{"id":16853,"date":"2023-10-10T11:13:56","date_gmt":"2023-10-10T15:13:56","guid":{"rendered":"https:\/\/www.ices.on.ca\/?post_type=journal_article&#038;p=16853"},"modified":"2023-10-17T11:25:14","modified_gmt":"2023-10-17T15:25:14","slug":"trends-in-infection-related-and-infection-unrelated-cancer-incidence","status":"publish","type":"journal_article","link":"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/trends-in-infection-related-and-infection-unrelated-cancer-incidence\/","title":{"rendered":"Trends in infection-related and infection-unrelated cancer incidence among people with and without HIV infection in Ontario, Canada, 1996-2020: a population-based matched cohort study using health administrative data"},"content":{"rendered":"<p><strong>Background<\/strong> \u2014 People with HIV infection are at higher risk for certain cancers than the general population. We compared trends in infection-related and infection-unrelated cancers among people with and without HIV infection.<\/p>\n<p><strong>Methods<\/strong> \u2014 We conducted a retrospective population-based matched cohort study of adults with and without HIV infection using linked health administrative databases in Ontario, Canada. Participants were matched on birth year, sex, census division (rurality), neighbourhood income quintile and region of birth. We followed participants from cohort entry until the earliest of date of cancer diagnosis, date of death, Nov. 1, 2020, or date of loss to follow-up. Incident cancers identified from Jan. 1, 1996, to Nov. 1, 2020, were categorized as infection-related or-unrelated. We examined calendar periods 1996\u20132003, 2004\u20132011 and 2012\u20132020, corresponding to the early combination antiretroviral therapy (cART), established cART and contemporary cART eras, respectively. We used competing risk analyses to examine trends in cumulative incidence by calendar period, age and sex, and cause-specific hazard ratios (HRs).<\/p>\n<p><strong>Results<\/strong> \u2014 We matched 20 304 people with HIV infection to 20 304 people without HIV infection. A total of 2437 cancers were diagnosed, 1534 (62.9%) among infected people and 903 (37.0%) among uninfected people. The risk of infection-related cancer by age 65 years for people with HIV infection decreased from 19.0% (95% confidence interval [CI] 15.6%\u201322.3%) in 1996\u20132011 to 10.0% (95% CI 7.9%\u201312.1%) in 2012\u20132020. Compared to uninfected people, those with HIV infection had similar HRs of infection-unrelated cancer but increased rates of infection-related cancer, particularly among younger age groups (25.1 [95% CI 13.2\u201347.4] v. 1.9 [95% CI 1.0\u20133.7] for age 18\u201339 yr v. \u2265 70 yr); these trends were consistent when examined by sex.<\/p>\n<p><strong>Interpretation<\/strong> \u2014 We observed significantly higher rates of infection-related, but not infection-unrelated, cancer among people with HIV infection than among uninfected people. The elevated rate of infection-related cancer in 2012\u20132020 highlights the importance of early and sustained antiretroviral therapy along with cancer screening and prevention measures.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background \u2014 People with HIV infection are at higher risk for certain cancers than the general population. We compared trends in infection-related and infection-unrelated cancers among people with and without HIV infection. Methods \u2014 We conducted a retrospective population-based matched cohort study of adults with and without HIV infection using linked health administrative databases in [&hellip;]<\/p>\n","protected":false},"template":"","migration-helper-automated":[],"migration-manual":[],"topic":[38,42,39],"migration-helper-qa-sample-set":[],"class_list":["post-16853","journal_article","type-journal_article","status-publish","hentry","topic-cancer-and-cancer-screening","topic-chronic-diseases-and-multimorbidity","topic-infectious-diseases"],"acf":{"citation":"Nicolau IA, Moineddin R, Antoniou T, Brooks JD, Gillis JL, Kendall CE, Cooper C, Cotterchio M, Salters K, Smieja M, Kroch AE, Lindsay JD, Price C, Mohamed A, Burchell AN. <em>CMAJ Open<\/em>. 2023; 11(5):E894-905. Epub 2023 Oct 10.","source_url":"https:\/\/doi.org\/10.9778\/cmajo.20220230","ices_scientist":[1327,1171,1386,1157],"site":[6733],"research_program":[6747],"news_release":"","journal_article":"","atlas":"","research_report":"","infographic":"","video":"","downloads":null,"links":null,"sitecore_item_id":"","sitecore_item_name":"","sitecore_field_values":"","previous_url":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ICES | Trends in infection-related and infection-unrelated cancer incidence among people with and without HIV infection in Ontario, Canada, 1996-2020: a population-based matched cohort study using health administrative data<\/title>\n<meta name=\"description\" content=\"Background \u2014 People with HIV infection are at higher risk for certain cancers than the general population. We compared trends in infection-related and\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/trends-in-infection-related-and-infection-unrelated-cancer-incidence\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ICES | Trends in infection-related and infection-unrelated cancer incidence among people with and without HIV infection in Ontario, Canada, 1996-2020: a population-based matched cohort study using health administrative data\" \/>\n<meta property=\"og:description\" content=\"Background \u2014 People with HIV infection are at higher risk for certain cancers than the general population. We compared trends in infection-related and\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ices.on.ca\/fr\/publications\/journal-articles\/trends-in-infection-related-and-infection-unrelated-cancer-incidence\/\" \/>\n<meta property=\"og:site_name\" content=\"ICES\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ICESOntario\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-10-17T15:25:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ices.on.ca\/wp-content\/uploads\/2024\/11\/ic-es-data-discovery-better-health-logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/trends-in-infection-related-and-infection-unrelated-cancer-incidence\\\/\",\"url\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/publications\\\/journal-articles\\\/trends-in-infection-related-and-infection-unrelated-cancer-incidence\\\/\",\"name\":\"ICES | Trends in infection-related and infection-unrelated cancer incidence among people with and without HIV infection in Ontario, Canada, 1996-2020: a population-based matched cohort study using health administrative data\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ices.on.ca\\\/fr\\\/#website\"},\"datePublished\":\"2023-10-10T15:13:56+00:00\",\"dateModified\":\"2023-10-17T15:25:14+00:00\",\"description\":\"Background \u2014 People with HIV infection are at higher risk for certain cancers than the general population. 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