0001] was associated with early RA-ILD. Patients with early versus late RA-ILD experienced similar odds of undergoing a surgical lung biopsy [OR 1.34 (95%CI 0.83\u20132.16), p<\/em>\u2009=\u20090.23]. Early RA-ILD was associated with increased all-cause mortality [HR 1.17 (95%CI 1.07\u20131.29), p<\/em>\u2009=\u20090.0009], primarily driven by an increase in RA-ILD related mortality [HR 1.45 (95%CI 1.19\u20131.76), p<\/em>\u2009=\u20090.0003].<\/p>\n

Conclusion<\/strong> \u2014 Age at RA onset, female sex and immigration status are associated with early RA-ILD. Patients with early RA-ILD experience increased all-cause and RA-ILD related mortality after adjusting for demographics and comorbidities.<\/p>\n","protected":false},"excerpt":{"rendered":"

Background and Objective \u2014 Interstitial lung disease (ILD) can occur as a manifestation of rheumatoid arthritis (RA) at various times in the disease course. We aimed to identify factors associated with early versus late onset RA-ILD and how the timing of RA-ILD influenced surgical lung biopsy completion and mortality. Methods \u2014 We performed a retrospective […]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[52],"migration-helper-qa-sample-set":[],"class_list":["post-17108","journal_article","type-journal_article","status-publish","hentry","topic-lung-health"],"acf":{"citation":"Fidler L, Widdifield J, Fisher J, Shapera S. Respirology<\/em>. 2023; Dec 13 [Epub ahead of print].","source_url":"https:\/\/doi.org\/10.1111\/resp.14645","ices_scientist":[1122,20911],"site":[6735],"research_program":[6746],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"\nICES | Early versus late onset interstitial lung disease in rheumatoid arthritis: an observational study of risk factors and mortality in Ontario, Canada<\/title>\n<meta name=\"description\" content=\"Background and Objective \u2014 Interstitial lung disease (ILD) can occur as a manifestation of rheumatoid arthritis (RA) at various times in the disease\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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